Interaction of Tablet Disintegrants and Magnesium Stearate during Mixing I: Effect on Tablet Disintegration

The effect of magnesium stearate on the disintegration of tablets was studied. Three different preblends, containing a slightly or a strongly swelling disintegrant, were mixed before compression with magnesium stearate for different time periods. The results show that a strongly swelling disintegran...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1981-12, Vol.70 (12), p.1328-1330
Hauptverfasser:	Bolhuis, G.K., Smallenbroek, A.J., Lerk, C.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspirin Calcium Phosphates Disintegration-tablets Disintegration—tablets, effect of magnesium stearate luring mixing Drug Compounding effect of magnesium stearate luring mixing Excipients Hardness Lactose Magnesium stearate-effect on tablet disintegration luring mixing Solubility Starch Stearic Acids Tablets Tablets-disintegration Tablets—disintegration, effect of magnesium stearate luring mixing
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