New Substituted 1,4-Benzoxazine Derivatives with Potential Intracellular Calcium Activity

Substituted 1,4-benzoxazines bearing an amino side chain at the 2-position were prepared and were found to have a moderate activity on intracellular calcium. Of the compounds studied it was found that those which possess a homoveratrylamino moiety exhibited superior potency. The chain length and the...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-08, Vol.41 (17), p.3142-3158
Hauptverfasser:	Bourlot, Anne-Sophie, Sánchez, Isabel, Dureng, Georges, Guillaumet, Gérald, Massingham, Roy, Monteil, André, Winslow, Eileen, Pujol, M. Dolors, Mérour, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Benzoxazine Animals Aorta - drug effects Aorta - physiology Biological and medical sciences Calcium - metabolism Calcium Channel Blockers - chemical synthesis Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacology Cardiovascular system Drug Design In Vitro Techniques Male Medical sciences Miscellaneous Molecular Structure Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Oxazines - chemical synthesis Oxazines - chemistry Oxazines - pharmacology Pharmacology. Drug treatments Phenylephrine - pharmacology Rabbits Renal Artery - drug effects Renal Artery - physiology Second Messenger Systems Structure-Activity Relationship Vasoconstriction - drug effects
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