Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: Gender differences
Up‐regulation of brain nicotinic receptors (nAChRs) by chronic nicotine treatment has chiefly been demonstrated by in vitro binding assays. Here, we report that up‐regulation of nAChRs in CD‐1 mice can be detected using a specific in vivo radioligand for nAChRs, [125I]IPH. After 10 days of (−)‐nicot...
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| Veröffentlicht in: | Synapse (New York, N.Y.) N.Y.), 1998-09, Vol.30 (1), p.116-118 |
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| container_title | Synapse (New York, N.Y.) |
| container_volume | 30 |
| creator | Mochizuki, Takao Villemagne, Victor L. Scheffel, Ursula Dannals, Robert F. Finley, Paige Zhan, Yougen Wagner, Henry N. Musachio, John L. |
| description | Up‐regulation of brain nicotinic receptors (nAChRs) by chronic nicotine treatment has chiefly been demonstrated by in vitro binding assays. Here, we report that up‐regulation of nAChRs in CD‐1 mice can be detected using a specific in vivo radioligand for nAChRs, [125I]IPH. After 10 days of (−)‐nicotine administration, male and female mice demonstrated a significant elevation of [125I]IPH binding in all brain regions studied. [125I]lPH uptake also displayed significant gender differences with male animals showing a more pronounced increase in [125I]IPH accumulation. Synapse 29: 116–118, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1098-2396(199809)30:1<116::AID-SYN15>3.0.CO;2-2 |
| format | Article |
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Here, we report that up‐regulation of nAChRs in CD‐1 mice can be detected using a specific in vivo radioligand for nAChRs, [125I]IPH. After 10 days of (−)‐nicotine administration, male and female mice demonstrated a significant elevation of [125I]IPH binding in all brain regions studied. [125I]lPH uptake also displayed significant gender differences with male animals showing a more pronounced increase in [125I]IPH accumulation. Synapse 29: 116–118, 1998. © 1998 Wiley‐Liss, Inc.</description><identifier>ISSN: 0887-4476</identifier><identifier>EISSN: 1098-2396</identifier><identifier>DOI: 10.1002/(SICI)1098-2396(199809)30:1<116::AID-SYN15>3.0.CO;2-2</identifier><identifier>PMID: 9704889</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; brain ; Brain - drug effects ; Brain - metabolism ; Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics ; Female ; gender ; Iodine Radioisotopes ; Male ; Mice ; nicotine ; Nicotine - pharmacology ; Nicotinic Agonists - pharmacokinetics ; Pyridines - pharmacokinetics ; Radioligand Assay ; radiotracer ; Receptors, Nicotinic - biosynthesis ; Sex Characteristics ; Up-Regulation - drug effects</subject><ispartof>Synapse (New York, N.Y.), 1998-09, Vol.30 (1), p.116-118</ispartof><rights>Copyright © 1998 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291098-2396%28199809%2930%3A1%3C116%3A%3AAID-SYN15%3E3.0.CO%3B2-2$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291098-2396%28199809%2930%3A1%3C116%3A%3AAID-SYN15%3E3.0.CO%3B2-2$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9704889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mochizuki, Takao</creatorcontrib><creatorcontrib>Villemagne, Victor L.</creatorcontrib><creatorcontrib>Scheffel, Ursula</creatorcontrib><creatorcontrib>Dannals, Robert F.</creatorcontrib><creatorcontrib>Finley, Paige</creatorcontrib><creatorcontrib>Zhan, Yougen</creatorcontrib><creatorcontrib>Wagner, Henry N.</creatorcontrib><creatorcontrib>Musachio, John L.</creatorcontrib><title>Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: Gender differences</title><title>Synapse (New York, N.Y.)</title><addtitle>Synapse</addtitle><description>Up‐regulation of brain nicotinic receptors (nAChRs) by chronic nicotine treatment has chiefly been demonstrated by in vitro binding assays. 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Synapse 29: 116–118, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics</subject><subject>Female</subject><subject>gender</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Mice</subject><subject>nicotine</subject><subject>Nicotine - pharmacology</subject><subject>Nicotinic Agonists - pharmacokinetics</subject><subject>Pyridines - pharmacokinetics</subject><subject>Radioligand Assay</subject><subject>radiotracer</subject><subject>Receptors, Nicotinic - biosynthesis</subject><subject>Sex Characteristics</subject><subject>Up-Regulation - drug effects</subject><issn>0887-4476</issn><issn>1098-2396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv00AUhS0EKqHwE5BmhdqFw7zsscNDqlwaIlWJRAMVqytnfAeGxnaYsVu64q8zxlE2IHU1j3PuOVf6ougdo1NGKX99crUoFqeM5lnMRZ6esDzPaH4q6Iy9ZSydzc4W5_HV1yVL3ospnRarNzzmj6LJYeJxNKFZpmIpVfo0eub9D0qpYFQeRUe5ojLL8kn0e2l129kGiW2qXmNF-l3s8Fu_LTvbNqQ1pBkdVhOHGndd63wwk-I8ZqS2GkmFddv4zpVdGL-z3XdSNoPj1t62xJWVbYOm0c3IHJsKHamsMeiw0eifR09MufX4Yn8eR58vPqyLj_Hlar4ozi5jLaRKYpQqS5OS8Sxc-EbosIlhGyVNYrhMOTWJlBtDua6MKhnjiNSI8KRUZ9UmF8fRqzF359qfPfoOaus1brdlg23vQYlMJFQlDxpZKnOeJlwcNtWu9d6hgZ2zdenugVEYCAIMBGHgAQMPGAmCCDIEggCBIPwlCAIoFCvgMOS-3C_Qb2qsDql7ZEH_Mup3dov3_5Q-0Pm_yvEjBMdjsPUd_joEl-4GUiVUAtfLOVysGbte00-QiD8h8sa2</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>Mochizuki, Takao</creator><creator>Villemagne, Victor L.</creator><creator>Scheffel, Ursula</creator><creator>Dannals, Robert F.</creator><creator>Finley, Paige</creator><creator>Zhan, Yougen</creator><creator>Wagner, Henry N.</creator><creator>Musachio, John L.</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: Gender differences</title><author>Mochizuki, Takao ; 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| ispartof | Synapse (New York, N.Y.), 1998-09, Vol.30 (1), p.116-118 |
| issn | 0887-4476 1098-2396 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals brain Brain - drug effects Brain - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics Female gender Iodine Radioisotopes Male Mice nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacokinetics Pyridines - pharmacokinetics Radioligand Assay radiotracer Receptors, Nicotinic - biosynthesis Sex Characteristics Up-Regulation - drug effects |
| title | Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: Gender differences |
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