Effect of Pirprofen on Protein Binding of Warfarin and Tolbutamide in Human Plasma
The extent of warfarin and tolbutamide binding to plasma proteins was determined with and without pirprofen by an ultrafiltration procedure employing14C‐labeled drugs. Results fromin vitrostudies at 37° showed that the degree of binding amounted to 97.8% for warfarin and 95.6% for tolbutamide. The b...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1981-12, Vol.70 (12), p.1370-1371 |
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| container_end_page | 1371 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 70 |
| creator | Luders, Richard C. Chao, Dolly |
| description | The extent of warfarin and tolbutamide binding to plasma proteins was determined with and without pirprofen by an ultrafiltration procedure employing14C‐labeled drugs. Results fromin vitrostudies at 37° showed that the degree of binding amounted to 97.8% for warfarin and 95.6% for tolbutamide. The binding characteristics of these drugs were not altered when plasma containing either warfarin or tolbutamide at concentrations equivalent to those expected normally after therapeutic dosing were concomitantly spiked with therapeutic amounts of pirprofen. Consequently, potentiation resulting from drug displacement would not be anticipated in humans when pirprofen is administered along with warfarin or tolbutamide. |
| doi_str_mv | 10.1002/jps.2600701221 |
| format | Article |
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Results fromin vitrostudies at 37° showed that the degree of binding amounted to 97.8% for warfarin and 95.6% for tolbutamide. The binding characteristics of these drugs were not altered when plasma containing either warfarin or tolbutamide at concentrations equivalent to those expected normally after therapeutic dosing were concomitantly spiked with therapeutic amounts of pirprofen. Consequently, potentiation resulting from drug displacement would not be anticipated in humans when pirprofen is administered along with warfarin or tolbutamide.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600701221</identifier><identifier>PMID: 7320855</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Anti-Inflammatory Agents - pharmacology ; Binding ; Binding, protein—tolbutamide and warfarin ; Humans ; In Vitro Techniques ; Phenylpropionates - pharmacology ; Pirprofen-effect on protein binding of warfarin and tolbutamide ; Protein Binding - drug effects ; protein-tolbutamide and warfarin ; Pyrroles - pharmacology ; Temperature ; Tolbutamide - blood ; Tolbutamide-protein binding in presence of pirprofen ; Warfarin - blood ; Warfarin-protein binding in presence of pirprofen</subject><ispartof>Journal of pharmaceutical sciences, 1981-12, Vol.70 (12), p.1370-1371</ispartof><rights>1981 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1981 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4581-d1b2dbc9722aebf1190c81599dfd07982523bed22bcc8566584f14331ddbbff13</citedby><cites>FETCH-LOGICAL-c4581-d1b2dbc9722aebf1190c81599dfd07982523bed22bcc8566584f14331ddbbff13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600701221$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600701221$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7320855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luders, Richard C.</creatorcontrib><creatorcontrib>Chao, Dolly</creatorcontrib><title>Effect of Pirprofen on Protein Binding of Warfarin and Tolbutamide in Human Plasma</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The extent of warfarin and tolbutamide binding to plasma proteins was determined with and without pirprofen by an ultrafiltration procedure employing14C‐labeled drugs. Results fromin vitrostudies at 37° showed that the degree of binding amounted to 97.8% for warfarin and 95.6% for tolbutamide. The binding characteristics of these drugs were not altered when plasma containing either warfarin or tolbutamide at concentrations equivalent to those expected normally after therapeutic dosing were concomitantly spiked with therapeutic amounts of pirprofen. Consequently, potentiation resulting from drug displacement would not be anticipated in humans when pirprofen is administered along with warfarin or tolbutamide.</description><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Binding</subject><subject>Binding, protein—tolbutamide and warfarin</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Phenylpropionates - pharmacology</subject><subject>Pirprofen-effect on protein binding of warfarin and tolbutamide</subject><subject>Protein Binding - drug effects</subject><subject>protein-tolbutamide and warfarin</subject><subject>Pyrroles - pharmacology</subject><subject>Temperature</subject><subject>Tolbutamide - blood</subject><subject>Tolbutamide-protein binding in presence of pirprofen</subject><subject>Warfarin - blood</subject><subject>Warfarin-protein binding in presence of pirprofen</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EKkvhyg0pJ25ZPHYcJ0eoShe6ghUUerT8MUYu-VjsBOh_j1dZFXFAPVma93tPnjeEPAe6BkrZq5t9WrOaUkmBMXhAViAYLWsK8iFZZYCVXFTtY_IkpRtKaU2FOCEnkjPaCLEin869RzsVoy92Ie7j6HEoxqHYxXHCMBRvwuDC8O2gX-vodcwzPbjiauzMPOk-OCzyaDP3Ops6nXr9lDzyukv47Pieki9vz6_ONuX248W7s9fb0laigdKBYc7YVjKm0XiAltoGRNs676hsGyYYN-gYM9Y2oq5FU3moOAfnjPEe-Cl5ueTmX_-YMU2qD8li1-kBxzkpyRuQDfB7QRCVlDVjGVwvoI1jShG92sfQ63irgKpD2yq3rf62nQ0vjsmz6dHd4cd6s94u-q_Q4e09aer97vM_2eXiDWnC33deHb-rWnIp1PWHCyUvv9LLrdiow5bNwmPu_GfAqJINOFh0IeYLKzeG_63xB5PmrAw</recordid><startdate>198112</startdate><enddate>198112</enddate><creator>Luders, Richard C.</creator><creator>Chao, Dolly</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198112</creationdate><title>Effect of Pirprofen on Protein Binding of Warfarin and Tolbutamide in Human Plasma</title><author>Luders, Richard C. ; Chao, Dolly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4581-d1b2dbc9722aebf1190c81599dfd07982523bed22bcc8566584f14331ddbbff13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Binding</topic><topic>Binding, protein—tolbutamide and warfarin</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Phenylpropionates - pharmacology</topic><topic>Pirprofen-effect on protein binding of warfarin and tolbutamide</topic><topic>Protein Binding - drug effects</topic><topic>protein-tolbutamide and warfarin</topic><topic>Pyrroles - pharmacology</topic><topic>Temperature</topic><topic>Tolbutamide - blood</topic><topic>Tolbutamide-protein binding in presence of pirprofen</topic><topic>Warfarin - blood</topic><topic>Warfarin-protein binding in presence of pirprofen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luders, Richard C.</creatorcontrib><creatorcontrib>Chao, Dolly</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luders, Richard C.</au><au>Chao, Dolly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Pirprofen on Protein Binding of Warfarin and Tolbutamide in Human Plasma</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1981-12</date><risdate>1981</risdate><volume>70</volume><issue>12</issue><spage>1370</spage><epage>1371</epage><pages>1370-1371</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The extent of warfarin and tolbutamide binding to plasma proteins was determined with and without pirprofen by an ultrafiltration procedure employing14C‐labeled drugs. Results fromin vitrostudies at 37° showed that the degree of binding amounted to 97.8% for warfarin and 95.6% for tolbutamide. The binding characteristics of these drugs were not altered when plasma containing either warfarin or tolbutamide at concentrations equivalent to those expected normally after therapeutic dosing were concomitantly spiked with therapeutic amounts of pirprofen. Consequently, potentiation resulting from drug displacement would not be anticipated in humans when pirprofen is administered along with warfarin or tolbutamide.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7320855</pmid><doi>10.1002/jps.2600701221</doi><tpages>2</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1981-12, Vol.70 (12), p.1370-1371 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Anti-Inflammatory Agents - pharmacology Binding Binding, protein—tolbutamide and warfarin Humans In Vitro Techniques Phenylpropionates - pharmacology Pirprofen-effect on protein binding of warfarin and tolbutamide Protein Binding - drug effects protein-tolbutamide and warfarin Pyrroles - pharmacology Temperature Tolbutamide - blood Tolbutamide-protein binding in presence of pirprofen Warfarin - blood Warfarin-protein binding in presence of pirprofen |
| title | Effect of Pirprofen on Protein Binding of Warfarin and Tolbutamide in Human Plasma |
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