Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients
Melanocortins are proopiomelanocortin-derived peptides that include adrenocorticotropic hormone [ACTH (1–39)], α-melanocyte-stimulating hormone [α-MSH (1–13)], and related amino acid sequences. Melanocortin peptides have potent antiinflammatory/anticytokine activity. Because cytokines such as interl...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1998-01, Vol.19 (6), p.1099-1104 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Catania, Anna Garofalo, Letizia Cutuli, Mariagrazia Gringeri, Alessandro Santagostino, Elena Lipton, James M. |
| description | Melanocortins are proopiomelanocortin-derived peptides that include adrenocorticotropic hormone [ACTH (1–39)], α-melanocyte-stimulating hormone [α-MSH (1–13)], and related amino acid sequences. Melanocortin peptides have potent antiinflammatory/anticytokine activity. Because cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF) can be detrimental in HIV-infected patients, we investigated the effects of melanocortins on production of IL-1 and TNF α in the blood of HIV patients. Cytokine production was measured in whole blood samples stimulated with LPS in the presence or absence of α-MSH (1–13), α-MSH (11–13), ACTH (1–24), or ACTH (1–39). Melanocortins reduced production of both cytokines in a concentration-dependent fashion. In separate experiments on normal peripheral blood mononuclear cells (PBMC), α-MSH (1–13) inhibited production of IL-1 β and TNF α induced by HIV envelope glycoprotein gp 120. These results suggest that stimulation of melanocortin receptors in inflammatory cells could be a novel way to reduce production of cytokines that promote HIV replication. |
| doi_str_mv | 10.1016/S0196-9781(98)00055-2 |
| format | Article |
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Melanocortin peptides have potent antiinflammatory/anticytokine activity. Because cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF) can be detrimental in HIV-infected patients, we investigated the effects of melanocortins on production of IL-1 and TNF α in the blood of HIV patients. Cytokine production was measured in whole blood samples stimulated with LPS in the presence or absence of α-MSH (1–13), α-MSH (11–13), ACTH (1–24), or ACTH (1–39). Melanocortins reduced production of both cytokines in a concentration-dependent fashion. In separate experiments on normal peripheral blood mononuclear cells (PBMC), α-MSH (1–13) inhibited production of IL-1 β and TNF α induced by HIV envelope glycoprotein gp 120. These results suggest that stimulation of melanocortin receptors in inflammatory cells could be a novel way to reduce production of cytokines that promote HIV replication.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/S0196-9781(98)00055-2</identifier><identifier>PMID: 9700761</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenocorticotropic hormone ; Adrenocorticotropic Hormone - pharmacology ; Adult ; AIDS/HIV ; alpha-MSH - pharmacology ; Cosyntropin - pharmacology ; Female ; HIV Envelope Protein gp120 - pharmacology ; HIV Infections - blood ; Human immunodeficiency virus ; Humans ; In Vitro Techniques ; Interleukin 1 ; Interleukin-1 - blood ; Male ; Melanocortin peptides ; Monocytes - drug effects ; Monocytes - metabolism ; TNF α ; Tumor Necrosis Factor-alpha - metabolism ; α-melanocyte-stimulating hormone</subject><ispartof>Peptides (New York, N.Y. : 1980), 1998-01, Vol.19 (6), p.1099-1104</ispartof><rights>1998 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-70a911dde724f1122abc8383ea69e8bb95e26a805ef031b0db91d663232067033</citedby><cites>FETCH-LOGICAL-c509t-70a911dde724f1122abc8383ea69e8bb95e26a805ef031b0db91d663232067033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0196-9781(98)00055-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9700761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Catania, Anna</creatorcontrib><creatorcontrib>Garofalo, Letizia</creatorcontrib><creatorcontrib>Cutuli, Mariagrazia</creatorcontrib><creatorcontrib>Gringeri, Alessandro</creatorcontrib><creatorcontrib>Santagostino, Elena</creatorcontrib><creatorcontrib>Lipton, James M.</creatorcontrib><title>Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Melanocortins are proopiomelanocortin-derived peptides that include adrenocorticotropic hormone [ACTH (1–39)], α-melanocyte-stimulating hormone [α-MSH (1–13)], and related amino acid sequences. Melanocortin peptides have potent antiinflammatory/anticytokine activity. Because cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF) can be detrimental in HIV-infected patients, we investigated the effects of melanocortins on production of IL-1 and TNF α in the blood of HIV patients. Cytokine production was measured in whole blood samples stimulated with LPS in the presence or absence of α-MSH (1–13), α-MSH (11–13), ACTH (1–24), or ACTH (1–39). Melanocortins reduced production of both cytokines in a concentration-dependent fashion. In separate experiments on normal peripheral blood mononuclear cells (PBMC), α-MSH (1–13) inhibited production of IL-1 β and TNF α induced by HIV envelope glycoprotein gp 120. These results suggest that stimulation of melanocortin receptors in inflammatory cells could be a novel way to reduce production of cytokines that promote HIV replication.</description><subject>Adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>alpha-MSH - pharmacology</subject><subject>Cosyntropin - pharmacology</subject><subject>Female</subject><subject>HIV Envelope Protein gp120 - pharmacology</subject><subject>HIV Infections - blood</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Interleukin 1</subject><subject>Interleukin-1 - blood</subject><subject>Male</subject><subject>Melanocortin peptides</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>TNF α</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>α-melanocyte-stimulating hormone</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQRi0EKpfSn1ApKwSLgMdO_FghVNGHVMQC6NZy7AkYkjjYvkj33-P7ULddWdac8YzPR8gl0PdAQXz4RkGLVksFb7V6Rynt-5Y9IxtQkrc9CP2cbB6Rl-RVzr8r1HVanZEzLSmVAjbk5xec7BJdTCUszYprCR5zE5ZfYQilWVP0W1dCXJo47m9hGSc7z7bEtGvcrsQ_YTnwzTDF6PfU7d1DWzF0BX2z2hJwKfk1eTHaKePF6TwnP64_f7-6be-_3txdfbpvXU91aSW1GsB7lKwbARizg1NccbRCoxoG3SMTVtEeR8phoH7Q4IXgjDMqJOX8nLw5vlt3_bvFXMwcssOpfhLjNhvJFeu4hCdBEJ2SGmQF-yPoUsw54WjWFGabdgao2SdhDkmYvWajlTkkYVjtuzwN2A4z-seuk_pa_3isY9XxL2Ay2VVVDn1I1Z3xMTwx4T92Pplq</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Catania, Anna</creator><creator>Garofalo, Letizia</creator><creator>Cutuli, Mariagrazia</creator><creator>Gringeri, Alessandro</creator><creator>Santagostino, Elena</creator><creator>Lipton, James M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980101</creationdate><title>Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients</title><author>Catania, Anna ; Garofalo, Letizia ; Cutuli, Mariagrazia ; Gringeri, Alessandro ; Santagostino, Elena ; Lipton, James M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-70a911dde724f1122abc8383ea69e8bb95e26a805ef031b0db91d663232067033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>alpha-MSH - pharmacology</topic><topic>Cosyntropin - pharmacology</topic><topic>Female</topic><topic>HIV Envelope Protein gp120 - pharmacology</topic><topic>HIV Infections - blood</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Interleukin 1</topic><topic>Interleukin-1 - blood</topic><topic>Male</topic><topic>Melanocortin peptides</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - metabolism</topic><topic>TNF α</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>α-melanocyte-stimulating hormone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catania, Anna</creatorcontrib><creatorcontrib>Garofalo, Letizia</creatorcontrib><creatorcontrib>Cutuli, Mariagrazia</creatorcontrib><creatorcontrib>Gringeri, Alessandro</creatorcontrib><creatorcontrib>Santagostino, Elena</creatorcontrib><creatorcontrib>Lipton, James M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catania, Anna</au><au>Garofalo, Letizia</au><au>Cutuli, Mariagrazia</au><au>Gringeri, Alessandro</au><au>Santagostino, Elena</au><au>Lipton, James M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>19</volume><issue>6</issue><spage>1099</spage><epage>1104</epage><pages>1099-1104</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>Melanocortins are proopiomelanocortin-derived peptides that include adrenocorticotropic hormone [ACTH (1–39)], α-melanocyte-stimulating hormone [α-MSH (1–13)], and related amino acid sequences. Melanocortin peptides have potent antiinflammatory/anticytokine activity. Because cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF) can be detrimental in HIV-infected patients, we investigated the effects of melanocortins on production of IL-1 and TNF α in the blood of HIV patients. Cytokine production was measured in whole blood samples stimulated with LPS in the presence or absence of α-MSH (1–13), α-MSH (11–13), ACTH (1–24), or ACTH (1–39). Melanocortins reduced production of both cytokines in a concentration-dependent fashion. In separate experiments on normal peripheral blood mononuclear cells (PBMC), α-MSH (1–13) inhibited production of IL-1 β and TNF α induced by HIV envelope glycoprotein gp 120. These results suggest that stimulation of melanocortin receptors in inflammatory cells could be a novel way to reduce production of cytokines that promote HIV replication.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9700761</pmid><doi>10.1016/S0196-9781(98)00055-2</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1998-01, Vol.19 (6), p.1099-1104 |
| issn | 0196-9781 1873-5169 |
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| subjects | Adrenocorticotropic hormone Adrenocorticotropic Hormone - pharmacology Adult AIDS/HIV alpha-MSH - pharmacology Cosyntropin - pharmacology Female HIV Envelope Protein gp120 - pharmacology HIV Infections - blood Human immunodeficiency virus Humans In Vitro Techniques Interleukin 1 Interleukin-1 - blood Male Melanocortin peptides Monocytes - drug effects Monocytes - metabolism TNF α Tumor Necrosis Factor-alpha - metabolism α-melanocyte-stimulating hormone |
| title | Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients |
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