Camptothecins Inhibit the Utilization of Hydrogen Peroxide in the Ligation Step of Topoisomerase I Catalysis

The antitumor compounds camptothecin and its derivatives topotecan and irinotecan stabilize topoisomerase I cleavage complexes by inhibiting the religation reaction of the enzyme. Previous studies, using radiolabeled camptothecin or affinity labeling reagents structurally related to camptothecin, su...

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Veröffentlicht in:	Biochemistry (Easton) 1998-07, Vol.37 (30), p.10815-10827
Hauptverfasser:	Lisby, Michael, Krogh, Berit Olsen, Boege, Fritz, Westergaard, Ole, Knudsen, Birgitta Ruth
Format:	Artikel
Sprache:	eng
Schlagworte:	Camptothecin - pharmacology Catalysis - drug effects DNA - drug effects DNA - metabolism DNA Topoisomerases, Type I - metabolism Humans Hydrogen Peroxide - metabolism Hydrogen-Ion Concentration Hydrolysis - drug effects Models, Chemical Phenols - metabolism Substrate Specificity Superoxides - metabolism Topoisomerase I Inhibitors
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