Induction of Bone Morphogenetic Protein-2 by Interleukin-1 in Human Fibroblasts

Rheumatoid arthritis and periodontitis are chronic inflammatory diseases associated with tissue destruction that is mediated in part by elevated levels of cytokines (e.g., interleukin-1 and tumor necrosis factor). Differential screening of a human synovial fibroblast cDNA library for interleukin-1 i...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-07, Vol.248 (3), p.450-453
Hauptverfasser:	Fowler, Martin J., Neff, Michael S., Borghaei, Ruth C., Pease, Elizabeth A., Mochan, Eugene, Thornton, Ruth D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - biosynthesis Cells, Cultured Culture Media, Conditioned Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation - drug effects Gene Library Gingiva - metabolism Humans Interleukin-1 - pharmacology Osteoarthritis - metabolism Protein Biosynthesis - drug effects RNA, Messenger - biosynthesis Synovial Membrane - metabolism Transcription, Genetic - drug effects Transforming Growth Factor beta
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