The effect of IgG, F(ab')2 and serum on the glucose metabolism in human leucocytes
The glucose metabolism in human leucocytes was strongly stimulated by IgG, independent of whether phagocytosis occurred or not. The percentage increase was highest in the pentose phosphate pathway. Maximum stimulation of the glucose oxidation occurred with an IgG concentration of 1-4 g/l. The insign...
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| Veröffentlicht in: | Scandinavian journal of clinical and laboratory investigation 1981-05, Vol.41 (3), p.311-318 |
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| container_title | Scandinavian journal of clinical and laboratory investigation |
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| creator | Kjøsen, Berit Bassøe, Hans H. |
| description | The glucose metabolism in human leucocytes was strongly stimulated by IgG, independent of whether phagocytosis occurred or not. The percentage increase was highest in the pentose phosphate pathway. Maximum stimulation of the glucose oxidation occurred with an IgG concentration of 1-4 g/l. The insignificant effect of F(ab')2 fragments indicated that the Fc piece is necessary for the stimulation by IgG. In nonphagocytosing leucocytes, serum stimulated the lactate production more and the CO2 production less than indicated by the IgG content of the serum. During phagocytosis or with high IgG concentrations, serum increased the glucose oxidation to a greater extent than did IgG alone. These results indicate that IgG is one of the components in serum most important for the stimulation of glucose oxidation in leucocytes. Serum factors counteracting the stimulation of glucose oxidation by IgG in nonphagocytosing leucocytes may have a regulating effect in vivo. |
| doi_str_mv | 10.1080/00365518109092050 |
| format | Article |
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The percentage increase was highest in the pentose phosphate pathway. Maximum stimulation of the glucose oxidation occurred with an IgG concentration of 1-4 g/l. The insignificant effect of F(ab')2 fragments indicated that the Fc piece is necessary for the stimulation by IgG. In nonphagocytosing leucocytes, serum stimulated the lactate production more and the CO2 production less than indicated by the IgG content of the serum. During phagocytosis or with high IgG concentrations, serum increased the glucose oxidation to a greater extent than did IgG alone. These results indicate that IgG is one of the components in serum most important for the stimulation of glucose oxidation in leucocytes. Serum factors counteracting the stimulation of glucose oxidation by IgG in nonphagocytosing leucocytes may have a regulating effect in vivo.</description><identifier>ISSN: 0036-5513</identifier><identifier>EISSN: 1502-7686</identifier><identifier>DOI: 10.1080/00365518109092050</identifier><identifier>PMID: 6797034</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Blood ; Carbon Dioxide - metabolism ; Glucose - metabolism ; Humans ; Immunoglobulin Fab Fragments ; immunoglobulin G ; Immunoglobulin G - physiology ; In Vitro Techniques ; Lactates - metabolism ; Lactic Acid ; leucocytes ; Leukocytes - physiology ; Pentosephosphates - metabolism ; Phagocytosis</subject><ispartof>Scandinavian journal of clinical and laboratory investigation, 1981-05, Vol.41 (3), p.311-318</ispartof><rights>1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-e714aed8085bf1fb0e9f9eeec4128cdd20224db309998fa70278a10c18d607223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00365518109092050$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00365518109092050$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6797034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kjøsen, Berit</creatorcontrib><creatorcontrib>Bassøe, Hans H.</creatorcontrib><title>The effect of IgG, F(ab')2 and serum on the glucose metabolism in human leucocytes</title><title>Scandinavian journal of clinical and laboratory investigation</title><addtitle>Scand J Clin Lab Invest</addtitle><description>The glucose metabolism in human leucocytes was strongly stimulated by IgG, independent of whether phagocytosis occurred or not. The percentage increase was highest in the pentose phosphate pathway. Maximum stimulation of the glucose oxidation occurred with an IgG concentration of 1-4 g/l. The insignificant effect of F(ab')2 fragments indicated that the Fc piece is necessary for the stimulation by IgG. In nonphagocytosing leucocytes, serum stimulated the lactate production more and the CO2 production less than indicated by the IgG content of the serum. During phagocytosis or with high IgG concentrations, serum increased the glucose oxidation to a greater extent than did IgG alone. These results indicate that IgG is one of the components in serum most important for the stimulation of glucose oxidation in leucocytes. Serum factors counteracting the stimulation of glucose oxidation by IgG in nonphagocytosing leucocytes may have a regulating effect in vivo.</description><subject>Blood</subject><subject>Carbon Dioxide - metabolism</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Immunoglobulin Fab Fragments</subject><subject>immunoglobulin G</subject><subject>Immunoglobulin G - physiology</subject><subject>In Vitro Techniques</subject><subject>Lactates - metabolism</subject><subject>Lactic Acid</subject><subject>leucocytes</subject><subject>Leukocytes - physiology</subject><subject>Pentosephosphates - metabolism</subject><subject>Phagocytosis</subject><issn>0036-5513</issn><issn>1502-7686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOj5-gAshKx9g9SZ9JEU3MviCAUF0HdL0xqmkjSYtMv_eDjMIIrgKl_OdQ_gIOWRwwUDCJUBa5DmTDEooOeSwQSYsB56IQhabZLLMkxFId8hujO8w3qnMtsl2IUoBaTYhzy9zpGgtmp56Sx_f7s_p3amuTs441V1NI4ahpb6j_ci9ucH4iLTFXlfeNbGlTUfnQ6s76nDMzKLHuE-2rHYRD9bvHnm9u32ZPiSzp_vH6c0sMbyQfYKCZRprCTKvLLMVYGlLRDQZ49LUNQfOs7pKoSxLabUALqRmYJisCxCcp3vkeLX7EfzngLFXbRMNOqc79ENUIpWMZVyMIFuBJvgYA1r1EZpWh4VioJYe1R-PY-doPT5ULdY_jbW4Mb9e5U1nfWj1lw-uVr1eOB9s0J1pokr_m7_6VZ-jdv3c6IDq3Q-hG73987lv3G-QiQ</recordid><startdate>198105</startdate><enddate>198105</enddate><creator>Kjøsen, Berit</creator><creator>Bassøe, Hans H.</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198105</creationdate><title>The effect of IgG, F(ab')2 and serum on the glucose metabolism in human leucocytes</title><author>Kjøsen, Berit ; Bassøe, Hans H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-e714aed8085bf1fb0e9f9eeec4128cdd20224db309998fa70278a10c18d607223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Blood</topic><topic>Carbon Dioxide - metabolism</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Immunoglobulin Fab Fragments</topic><topic>immunoglobulin G</topic><topic>Immunoglobulin G - physiology</topic><topic>In Vitro Techniques</topic><topic>Lactates - metabolism</topic><topic>Lactic Acid</topic><topic>leucocytes</topic><topic>Leukocytes - physiology</topic><topic>Pentosephosphates - metabolism</topic><topic>Phagocytosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kjøsen, Berit</creatorcontrib><creatorcontrib>Bassøe, Hans H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kjøsen, Berit</au><au>Bassøe, Hans H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of IgG, F(ab')2 and serum on the glucose metabolism in human leucocytes</atitle><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle><addtitle>Scand J Clin Lab Invest</addtitle><date>1981-05</date><risdate>1981</risdate><volume>41</volume><issue>3</issue><spage>311</spage><epage>318</epage><pages>311-318</pages><issn>0036-5513</issn><eissn>1502-7686</eissn><abstract>The glucose metabolism in human leucocytes was strongly stimulated by IgG, independent of whether phagocytosis occurred or not. The percentage increase was highest in the pentose phosphate pathway. Maximum stimulation of the glucose oxidation occurred with an IgG concentration of 1-4 g/l. The insignificant effect of F(ab')2 fragments indicated that the Fc piece is necessary for the stimulation by IgG. In nonphagocytosing leucocytes, serum stimulated the lactate production more and the CO2 production less than indicated by the IgG content of the serum. During phagocytosis or with high IgG concentrations, serum increased the glucose oxidation to a greater extent than did IgG alone. These results indicate that IgG is one of the components in serum most important for the stimulation of glucose oxidation in leucocytes. Serum factors counteracting the stimulation of glucose oxidation by IgG in nonphagocytosing leucocytes may have a regulating effect in vivo.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>6797034</pmid><doi>10.1080/00365518109092050</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0036-5513 |
| ispartof | Scandinavian journal of clinical and laboratory investigation, 1981-05, Vol.41 (3), p.311-318 |
| issn | 0036-5513 1502-7686 |
| language | eng |
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| source | MEDLINE; Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | Blood Carbon Dioxide - metabolism Glucose - metabolism Humans Immunoglobulin Fab Fragments immunoglobulin G Immunoglobulin G - physiology In Vitro Techniques Lactates - metabolism Lactic Acid leucocytes Leukocytes - physiology Pentosephosphates - metabolism Phagocytosis |
| title | The effect of IgG, F(ab')2 and serum on the glucose metabolism in human leucocytes |
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