The effect of GABA antagonism on propulsive activity of the guinea-pig large intestine
Possible involvement of γ-aminobutyric acid (GABA) in intestinal motility of the guinea-pig has been investigated using the speed of propulsion of faecal pellets along isolated segments of guinea-pig distal colon, and the rate of pellet expulsion from freshly excised colon. GABA antagonism, by bicuc...
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| Veröffentlicht in: | European journal of pharmacology 1981-11, Vol.76 (1), p.111-114 |
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| container_title | European journal of pharmacology |
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| creator | Krantis, Anthony Kerr, David I.B. |
| description | Possible involvement of γ-aminobutyric acid (GABA) in intestinal motility of the guinea-pig has been investigated using the speed of propulsion of faecal pellets along isolated segments of guinea-pig distal colon, and the rate of pellet expulsion from freshly excised colon. GABA antagonism, by bicuculline or by tachyphylaxis to GABA, substantially reduced intestinal motility and generally reduced the amplitude of the reflex contraction associated with pellet propulsion. These results support the view that GABAergic mechanisms may be involved in the propulsive activity of the guinea-pig distal colon. |
| doi_str_mv | 10.1016/0014-2999(81)90018-2 |
| format | Article |
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GABA antagonism, by bicuculline or by tachyphylaxis to GABA, substantially reduced intestinal motility and generally reduced the amplitude of the reflex contraction associated with pellet propulsion. These results support the view that GABAergic mechanisms may be involved in the propulsive activity of the guinea-pig distal colon.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(81)90018-2</identifier><identifier>PMID: 7318919</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Bicuculline - pharmacology ; Colon - physiology ; Female ; GABA antagonism ; GABA Antagonists ; Gastrointestinal Motility - drug effects ; Guinea Pigs ; Intestinal motility ; Male ; Peristalsis - drug effects ; Peristaltic reflexes</subject><ispartof>European journal of pharmacology, 1981-11, Vol.76 (1), p.111-114</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-81fa0a24f23313e681dd05bd020ed90cc4c80f3d02aceaad6bb4fe378690bb283</citedby><cites>FETCH-LOGICAL-c423t-81fa0a24f23313e681dd05bd020ed90cc4c80f3d02aceaad6bb4fe378690bb283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(81)90018-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7318919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krantis, Anthony</creatorcontrib><creatorcontrib>Kerr, David I.B.</creatorcontrib><title>The effect of GABA antagonism on propulsive activity of the guinea-pig large intestine</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Possible involvement of γ-aminobutyric acid (GABA) in intestinal motility of the guinea-pig has been investigated using the speed of propulsion of faecal pellets along isolated segments of guinea-pig distal colon, and the rate of pellet expulsion from freshly excised colon. GABA antagonism, by bicuculline or by tachyphylaxis to GABA, substantially reduced intestinal motility and generally reduced the amplitude of the reflex contraction associated with pellet propulsion. These results support the view that GABAergic mechanisms may be involved in the propulsive activity of the guinea-pig distal colon.</description><subject>Animals</subject><subject>Bicuculline - pharmacology</subject><subject>Colon - physiology</subject><subject>Female</subject><subject>GABA antagonism</subject><subject>GABA Antagonists</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Guinea Pigs</subject><subject>Intestinal motility</subject><subject>Male</subject><subject>Peristalsis - drug effects</subject><subject>Peristaltic reflexes</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EKqXwByB5hWAR8CNN7A1SqaAgVWJT2FqOMw5GeREnlfr3OLRiyWo0M_fO4yB0SckdJTS5J4TGEZNS3gh6K0MmInaEplSkMiIpZcdo-ic5RWfefxFC5pLNJ2iScioklVP0sfkEDNaC6XFj8WrxuMC67nXR1M5XuKlx2zXtUHq3BaxN77au343KPviKwdWgo9YVuNRdAdjVPfg-FM_RidWlh4tDnKH356fN8iVav61el4t1ZGLG-0hQq4lmsWWcUw6JoHlO5llOGIFcEmNiI4jlIdcGtM6TLIst8FQkkmQZE3yGrvdzw5XfQ9itKucNlKWuoRm8SrmgSUJlEMZ7oeka7zuwqu1cpbudokSNONXISo2slKDqF6diwXZ1mD9kFeR_pgO_0H_Y9yE8uXXQKW8c1AZy1wWkKm_c_wt-AHx1hGc</recordid><startdate>19811119</startdate><enddate>19811119</enddate><creator>Krantis, Anthony</creator><creator>Kerr, David I.B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19811119</creationdate><title>The effect of GABA antagonism on propulsive activity of the guinea-pig large intestine</title><author>Krantis, Anthony ; Kerr, David I.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-81fa0a24f23313e681dd05bd020ed90cc4c80f3d02aceaad6bb4fe378690bb283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Bicuculline - pharmacology</topic><topic>Colon - physiology</topic><topic>Female</topic><topic>GABA antagonism</topic><topic>GABA Antagonists</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Guinea Pigs</topic><topic>Intestinal motility</topic><topic>Male</topic><topic>Peristalsis - drug effects</topic><topic>Peristaltic reflexes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krantis, Anthony</creatorcontrib><creatorcontrib>Kerr, David I.B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krantis, Anthony</au><au>Kerr, David I.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of GABA antagonism on propulsive activity of the guinea-pig large intestine</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1981-11-19</date><risdate>1981</risdate><volume>76</volume><issue>1</issue><spage>111</spage><epage>114</epage><pages>111-114</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Possible involvement of γ-aminobutyric acid (GABA) in intestinal motility of the guinea-pig has been investigated using the speed of propulsion of faecal pellets along isolated segments of guinea-pig distal colon, and the rate of pellet expulsion from freshly excised colon. GABA antagonism, by bicuculline or by tachyphylaxis to GABA, substantially reduced intestinal motility and generally reduced the amplitude of the reflex contraction associated with pellet propulsion. These results support the view that GABAergic mechanisms may be involved in the propulsive activity of the guinea-pig distal colon.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7318919</pmid><doi>10.1016/0014-2999(81)90018-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1981-11, Vol.76 (1), p.111-114 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73816619 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Bicuculline - pharmacology Colon - physiology Female GABA antagonism GABA Antagonists Gastrointestinal Motility - drug effects Guinea Pigs Intestinal motility Male Peristalsis - drug effects Peristaltic reflexes |
| title | The effect of GABA antagonism on propulsive activity of the guinea-pig large intestine |
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