Helicobacter pylori Infection May Undergo Spontaneous Eradication in Children: A 2‐Year Follow‐Up Study
ABSTRACT Background: Helicobacter pylori infection is generally acquired early in life. However, it is still unknown whether a spontaneous eradication can occur. The purpose of this study was to evaluate whether H. pylori infection can undergo spontaneous eradication in children. Methods: Three hund...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1998-08, Vol.27 (2), p.181-183 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Perri, Francesco Pastore, Maria Clemente, Rocco Festa, Virginia Quitadamo, Michele Niro, Grazia Conoscitore, Pasquale Rutgeerts, Paul Andriulli, Angelo |
| description | ABSTRACT
Background:
Helicobacter pylori infection is generally acquired early in life. However, it is still unknown whether a spontaneous eradication can occur. The purpose of this study was to evaluate whether H. pylori infection can undergo spontaneous eradication in children.
Methods:
Three hundred and four Italian children (age range, 4.5 to 18.5 years) were tested for H. pylori by means of 13C‐urea breath test. Infected children were followed up every 6 months for as long as 2 years. Parents were instructed to record consumption of antibiotics. At each visit, children underwent a repeat 13C‐urea breath test.
Results:
Eighty‐five out of 304 (27.9%) children were H. pylori infected. Forty‐eight out of 85 infected children (56.4%) participated in the follow‐up study. After 2 years, 8 (16.6%) infected children had negative results on 13C‐urea breath tests; 2 of them were given antibiotics for concomitant infections. One child was negative at 6 months but became positive again at the next 6‐month 13C‐urea breath test. Forty children remained persistently positive; of them, 10 were treated with a short course of antibiotics.
Conclusions:
Our findings support the hypothesis that, at least during childhood,H. pylori infection may be a fluctuating disease with spontaneous eradication and possible recurrence. |
| doi_str_mv | 10.1002/j.1536-4801.1998.tb01131.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73836016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73836016</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2950-def182221b183910b7d079994a5970a412dd7d7422799dcaaf77f0e9fea2c9b23</originalsourceid><addsrcrecordid>eNqVUctu1DAUjRCoDIVPQLIQYpfg6zwcd9eOOrSoPKQyC1aWYzuMp5442BlNs-MT-Ea-BIeJZs_Csu4959x7dG6SvAGcAcbk_TaDMq_SosaQAWN1NjQYIIfs8UmyOEFPkwUmlKYEoHqevAhhizGmRYnPkjNGMalKvEgebrQ10jVCDtqjfrTOG3TbtVoOxnXokxjRulPa_3DovnfdIDrt9gFde6GMFP84pkPLjbHK6-4CXSLy59fv71p4tHLWukOs1j26H_ZqfJk8a4UN-tX8nyfr1fW35U169-XD7fLyLpWElThVuoWaEAIN1DkD3FCFKWOsEGW0LQogSlFFC0JiV0khWkpbrFmrBZGsIfl58u44t_fu516Hge9MkNrao3lO8zqvMFSReHEkSu9C8LrlvTc74UcOmE9J8y2f4uRTnHxKms9J88cofj1v2Tc7rU7SOdqIv51xEaSwrRedNOFEI3lZEDaZLY60g7PxBOHB7g_a840WdtjweDFcAq3SaTmuY5XGB9P05SwzVo__4Zt__Po5v1oBKQqa_wUbf61T</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73836016</pqid></control><display><type>article</type><title>Helicobacter pylori Infection May Undergo Spontaneous Eradication in Children: A 2‐Year Follow‐Up Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Perri, Francesco ; Pastore, Maria ; Clemente, Rocco ; Festa, Virginia ; Quitadamo, Michele ; Niro, Grazia ; Conoscitore, Pasquale ; Rutgeerts, Paul ; Andriulli, Angelo</creator><creatorcontrib>Perri, Francesco ; Pastore, Maria ; Clemente, Rocco ; Festa, Virginia ; Quitadamo, Michele ; Niro, Grazia ; Conoscitore, Pasquale ; Rutgeerts, Paul ; Andriulli, Angelo</creatorcontrib><description>ABSTRACT
Background:
Helicobacter pylori infection is generally acquired early in life. However, it is still unknown whether a spontaneous eradication can occur. The purpose of this study was to evaluate whether H. pylori infection can undergo spontaneous eradication in children.
Methods:
Three hundred and four Italian children (age range, 4.5 to 18.5 years) were tested for H. pylori by means of 13C‐urea breath test. Infected children were followed up every 6 months for as long as 2 years. Parents were instructed to record consumption of antibiotics. At each visit, children underwent a repeat 13C‐urea breath test.
Results:
Eighty‐five out of 304 (27.9%) children were H. pylori infected. Forty‐eight out of 85 infected children (56.4%) participated in the follow‐up study. After 2 years, 8 (16.6%) infected children had negative results on 13C‐urea breath tests; 2 of them were given antibiotics for concomitant infections. One child was negative at 6 months but became positive again at the next 6‐month 13C‐urea breath test. Forty children remained persistently positive; of them, 10 were treated with a short course of antibiotics.
Conclusions:
Our findings support the hypothesis that, at least during childhood,H. pylori infection may be a fluctuating disease with spontaneous eradication and possible recurrence.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1998.tb01131.x</identifier><identifier>PMID: 9702650</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adolescent ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Breath test ; Breath Tests ; Carbon Isotopes ; Child ; Child, Preschool ; Children ; Eradication ; Follow-Up Studies ; Gastritis ; Helicobacter Infections - diagnosis ; Helicobacter pylori ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Prospective Studies ; Recurrence ; Remission, Spontaneous ; Urea</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1998-08, Vol.27 (2), p.181-183</ispartof><rights>1998 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Lippincott-Raven Publishers</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2950-def182221b183910b7d079994a5970a412dd7d7422799dcaaf77f0e9fea2c9b23</citedby><cites>FETCH-LOGICAL-c2950-def182221b183910b7d079994a5970a412dd7d7422799dcaaf77f0e9fea2c9b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1536-4801.1998.tb01131.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,23910,23911,25119,27903,27904,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2354292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9702650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perri, Francesco</creatorcontrib><creatorcontrib>Pastore, Maria</creatorcontrib><creatorcontrib>Clemente, Rocco</creatorcontrib><creatorcontrib>Festa, Virginia</creatorcontrib><creatorcontrib>Quitadamo, Michele</creatorcontrib><creatorcontrib>Niro, Grazia</creatorcontrib><creatorcontrib>Conoscitore, Pasquale</creatorcontrib><creatorcontrib>Rutgeerts, Paul</creatorcontrib><creatorcontrib>Andriulli, Angelo</creatorcontrib><title>Helicobacter pylori Infection May Undergo Spontaneous Eradication in Children: A 2‐Year Follow‐Up Study</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Background:
Helicobacter pylori infection is generally acquired early in life. However, it is still unknown whether a spontaneous eradication can occur. The purpose of this study was to evaluate whether H. pylori infection can undergo spontaneous eradication in children.
Methods:
Three hundred and four Italian children (age range, 4.5 to 18.5 years) were tested for H. pylori by means of 13C‐urea breath test. Infected children were followed up every 6 months for as long as 2 years. Parents were instructed to record consumption of antibiotics. At each visit, children underwent a repeat 13C‐urea breath test.
Results:
Eighty‐five out of 304 (27.9%) children were H. pylori infected. Forty‐eight out of 85 infected children (56.4%) participated in the follow‐up study. After 2 years, 8 (16.6%) infected children had negative results on 13C‐urea breath tests; 2 of them were given antibiotics for concomitant infections. One child was negative at 6 months but became positive again at the next 6‐month 13C‐urea breath test. Forty children remained persistently positive; of them, 10 were treated with a short course of antibiotics.
Conclusions:
Our findings support the hypothesis that, at least during childhood,H. pylori infection may be a fluctuating disease with spontaneous eradication and possible recurrence.</description><subject>Adolescent</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Breath test</subject><subject>Breath Tests</subject><subject>Carbon Isotopes</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Eradication</subject><subject>Follow-Up Studies</subject><subject>Gastritis</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter pylori</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Remission, Spontaneous</subject><subject>Urea</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUctu1DAUjRCoDIVPQLIQYpfg6zwcd9eOOrSoPKQyC1aWYzuMp5442BlNs-MT-Ea-BIeJZs_Csu4959x7dG6SvAGcAcbk_TaDMq_SosaQAWN1NjQYIIfs8UmyOEFPkwUmlKYEoHqevAhhizGmRYnPkjNGMalKvEgebrQ10jVCDtqjfrTOG3TbtVoOxnXokxjRulPa_3DovnfdIDrt9gFde6GMFP84pkPLjbHK6-4CXSLy59fv71p4tHLWukOs1j26H_ZqfJk8a4UN-tX8nyfr1fW35U169-XD7fLyLpWElThVuoWaEAIN1DkD3FCFKWOsEGW0LQogSlFFC0JiV0khWkpbrFmrBZGsIfl58u44t_fu516Hge9MkNrao3lO8zqvMFSReHEkSu9C8LrlvTc74UcOmE9J8y2f4uRTnHxKms9J88cofj1v2Tc7rU7SOdqIv51xEaSwrRedNOFEI3lZEDaZLY60g7PxBOHB7g_a840WdtjweDFcAq3SaTmuY5XGB9P05SwzVo__4Zt__Po5v1oBKQqa_wUbf61T</recordid><startdate>199808</startdate><enddate>199808</enddate><creator>Perri, Francesco</creator><creator>Pastore, Maria</creator><creator>Clemente, Rocco</creator><creator>Festa, Virginia</creator><creator>Quitadamo, Michele</creator><creator>Niro, Grazia</creator><creator>Conoscitore, Pasquale</creator><creator>Rutgeerts, Paul</creator><creator>Andriulli, Angelo</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199808</creationdate><title>Helicobacter pylori Infection May Undergo Spontaneous Eradication in Children: A 2‐Year Follow‐Up Study</title><author>Perri, Francesco ; Pastore, Maria ; Clemente, Rocco ; Festa, Virginia ; Quitadamo, Michele ; Niro, Grazia ; Conoscitore, Pasquale ; Rutgeerts, Paul ; Andriulli, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2950-def182221b183910b7d079994a5970a412dd7d7422799dcaaf77f0e9fea2c9b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Breath test</topic><topic>Breath Tests</topic><topic>Carbon Isotopes</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Eradication</topic><topic>Follow-Up Studies</topic><topic>Gastritis</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter pylori</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Remission, Spontaneous</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perri, Francesco</creatorcontrib><creatorcontrib>Pastore, Maria</creatorcontrib><creatorcontrib>Clemente, Rocco</creatorcontrib><creatorcontrib>Festa, Virginia</creatorcontrib><creatorcontrib>Quitadamo, Michele</creatorcontrib><creatorcontrib>Niro, Grazia</creatorcontrib><creatorcontrib>Conoscitore, Pasquale</creatorcontrib><creatorcontrib>Rutgeerts, Paul</creatorcontrib><creatorcontrib>Andriulli, Angelo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perri, Francesco</au><au>Pastore, Maria</au><au>Clemente, Rocco</au><au>Festa, Virginia</au><au>Quitadamo, Michele</au><au>Niro, Grazia</au><au>Conoscitore, Pasquale</au><au>Rutgeerts, Paul</au><au>Andriulli, Angelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helicobacter pylori Infection May Undergo Spontaneous Eradication in Children: A 2‐Year Follow‐Up Study</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1998-08</date><risdate>1998</risdate><volume>27</volume><issue>2</issue><spage>181</spage><epage>183</epage><pages>181-183</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Background:
Helicobacter pylori infection is generally acquired early in life. However, it is still unknown whether a spontaneous eradication can occur. The purpose of this study was to evaluate whether H. pylori infection can undergo spontaneous eradication in children.
Methods:
Three hundred and four Italian children (age range, 4.5 to 18.5 years) were tested for H. pylori by means of 13C‐urea breath test. Infected children were followed up every 6 months for as long as 2 years. Parents were instructed to record consumption of antibiotics. At each visit, children underwent a repeat 13C‐urea breath test.
Results:
Eighty‐five out of 304 (27.9%) children were H. pylori infected. Forty‐eight out of 85 infected children (56.4%) participated in the follow‐up study. After 2 years, 8 (16.6%) infected children had negative results on 13C‐urea breath tests; 2 of them were given antibiotics for concomitant infections. One child was negative at 6 months but became positive again at the next 6‐month 13C‐urea breath test. Forty children remained persistently positive; of them, 10 were treated with a short course of antibiotics.
Conclusions:
Our findings support the hypothesis that, at least during childhood,H. pylori infection may be a fluctuating disease with spontaneous eradication and possible recurrence.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9702650</pmid><doi>10.1002/j.1536-4801.1998.tb01131.x</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 1998-08, Vol.27 (2), p.181-183 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Adolescent Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Breath test Breath Tests Carbon Isotopes Child Child, Preschool Children Eradication Follow-Up Studies Gastritis Helicobacter Infections - diagnosis Helicobacter pylori Human bacterial diseases Humans Infectious diseases Medical sciences Prospective Studies Recurrence Remission, Spontaneous Urea |
| title | Helicobacter pylori Infection May Undergo Spontaneous Eradication in Children: A 2‐Year Follow‐Up Study |
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