Schistosoma mansoni: Neurotransmitters, longitudinal musculature and effects of electrical stimulation
Longitudinal muscle shortening of adult male Schistosoma mansoni is produced by electrical stimulation. Responses are frequency and strength dependent. Neither 5-hydroxytryptamine (5-HT) antagonists nor dopamine interfere with the response. 5-HT does not enhance it. Carbachol (10 −4 M), eserine (10...
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| Veröffentlicht in: | Experimental parasitology 1981-01, Vol.52 (3), p.346-355 |
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| container_title | Experimental parasitology |
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| creator | Pax, R.A. Siefker, C. Hickox, T. Bennett, J.L. |
| description | Longitudinal muscle shortening of adult male
Schistosoma mansoni is produced by electrical stimulation. Responses are frequency and strength dependent. Neither 5-hydroxytryptamine (5-HT) antagonists nor dopamine interfere with the response. 5-HT does not enhance it. Carbachol (10
−4
M), eserine (10
−6
M), and metrifonate (10
−5
M) block the response but acetylcholine alone has no affect. Atropine (10
−4
M) partially counteracts the effects of carbachol. Hyperosmotic sucrose but not urea blocks the stimulation response. It is concluded that the response is nonneuronally conducted via a pathway involving gap junctions and that neurotransmitters probably act as modulators of motor activity rather than as initiators of it. |
| doi_str_mv | 10.1016/0014-4894(81)90092-8 |
| format | Article |
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Schistosoma mansoni is produced by electrical stimulation. Responses are frequency and strength dependent. Neither 5-hydroxytryptamine (5-HT) antagonists nor dopamine interfere with the response. 5-HT does not enhance it. Carbachol (10
−4
M), eserine (10
−6
M), and metrifonate (10
−5
M) block the response but acetylcholine alone has no affect. Atropine (10
−4
M) partially counteracts the effects of carbachol. Hyperosmotic sucrose but not urea blocks the stimulation response. It is concluded that the response is nonneuronally conducted via a pathway involving gap junctions and that neurotransmitters probably act as modulators of motor activity rather than as initiators of it.</description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/0014-4894(81)90092-8</identifier><identifier>PMID: 6119224</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acetylcholine - pharmacology ; Animals ; Blood fluke ; Carbachol - pharmacology ; Dopamine - pharmacology ; Electric Stimulation ; Locomotion and motility ; Male ; Muscle Contraction - drug effects ; Muscles, Trematoda ; Muscular activity ; Nervous system, Trematoda ; Neurotransmitter Agents - physiology ; Neurotransmitters ; Osmolar Concentration ; Physiology, Trematoda ; Physostigmine - pharmacology ; Schistosoma mansoni ; Schistosoma mansoni - physiology ; Serotonin - pharmacology ; Serotonin Antagonists - pharmacology ; Trematode ; Trichlorfon - pharmacology</subject><ispartof>Experimental parasitology, 1981-01, Vol.52 (3), p.346-355</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-3e098bcde34c0bd29d644da040ea4b72de8359203a50231fdd161b75fafdd4e53</citedby><cites>FETCH-LOGICAL-c381t-3e098bcde34c0bd29d644da040ea4b72de8359203a50231fdd161b75fafdd4e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014489481900928$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6119224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pax, R.A.</creatorcontrib><creatorcontrib>Siefker, C.</creatorcontrib><creatorcontrib>Hickox, T.</creatorcontrib><creatorcontrib>Bennett, J.L.</creatorcontrib><title>Schistosoma mansoni: Neurotransmitters, longitudinal musculature and effects of electrical stimulation</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description>Longitudinal muscle shortening of adult male
Schistosoma mansoni is produced by electrical stimulation. Responses are frequency and strength dependent. Neither 5-hydroxytryptamine (5-HT) antagonists nor dopamine interfere with the response. 5-HT does not enhance it. Carbachol (10
−4
M), eserine (10
−6
M), and metrifonate (10
−5
M) block the response but acetylcholine alone has no affect. Atropine (10
−4
M) partially counteracts the effects of carbachol. Hyperosmotic sucrose but not urea blocks the stimulation response. It is concluded that the response is nonneuronally conducted via a pathway involving gap junctions and that neurotransmitters probably act as modulators of motor activity rather than as initiators of it.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Blood fluke</subject><subject>Carbachol - pharmacology</subject><subject>Dopamine - pharmacology</subject><subject>Electric Stimulation</subject><subject>Locomotion and motility</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscles, Trematoda</subject><subject>Muscular activity</subject><subject>Nervous system, Trematoda</subject><subject>Neurotransmitter Agents - physiology</subject><subject>Neurotransmitters</subject><subject>Osmolar Concentration</subject><subject>Physiology, Trematoda</subject><subject>Physostigmine - pharmacology</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - physiology</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Trematode</subject><subject>Trichlorfon - pharmacology</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LHTEQhkOp2KP1H7R0r0Sh204-zm7iRaGIVkHaC-t1yCYTm7K70SQr9N83x3Pw0quZ4X1mGB5CPlD4QoF2XwGoaIVU4kTSUwWgWCvfkBUFBS0TQr0lqxfkHTnI-S8ASMrEPtnvKFWMiRXxt_ZPyCXmOJlmMnOOczhrfuKSYkl1nEIpmPLnZozzfSiLC7MZm2nJdhlNWRI2ZnYNeo-25Cb6BsfapWArlUuYNlSI83uy582Y8WhXD8nd5cXv86v25teP6_PvN63lkpaWIyg5WIdcWBgcU64TwhkQgEYMPXMo-Vox4GYNjFPvHO3o0K-9qa3ANT8kx9u7Dyk-LpiLnkK2OI5mxrhk3XPJuBB9BcUWtCnmnNDrhxQmk_5pCnqjV2_c6Y07Lal-1qtlXfu4u78ME7qXpZ3Pmn_a5t5Ebe5TyPrulgHlwDoqe9FV4tuWwKrhKWDS2QacLbqQqjntYnj9hf9a8JVm</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Pax, R.A.</creator><creator>Siefker, C.</creator><creator>Hickox, T.</creator><creator>Bennett, J.L.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810101</creationdate><title>Schistosoma mansoni: Neurotransmitters, longitudinal musculature and effects of electrical stimulation</title><author>Pax, R.A. ; Siefker, C. ; Hickox, T. ; Bennett, J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-3e098bcde34c0bd29d644da040ea4b72de8359203a50231fdd161b75fafdd4e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Blood fluke</topic><topic>Carbachol - pharmacology</topic><topic>Dopamine - pharmacology</topic><topic>Electric Stimulation</topic><topic>Locomotion and motility</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscles, Trematoda</topic><topic>Muscular activity</topic><topic>Nervous system, Trematoda</topic><topic>Neurotransmitter Agents - physiology</topic><topic>Neurotransmitters</topic><topic>Osmolar Concentration</topic><topic>Physiology, Trematoda</topic><topic>Physostigmine - pharmacology</topic><topic>Schistosoma mansoni</topic><topic>Schistosoma mansoni - physiology</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Trematode</topic><topic>Trichlorfon - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pax, R.A.</creatorcontrib><creatorcontrib>Siefker, C.</creatorcontrib><creatorcontrib>Hickox, T.</creatorcontrib><creatorcontrib>Bennett, J.L.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pax, R.A.</au><au>Siefker, C.</au><au>Hickox, T.</au><au>Bennett, J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schistosoma mansoni: Neurotransmitters, longitudinal musculature and effects of electrical stimulation</atitle><jtitle>Experimental parasitology</jtitle><addtitle>Exp Parasitol</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>52</volume><issue>3</issue><spage>346</spage><epage>355</epage><pages>346-355</pages><issn>0014-4894</issn><eissn>1090-2449</eissn><abstract>Longitudinal muscle shortening of adult male
Schistosoma mansoni is produced by electrical stimulation. Responses are frequency and strength dependent. Neither 5-hydroxytryptamine (5-HT) antagonists nor dopamine interfere with the response. 5-HT does not enhance it. Carbachol (10
−4
M), eserine (10
−6
M), and metrifonate (10
−5
M) block the response but acetylcholine alone has no affect. Atropine (10
−4
M) partially counteracts the effects of carbachol. Hyperosmotic sucrose but not urea blocks the stimulation response. It is concluded that the response is nonneuronally conducted via a pathway involving gap junctions and that neurotransmitters probably act as modulators of motor activity rather than as initiators of it.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6119224</pmid><doi>10.1016/0014-4894(81)90092-8</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4894 |
| ispartof | Experimental parasitology, 1981-01, Vol.52 (3), p.346-355 |
| issn | 0014-4894 1090-2449 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73823447 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholine - pharmacology Animals Blood fluke Carbachol - pharmacology Dopamine - pharmacology Electric Stimulation Locomotion and motility Male Muscle Contraction - drug effects Muscles, Trematoda Muscular activity Nervous system, Trematoda Neurotransmitter Agents - physiology Neurotransmitters Osmolar Concentration Physiology, Trematoda Physostigmine - pharmacology Schistosoma mansoni Schistosoma mansoni - physiology Serotonin - pharmacology Serotonin Antagonists - pharmacology Trematode Trichlorfon - pharmacology |
| title | Schistosoma mansoni: Neurotransmitters, longitudinal musculature and effects of electrical stimulation |
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