Interaction of Tablet Disintegrants and Magnesium Stearate during Mixing I: Effect on Tablet Disintegration
The effect of magnesium stearate on the disintegration of tablets was studied. Three different preblends, containing a slightly or a strongly swelling disintegrant, were mixed before compression with magnesium stearate for different time periods. The results show that a strongly swelling disintegran...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1981-12, Vol.70 (12), p.1328-1330 |
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| container_issue | 12 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 70 |
| creator | Bolhuis, G.K. Smallenbroek, A.J. Lerk, C.F. |
| description | The effect of magnesium stearate on the disintegration of tablets was studied. Three different preblends, containing a slightly or a strongly swelling disintegrant, were mixed before compression with magnesium stearate for different time periods. The results show that a strongly swelling disintegrant, such as sodium starch glycolate in contrast to potato starch, can reduce the deteriorating effect of hydrophobic lubricants on tablet disintegration. However, the interaction between magnesium stearate and potato starch or sodium starch glycolate and he resulting differences in disintegration characteristics can be masked by the use of disks in the USP disintegration apparatus. |
| doi_str_mv | 10.1002/jps.2600701210 |
| format | Article |
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Three different preblends, containing a slightly or a strongly swelling disintegrant, were mixed before compression with magnesium stearate for different time periods. The results show that a strongly swelling disintegrant, such as sodium starch glycolate in contrast to potato starch, can reduce the deteriorating effect of hydrophobic lubricants on tablet disintegration. 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Pharm. Sci</addtitle><description>The effect of magnesium stearate on the disintegration of tablets was studied. Three different preblends, containing a slightly or a strongly swelling disintegrant, were mixed before compression with magnesium stearate for different time periods. The results show that a strongly swelling disintegrant, such as sodium starch glycolate in contrast to potato starch, can reduce the deteriorating effect of hydrophobic lubricants on tablet disintegration. However, the interaction between magnesium stearate and potato starch or sodium starch glycolate and he resulting differences in disintegration characteristics can be masked by the use of disks in the USP disintegration apparatus.</description><subject>Aspirin</subject><subject>Calcium Phosphates</subject><subject>Disintegration-tablets</subject><subject>Disintegration—tablets, effect of magnesium stearate luring mixing</subject><subject>Drug Compounding</subject><subject>effect of magnesium stearate luring mixing</subject><subject>Excipients</subject><subject>Hardness</subject><subject>Lactose</subject><subject>Magnesium stearate-effect on tablet disintegration luring mixing</subject><subject>Solubility</subject><subject>Starch</subject><subject>Stearic Acids</subject><subject>Tablets</subject><subject>Tablets-disintegration</subject><subject>Tablets—disintegration, effect of magnesium stearate luring mixing</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFv0zAUhy0EGmVw5YbkE7d0z7ETJ9xQt25FKyA2hMTFcpznyluaFNuB7b-fq1RDCCFO7_D73qfnnwl5zWDOAPKTm12Y5yWABJYzeEJmrMghK4HJp2SWgDzjhaifkxch3ABACUVxRI4kz6ES5YzcrvqIXpvohp4Oll7rpsNIT11wKdh43cdAdd_Std70GNy4pVcRtdcRaTt612_o2t3tx-odPbMWTaTJ9Jdm739JnlndBXx1mMfk6_LsenGRXX46Xy3eX2ZGQJVub0pE00AjBJOFaJFbyXVTWFEyw006u2prXtcVE9pyLDkyU0tsi6bhVnDLj8nbybvzw48RQ1RbFwx2ne5xGIOSvGI11JDA-QQaP4Tg0aqdd1vt7xUDtW9XpXbV73bTwpuDeWy22D7ihzpTXk_5L9fh_X9s6sPnqz_c2bTrQsS7x13tb1UpuSzUt4_n6vs6X7KLL0u1SHw18Ziq_OnQq2Ac9gZb59MvqHZw_3rGA0CmqMg</recordid><startdate>198112</startdate><enddate>198112</enddate><creator>Bolhuis, G.K.</creator><creator>Smallenbroek, A.J.</creator><creator>Lerk, C.F.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198112</creationdate><title>Interaction of Tablet Disintegrants and Magnesium Stearate during Mixing I: Effect on Tablet Disintegration</title><author>Bolhuis, G.K. ; Smallenbroek, A.J. ; Lerk, C.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4080-6b6eecb0b441754de3f73ab5f461c3c8468d9399814af3e63e1c97ed5bb3f43f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Aspirin</topic><topic>Calcium Phosphates</topic><topic>Disintegration-tablets</topic><topic>Disintegration—tablets, effect of magnesium stearate luring mixing</topic><topic>Drug Compounding</topic><topic>effect of magnesium stearate luring mixing</topic><topic>Excipients</topic><topic>Hardness</topic><topic>Lactose</topic><topic>Magnesium stearate-effect on tablet disintegration luring mixing</topic><topic>Solubility</topic><topic>Starch</topic><topic>Stearic Acids</topic><topic>Tablets</topic><topic>Tablets-disintegration</topic><topic>Tablets—disintegration, effect of magnesium stearate luring mixing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bolhuis, G.K.</creatorcontrib><creatorcontrib>Smallenbroek, A.J.</creatorcontrib><creatorcontrib>Lerk, C.F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolhuis, G.K.</au><au>Smallenbroek, A.J.</au><au>Lerk, C.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of Tablet Disintegrants and Magnesium Stearate during Mixing I: Effect on Tablet Disintegration</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1981-12</date><risdate>1981</risdate><volume>70</volume><issue>12</issue><spage>1328</spage><epage>1330</epage><pages>1328-1330</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The effect of magnesium stearate on the disintegration of tablets was studied. Three different preblends, containing a slightly or a strongly swelling disintegrant, were mixed before compression with magnesium stearate for different time periods. The results show that a strongly swelling disintegrant, such as sodium starch glycolate in contrast to potato starch, can reduce the deteriorating effect of hydrophobic lubricants on tablet disintegration. However, the interaction between magnesium stearate and potato starch or sodium starch glycolate and he resulting differences in disintegration characteristics can be masked by the use of disks in the USP disintegration apparatus.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7320846</pmid><doi>10.1002/jps.2600701210</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1981-12, Vol.70 (12), p.1328-1330 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Aspirin Calcium Phosphates Disintegration-tablets Disintegration—tablets, effect of magnesium stearate luring mixing Drug Compounding effect of magnesium stearate luring mixing Excipients Hardness Lactose Magnesium stearate-effect on tablet disintegration luring mixing Solubility Starch Stearic Acids Tablets Tablets-disintegration Tablets—disintegration, effect of magnesium stearate luring mixing |
| title | Interaction of Tablet Disintegrants and Magnesium Stearate during Mixing I: Effect on Tablet Disintegration |
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