Human Pancreatic Lipase:  An Exposed Hydrophobic Loop from the C-terminal Domain May Contribute to Interfacial Binding

Epitope mapping was performed using four anti-HPL monoclonal antibodies (mAb's 81−23, 146−40, 315−25, and 320−24) directed against human pancreatic lipase (HPL). Three HPL mutants produced in insect cells were tested for this purpose: (i) N−HPL, which consists of only the N-terminal domain of H...

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