Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients

Melanocortins are proopiomelanocortin-derived peptides that include adrenocorticotropic hormone [ACTH (1–39)], α-melanocyte-stimulating hormone [α-MSH (1–13)], and related amino acid sequences. Melanocortin peptides have potent antiinflammatory/anticytokine activity. Because cytokines such as interl...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1998-01, Vol.19 (6), p.1099-1104
Hauptverfasser:	Catania, Anna, Garofalo, Letizia, Cutuli, Mariagrazia, Gringeri, Alessandro, Santagostino, Elena, Lipton, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic hormone Adrenocorticotropic Hormone - pharmacology Adult AIDS/HIV alpha-MSH - pharmacology Cosyntropin - pharmacology Female HIV Envelope Protein gp120 - pharmacology HIV Infections - blood Human immunodeficiency virus Humans In Vitro Techniques Interleukin 1 Interleukin-1 - blood Male Melanocortin peptides Monocytes - drug effects Monocytes - metabolism TNF α Tumor Necrosis Factor-alpha - metabolism α-melanocyte-stimulating hormone
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