Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings

Seven metabolites of valproic acid (VPA), i.e. 2-en-VPA, 3-en-VPA, 4-en-VPA, 3-hydroxy-VPA, 4-hydroxy-VPA, 5-hydroxy-VPA and 3-keto-VPA and valproic acid itself were examined for their effects on the metabolism of γ-aminobutyric acid (GABA) in the brain and brain nerve endings (synaptosomes) in mice...

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Veröffentlicht in:	Neuropharmacology 1981-12, Vol.20 (12), p.1187-1192
Hauptverfasser:	Löscher, W., Böhme, G., Schäfer, H., Kochen, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobutyrate Transaminase - metabolism Animals brain Brain - drug effects Brain - enzymology Brain - metabolism GABA gamma-Aminobutyric Acid - metabolism Glutamate Decarboxylase - metabolism Male metabolites Mice nerve endings Nerve Endings - drug effects Nerve Endings - metabolism Synaptosomes - metabolism valproic acid Valproic Acid - metabolism Valproic Acid - pharmacology
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