Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats
The purpose of the present study was to examine the importance of magnesium in endothelial function after arterial balloon injury. Male Wistar rats were fed normal, high or low concentrations of magnesium. Three weeks later the animals underwent endothelial injury of the thoracic aorta by a balloon...
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| Veröffentlicht in: | Atherosclerosis 1998-08, Vol.139 (2), p.237-242 |
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| container_title | Atherosclerosis |
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| creator | Fonseca, Francisco A.H Paiva, Therezinha B Silva, Eneida G Ihara, Silvia S.M Kasinski, Nelson Martinez, Tânia L.R Filho, Eulógio E.M |
| description | The purpose of the present study was to examine the importance of magnesium in endothelial function after arterial balloon injury. Male Wistar rats were fed normal, high or low concentrations of magnesium. Three weeks later the animals underwent endothelial injury of the thoracic aorta by a balloon catheter or a sham operation. Biochemical, histological and endothelial function analysis were performed 15 days after the surgical treatment. The animals fed a low magnesium diet presented the lowest level of serum magnesium and the highest ionized blood calcium levels. Histomorphometric analysis revealed no differences among groups neither regarding the magnitude of intimal thickening nor the recovery of endothelial coverage. However, when vasoreactivity responses were compared in the balloon-injured group, those animals fed a high magnesium diet had the better endothelium-dependent vascular relaxation. In conclusion, a higher magnesium level in the diet was beneficial to vessels that underwent endothelial injury by balloon catheter. |
| doi_str_mv | 10.1016/S0021-9150(98)00069-0 |
| format | Article |
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Male Wistar rats were fed normal, high or low concentrations of magnesium. Three weeks later the animals underwent endothelial injury of the thoracic aorta by a balloon catheter or a sham operation. Biochemical, histological and endothelial function analysis were performed 15 days after the surgical treatment. The animals fed a low magnesium diet presented the lowest level of serum magnesium and the highest ionized blood calcium levels. Histomorphometric analysis revealed no differences among groups neither regarding the magnitude of intimal thickening nor the recovery of endothelial coverage. However, when vasoreactivity responses were compared in the balloon-injured group, those animals fed a high magnesium diet had the better endothelium-dependent vascular relaxation. In conclusion, a higher magnesium level in the diet was beneficial to vessels that underwent endothelial injury by balloon catheter.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(98)00069-0</identifier><identifier>PMID: 9712329</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Animals ; Aorta, Thoracic - injuries ; Aorta, Thoracic - pathology ; Aorta, Thoracic - physiopathology ; Balloon-injury ; Biological and medical sciences ; Calcium - blood ; Catheterization - adverse effects ; Diet ; Diseases of the cardiovascular system ; Endothelium ; Endothelium, Vascular - physiopathology ; Endothelium-derived relaxing factor ; Magnesium ; Magnesium - administration & dosage ; Magnesium - blood ; Magnesium - pharmacology ; Male ; Medical sciences ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Rats ; Rats, Wistar ; Vasodilation - drug effects ; Wounds, Nonpenetrating - blood ; Wounds, Nonpenetrating - pathology ; Wounds, Nonpenetrating - physiopathology</subject><ispartof>Atherosclerosis, 1998-08, Vol.139 (2), p.237-242</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b556c393568d56c5669b7868a0dc587ac26f9aa5ab3209e36a7e4a7a52c3879e3</citedby><cites>FETCH-LOGICAL-c389t-b556c393568d56c5669b7868a0dc587ac26f9aa5ab3209e36a7e4a7a52c3879e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915098000690$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2333633$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9712329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fonseca, Francisco A.H</creatorcontrib><creatorcontrib>Paiva, Therezinha B</creatorcontrib><creatorcontrib>Silva, Eneida G</creatorcontrib><creatorcontrib>Ihara, Silvia S.M</creatorcontrib><creatorcontrib>Kasinski, Nelson</creatorcontrib><creatorcontrib>Martinez, Tânia L.R</creatorcontrib><creatorcontrib>Filho, Eulógio E.M</creatorcontrib><title>Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>The purpose of the present study was to examine the importance of magnesium in endothelial function after arterial balloon injury. Male Wistar rats were fed normal, high or low concentrations of magnesium. Three weeks later the animals underwent endothelial injury of the thoracic aorta by a balloon catheter or a sham operation. Biochemical, histological and endothelial function analysis were performed 15 days after the surgical treatment. The animals fed a low magnesium diet presented the lowest level of serum magnesium and the highest ionized blood calcium levels. Histomorphometric analysis revealed no differences among groups neither regarding the magnitude of intimal thickening nor the recovery of endothelial coverage. However, when vasoreactivity responses were compared in the balloon-injured group, those animals fed a high magnesium diet had the better endothelium-dependent vascular relaxation. In conclusion, a higher magnesium level in the diet was beneficial to vessels that underwent endothelial injury by balloon catheter.</description><subject>Animals</subject><subject>Aorta, Thoracic - injuries</subject><subject>Aorta, Thoracic - pathology</subject><subject>Aorta, Thoracic - physiopathology</subject><subject>Balloon-injury</subject><subject>Biological and medical sciences</subject><subject>Calcium - blood</subject><subject>Catheterization - adverse effects</subject><subject>Diet</subject><subject>Diseases of the cardiovascular system</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Endothelium-derived relaxing factor</subject><subject>Magnesium</subject><subject>Magnesium - administration & dosage</subject><subject>Magnesium - blood</subject><subject>Magnesium - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vasodilation - drug effects</subject><subject>Wounds, Nonpenetrating - blood</subject><subject>Wounds, Nonpenetrating - pathology</subject><subject>Wounds, Nonpenetrating - physiopathology</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2PFCEQhonRrOPoT9iEgzF6aIWm-ToZs34mm3hQz6SarlY2ND0CvdF_L7szmasHQkE9L1QeQi45e80ZV2--MdbzznLJXlrzijGmbMcekB032nZ8MMNDsjsjj8mTUm4aNGhuLsiF1bwXvd0R9z5ghfyXLvAzYQnbQsNyyOstFoppWusvjAEinfDQjpgqzRjhD9SwJrrOdIQY11aGdLNlnCjkijm0cEg0Qy1PyaMZYsFnp31Pfnz88P3qc3f99dOXq3fXnRfG1m6UUnlhhVRmapVUyo7aKANs8tJo8L2aLYCEUfTMolCgcQANsm953S725MXx3Tb77w1LdUsoHmOEhOtWnBZGSDHoBsoj6PNaSsbZHXJYmgHHmbsT6-7Fujtrzhp3L9axlrs8fbCNC07n1Mlk6z8_9aF4iHOG5EM5Y70QQrW1J2-PGDYZtwGzKz5g8jiFjL66aQ3_GeQfKtuVwA</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Fonseca, Francisco A.H</creator><creator>Paiva, Therezinha B</creator><creator>Silva, Eneida G</creator><creator>Ihara, Silvia S.M</creator><creator>Kasinski, Nelson</creator><creator>Martinez, Tânia L.R</creator><creator>Filho, Eulógio E.M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats</title><author>Fonseca, Francisco A.H ; Paiva, Therezinha B ; Silva, Eneida G ; Ihara, Silvia S.M ; Kasinski, Nelson ; Martinez, Tânia L.R ; Filho, Eulógio E.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-b556c393568d56c5669b7868a0dc587ac26f9aa5ab3209e36a7e4a7a52c3879e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Aorta, Thoracic - injuries</topic><topic>Aorta, Thoracic - pathology</topic><topic>Aorta, Thoracic - physiopathology</topic><topic>Balloon-injury</topic><topic>Biological and medical sciences</topic><topic>Calcium - blood</topic><topic>Catheterization - adverse effects</topic><topic>Diet</topic><topic>Diseases of the cardiovascular system</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Endothelium-derived relaxing factor</topic><topic>Magnesium</topic><topic>Magnesium - administration & dosage</topic><topic>Magnesium - blood</topic><topic>Magnesium - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Radiotherapy. 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Male Wistar rats were fed normal, high or low concentrations of magnesium. Three weeks later the animals underwent endothelial injury of the thoracic aorta by a balloon catheter or a sham operation. Biochemical, histological and endothelial function analysis were performed 15 days after the surgical treatment. The animals fed a low magnesium diet presented the lowest level of serum magnesium and the highest ionized blood calcium levels. Histomorphometric analysis revealed no differences among groups neither regarding the magnitude of intimal thickening nor the recovery of endothelial coverage. However, when vasoreactivity responses were compared in the balloon-injured group, those animals fed a high magnesium diet had the better endothelium-dependent vascular relaxation. 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| subjects | Animals Aorta, Thoracic - injuries Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Balloon-injury Biological and medical sciences Calcium - blood Catheterization - adverse effects Diet Diseases of the cardiovascular system Endothelium Endothelium, Vascular - physiopathology Endothelium-derived relaxing factor Magnesium Magnesium - administration & dosage Magnesium - blood Magnesium - pharmacology Male Medical sciences Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Wistar Vasodilation - drug effects Wounds, Nonpenetrating - blood Wounds, Nonpenetrating - pathology Wounds, Nonpenetrating - physiopathology |
| title | Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats |
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