Comparison of β-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients : amorphic plaques and cytoskeletal changes occur independently

Alzheimer's disease is characterized neuropathologically by senile plaques and cytoskeletal changes. It has been proposed that amorphic plaques would locally induce anterograde propagation of cytoskeletal changes in consecutive neurons followed by amorphic plaque deposition at their axonal term...

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Veröffentlicht in:Acta neuropathologica 1998-08, Vol.96 (2), p.129-138
Hauptverfasser: VAN DE NES, J. A. P, KAMPHORST, W, RAVID, R, SWAAB, D. F
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KAMPHORST, W
RAVID, R
SWAAB, D. F
description Alzheimer's disease is characterized neuropathologically by senile plaques and cytoskeletal changes. It has been proposed that amorphic plaques would locally induce anterograde propagation of cytoskeletal changes in consecutive neurons followed by amorphic plaque deposition at their axonal terminals. The Alzheimer changes would spread in this way along neural pathways. To test the 'primary amyloid anatomical cascade hypothesis', Congo red staining, beta-protein/A4 (Abeta) antiserum and Alz-50, which recognizes cytoskeletal changes, were applied to the hypothalamus and adjoining brain areas of five Alzheimer's disease patients of 40-90 years of age and five age- and sex-matched controls. The results showed that (1) virtually all Abeta plaques in the hypothalamus were of the Congo red-negative amorphic type; (2) amorphic plaques and Alz-50-stained cytokeletal changes were observed not only in all Alzheimer's disease patients but also in a non-demented, 90-year-old control subject; (3) the density of amorphic plaques in the hypothalamus was unrelated to the duration of the dementia; (4) the density of amorphic plaques was unrelated to that of Alz-50-stained cytoskeletal changes; (5) double-labeling with anti-Abeta and Alz-50 did not show an evident topical relationship between amorphic plaque deposition and the occurrence of cytoskeletal changes; and (6) the distribution of Abeta and Alz-50 staining in five brain areas, for which essential anatomical information is available, did not support the primary amyloid anatomical cascade hypothesis. Amorphic plaques and cytoskeletal changes rather occur independently.
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A. P</au><au>KAMPHORST, W</au><au>RAVID, R</au><au>SWAAB, D. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of β-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients : amorphic plaques and cytoskeletal changes occur independently</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>96</volume><issue>2</issue><spage>129</spage><epage>138</epage><pages>129-138</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>Alzheimer's disease is characterized neuropathologically by senile plaques and cytoskeletal changes. It has been proposed that amorphic plaques would locally induce anterograde propagation of cytoskeletal changes in consecutive neurons followed by amorphic plaque deposition at their axonal terminals. 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subjects Adult
Aged
Aged, 80 and over
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid
Amyloid beta-Peptides - metabolism
Antigens - metabolism
Biological and medical sciences
Brain
Coloring Agents
Cytoskeleton
Cytoskeleton - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia disorders
Female
Humans
Hypothalamus
Hypothalamus - metabolism
Hypothalamus - pathology
Hypotheses
Male
Medical sciences
Middle Aged
Nerve Tissue Proteins - metabolism
Neurodegenerative diseases
Neurology
Plaque, Amyloid - pathology
Senile plaques
title Comparison of β-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients : amorphic plaques and cytoskeletal changes occur independently
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