Polyclonal immunoglobulin G deposition disease: A unique entity
We report a unique case of tubular polyclonal immunoglobulin G (IgG) deposition disease (PIDD) superimposed on diabetic nephropathy in an 84- year-old man presenting with subacute renal failure and proteinuria. The deposits were located exclusively between the tubular epithelial cells and the tubula...
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| Veröffentlicht in: | American journal of kidney diseases 1998-08, Vol.32 (2), p.328-333 |
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| container_title | American journal of kidney diseases |
| container_volume | 32 |
| creator | Markowitz, GS Fine, PL Kunis, CL Yu, Z D'Agati, VD |
| description | We report a unique case of tubular polyclonal immunoglobulin G (IgG) deposition disease (PIDD) superimposed on diabetic nephropathy in an 84- year-old man presenting with subacute renal failure and proteinuria. The deposits were located exclusively between the tubular epithelial cells and the tubular basement membranes (TBMs) and stained intensely with antisera to IgG heavy chain and both kappa and lambda light chains. Electron microscopy revealed large predominantly extracellular electron-dense deposits with a distinctive curvilinear substructure. The associated light microscopic findings of tubular simplification with features of acute tubular necrosis implicate this tubulopathy as the cause of the acute renal failure. This appears to represent a unique entity that does not fit into any previously described category of renal tubular immune complex or immunoglobulin deposition disease. (Am J Kidney Dis 1998 Aug;32(2):328-33) |
| doi_str_mv | 10.1053/ajkd.1998.v32.pm9708622 |
| format | Article |
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The deposits were located exclusively between the tubular epithelial cells and the tubular basement membranes (TBMs) and stained intensely with antisera to IgG heavy chain and both kappa and lambda light chains. Electron microscopy revealed large predominantly extracellular electron-dense deposits with a distinctive curvilinear substructure. The associated light microscopic findings of tubular simplification with features of acute tubular necrosis implicate this tubulopathy as the cause of the acute renal failure. This appears to represent a unique entity that does not fit into any previously described category of renal tubular immune complex or immunoglobulin deposition disease. (Am J Kidney Dis 1998 Aug;32(2):328-33)</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/ajkd.1998.v32.pm9708622</identifier><identifier>PMID: 9708622</identifier><language>eng</language><publisher>Orlando, FL: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Diabetic Nephropathies - complications ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin G - metabolism ; Kidney Tubules - immunology ; Kidney Tubules - pathology ; Male ; Medical sciences ; Microscopy, Electron ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Renal Insufficiency - immunology ; Renal Insufficiency - pathology ; Tubulopathies</subject><ispartof>American journal of kidney diseases, 1998-08, Vol.32 (2), p.328-333</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-2be48350f912428fe3b994b78161e50fc2c19170d3bcefe42a2d617b5168e1f23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0272638698002200$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2344839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9708622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markowitz, GS</creatorcontrib><creatorcontrib>Fine, PL</creatorcontrib><creatorcontrib>Kunis, CL</creatorcontrib><creatorcontrib>Yu, Z</creatorcontrib><creatorcontrib>D'Agati, VD</creatorcontrib><title>Polyclonal immunoglobulin G deposition disease: A unique entity</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>We report a unique case of tubular polyclonal immunoglobulin G (IgG) deposition disease (PIDD) superimposed on diabetic nephropathy in an 84- year-old man presenting with subacute renal failure and proteinuria. The deposits were located exclusively between the tubular epithelial cells and the tubular basement membranes (TBMs) and stained intensely with antisera to IgG heavy chain and both kappa and lambda light chains. Electron microscopy revealed large predominantly extracellular electron-dense deposits with a distinctive curvilinear substructure. The associated light microscopic findings of tubular simplification with features of acute tubular necrosis implicate this tubulopathy as the cause of the acute renal failure. This appears to represent a unique entity that does not fit into any previously described category of renal tubular immune complex or immunoglobulin deposition disease. (Am J Kidney Dis 1998 Aug;32(2):328-33)</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Diabetic Nephropathies - complications</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Immunoglobulin G - metabolism</subject><subject>Kidney Tubules - immunology</subject><subject>Kidney Tubules - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Renal Insufficiency - immunology</subject><subject>Renal Insufficiency - pathology</subject><subject>Tubulopathies</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LwzAUwIMoc07_BLEH8daZjzZNvMgYOoWBHvQc0vRVMtNkNu1g_70dG_Po6cF7v_f1Q-iG4CnBObvXq-9qSqQU0w2j03UjCyw4pSdoTHLKUi6YOEVjTAuacib4ObqIcYUxlozzERod8DF6fA9ua1zw2iW2aXofvlwoe2d9skgqWIdoOxt8UtkIOsJDMkt6b396SMB3ttteorNauwhXhzhBn89PH_OXdPm2eJ3PlqlhMu9SWkImWI5rSWhGRQ2slDIrC0E4gSFtqCGSFLhipYEaMqppxUlR5oQLIDVlE3S3n7tuw7A9dqqx0YBz2kPooyqYoIwW-QAWe9C0IcYWarVubaPbrSJY7dSpnTq1U6cGdeqobui8PqzoywaqY99f_fZQ19FoV7faGxuPGGXZ8KIcsNkeg0HHxkKrorHgDVS2BdOpKth_T_kFadKOiQ</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Markowitz, GS</creator><creator>Fine, PL</creator><creator>Kunis, CL</creator><creator>Yu, Z</creator><creator>D'Agati, VD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Polyclonal immunoglobulin G deposition disease: A unique entity</title><author>Markowitz, GS ; Fine, PL ; Kunis, CL ; Yu, Z ; D'Agati, VD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-2be48350f912428fe3b994b78161e50fc2c19170d3bcefe42a2d617b5168e1f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Diabetic Nephropathies - complications</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunoglobulin G - metabolism</topic><topic>Kidney Tubules - immunology</topic><topic>Kidney Tubules - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Renal Insufficiency - immunology</topic><topic>Renal Insufficiency - pathology</topic><topic>Tubulopathies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markowitz, GS</creatorcontrib><creatorcontrib>Fine, PL</creatorcontrib><creatorcontrib>Kunis, CL</creatorcontrib><creatorcontrib>Yu, Z</creatorcontrib><creatorcontrib>D'Agati, VD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markowitz, GS</au><au>Fine, PL</au><au>Kunis, CL</au><au>Yu, Z</au><au>D'Agati, VD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyclonal immunoglobulin G deposition disease: A unique entity</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>32</volume><issue>2</issue><spage>328</spage><epage>333</epage><pages>328-333</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>We report a unique case of tubular polyclonal immunoglobulin G (IgG) deposition disease (PIDD) superimposed on diabetic nephropathy in an 84- year-old man presenting with subacute renal failure and proteinuria. The deposits were located exclusively between the tubular epithelial cells and the tubular basement membranes (TBMs) and stained intensely with antisera to IgG heavy chain and both kappa and lambda light chains. Electron microscopy revealed large predominantly extracellular electron-dense deposits with a distinctive curvilinear substructure. The associated light microscopic findings of tubular simplification with features of acute tubular necrosis implicate this tubulopathy as the cause of the acute renal failure. This appears to represent a unique entity that does not fit into any previously described category of renal tubular immune complex or immunoglobulin deposition disease. (Am J Kidney Dis 1998 Aug;32(2):328-33)</abstract><cop>Orlando, FL</cop><pub>Elsevier Inc</pub><pmid>9708622</pmid><doi>10.1053/ajkd.1998.v32.pm9708622</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0272-6386 |
| ispartof | American journal of kidney diseases, 1998-08, Vol.32 (2), p.328-333 |
| issn | 0272-6386 1523-6838 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Biological and medical sciences Diabetic Nephropathies - complications Fluorescent Antibody Technique Humans Immunoglobulin G - metabolism Kidney Tubules - immunology Kidney Tubules - pathology Male Medical sciences Microscopy, Electron Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Renal Insufficiency - immunology Renal Insufficiency - pathology Tubulopathies |
| title | Polyclonal immunoglobulin G deposition disease: A unique entity |
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