Disassembly of the Cholinergic Postsynaptic Apparatus Induced by Axotomy in Mouse Sympathetic Neurons: The Loss of Dystrophin and (β -dystroglycan Immunoreactivity Precedes that of the Acetylcholine Receptor

In mouse sympathetic superior cervical ganglion (SCG), cortical cytoskeletal proteins such as dystrophin (Dys) and β1Σ2 spectrin colocalize with β-dystroglycan (β-DG), a transmembrane dystrophin-associated protein, and the acetylcholine receptor (AChR) at the postsynaptic specialization. The functio...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 1998-08, Vol.57 (8), p.768-779
Hauptverfasser:	Zaccaria, M Letizia, De Stefano, M Egle, Properzi, Francesca, Gotti, Cecilia, Petrucci, Tamara C, Paggi, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - physiology Amino Acid Sequence Animals Autonomic Fibers, Postganglionic - physiology Axotomy Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Cytoskeletal Proteins - analysis Dystroglycans Dystrophin - analysis Immunohistochemistry Medical sciences Membrane Glycoproteins - analysis Mice Mice, Inbred C57BL Molecular Sequence Data Nerve Crush Nerve Tissue Proteins - analysis Nervous system (semeiology, syndromes) Neurology Neurons - physiology Superior Cervical Ganglion - cytology Superior Cervical Ganglion - physiology Synapses - physiology
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