Association of an X-chromosome dodecamer insertional variant allele with mental retardation

Mental retardation is a prominent feature of many neurodevelopmental syndromes. In an attempt to identify genetic components of these illnesses, we isolated and sequenced a large number of human genomic cosmid inserts containing large trinucleotide repeats. One of these cosmids, Cos-4, maps to the X...

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Veröffentlicht in:	Molecular psychiatry 1998-07, Vol.3 (4), p.303-309
Hauptverfasser:	Philibert, R A, King, B H, Winfield, S, Cook, E H, Lee, Y-H, Stubblefield, B, Damschroder-Williams, P, Dea, C, Palotie, A, Tengstrom, C, Martin, B M, Ginns, E I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alleles Amino Acid Sequence Animals Antidepressants Base Sequence Behavioral Sciences Biological and medical sciences Biological Psychology California - epidemiology Chromosome Mapping Conserved Sequence Cosmids DNA Transposable Elements Europe - epidemiology Exons Female Finland - epidemiology Fragile X syndrome Fragile X Syndrome - genetics Gene Library Gene mapping Gene polymorphism Genetic Variation Humans Hypothyroidism Hypothyroidism - epidemiology Hypothyroidism - genetics immediate-communication In Situ Hybridization, Fluorescence Intellectual deficiency Intellectual disabilities Intellectual Disability - genetics Male Males Medical sciences Medicine Medicine & Public Health Mice Molecular Sequence Data mRNA Multivariate analysis Neurosciences Pharmacotherapy Polymorphism Polymorphism, Genetic Prevalence Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sequence Alignment Sequence Homology, Amino Acid Trinucleotide Repeats X Chromosome X chromosomes
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