HEMATOLOGICAL ALTERATIONS IN TUMOR-BEARING RATS, WITH REFERENCE TO PATHOGENESIS OF CHRONIC TYPE OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME
Hematological studies were carried out serially in the rats transplanted subcutaneously with Yoshida ascites hepatoma AH-109A. Significant changes were observed in fibrinogen level, fibrinogen degradation products, recalcification time, platelet count, and fragmentation of red blood cells. Formation...
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| Veröffentlicht in: | GANN Japanese Journal of Cancer Research 1977/12/31, Vol.68(6), pp.797-804 |
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| container_title | GANN Japanese Journal of Cancer Research |
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| creator | KHATO, Juneji SATO, Toshio SATO, Haruo ABE, Kazuo ENDO, Eiko OHTA, Eiko FUKUOKA, Yoshio |
| description | Hematological studies were carried out serially in the rats transplanted subcutaneously with Yoshida ascites hepatoma AH-109A. Significant changes were observed in fibrinogen level, fibrinogen degradation products, recalcification time, platelet count, and fragmentation of red blood cells. Formation of thrombi was revealed in the vessels of tumor tissue morphologically from early stage when the tumor grew to a palpable size. Thrombi were formed also in the arterioles of the lungs in the terminal stage. Bleeding tendency was noted in some cases at death. These findings suggested the experimental induction of a type of disseminated intravascular coagulation. The systemic changes of the blood occurring in the terminal stage were preceded by localized intravascular coagulation and fibrinolysis in the tumor in early stage of tumor growth. |
| doi_str_mv | 10.20772/cancersci1959.68.6_797 |
| format | Article |
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Significant changes were observed in fibrinogen level, fibrinogen degradation products, recalcification time, platelet count, and fragmentation of red blood cells. Formation of thrombi was revealed in the vessels of tumor tissue morphologically from early stage when the tumor grew to a palpable size. Thrombi were formed also in the arterioles of the lungs in the terminal stage. Bleeding tendency was noted in some cases at death. These findings suggested the experimental induction of a type of disseminated intravascular coagulation. The systemic changes of the blood occurring in the terminal stage were preceded by localized intravascular coagulation and fibrinolysis in the tumor in early stage of tumor growth.</description><identifier>ISSN: 0016-450X</identifier><identifier>DOI: 10.20772/cancersci1959.68.6_797</identifier><identifier>PMID: 202534</identifier><language>eng</language><publisher>Japan: The Japanese Cancer Association</publisher><subject>Animals ; Blood Cell Count ; Blood Coagulation ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - pathology ; Disseminated intravascular coagulation ; Disseminated Intravascular Coagulation - etiology ; Fibrin Fibrinogen Degradation Products - analysis ; Fibrinogen - analysis ; Hematocrit ; Hepatoma ; Liver Neoplasms ; Male ; Neoplasms, Experimental - blood ; Neoplasms, Experimental - pathology ; Rat ; Rats ; Serum Albumin - analysis ; Tumor-host relationship</subject><ispartof>GANN Japanese Journal of Cancer Research, 1977/12/31, Vol.68(6), pp.797-804</ispartof><rights>The Japanese Cancer Association</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/202534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KHATO, Juneji</creatorcontrib><creatorcontrib>SATO, Toshio</creatorcontrib><creatorcontrib>SATO, Haruo</creatorcontrib><creatorcontrib>ABE, Kazuo</creatorcontrib><creatorcontrib>ENDO, Eiko</creatorcontrib><creatorcontrib>OHTA, Eiko</creatorcontrib><creatorcontrib>FUKUOKA, Yoshio</creatorcontrib><title>HEMATOLOGICAL ALTERATIONS IN TUMOR-BEARING RATS, WITH REFERENCE TO PATHOGENESIS OF CHRONIC TYPE OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME</title><title>GANN Japanese Journal of Cancer Research</title><addtitle>GANN Japanese Journal of Cancer Research</addtitle><description>Hematological studies were carried out serially in the rats transplanted subcutaneously with Yoshida ascites hepatoma AH-109A. Significant changes were observed in fibrinogen level, fibrinogen degradation products, recalcification time, platelet count, and fragmentation of red blood cells. Formation of thrombi was revealed in the vessels of tumor tissue morphologically from early stage when the tumor grew to a palpable size. Thrombi were formed also in the arterioles of the lungs in the terminal stage. Bleeding tendency was noted in some cases at death. These findings suggested the experimental induction of a type of disseminated intravascular coagulation. The systemic changes of the blood occurring in the terminal stage were preceded by localized intravascular coagulation and fibrinolysis in the tumor in early stage of tumor growth.</description><subject>Animals</subject><subject>Blood Cell Count</subject><subject>Blood Coagulation</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Disseminated intravascular coagulation</subject><subject>Disseminated Intravascular Coagulation - etiology</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Fibrinogen - analysis</subject><subject>Hematocrit</subject><subject>Hepatoma</subject><subject>Liver Neoplasms</subject><subject>Male</subject><subject>Neoplasms, Experimental - blood</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Rat</subject><subject>Rats</subject><subject>Serum Albumin - analysis</subject><subject>Tumor-host relationship</subject><issn>0016-450X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc2O0zAQx33ga7XsGyDhEydSnEljx0eTuo2lNl45LrAny-s40KrtLkl74DV4YlK1AjGH-dDvr5nRDELvUzIBwhh8Cv4QYj-ETcpzPqHFhDrG2Qt0Q0hKk2lOvr1Bd8OwJaNRYMDoa_QKCOTZ9Ab9ruRKWL3UC1WKJRZLK42wStcNVjW265U2yWcpjKoXeATNR_xV2QobOZdG1qXEVuN7YSu9kLVsVIP1HJeV0bUqsX24l-d6pppGrlQtrJyNXa0RX0RTrpfC4FKLxZicB-LmoZ4ZvZJv0cvO74Z4d423aD2XtqyS65LJFnI4JjRCyCB2fJo_FiQnLaThnBHwtGCccp6OOBRFlrXQdbQNU-h4bAlQX2Rpm92iD5e-z_3Tz1Mcjm6_GULc7fwhPp0Gx7KCMOAwCt9dhafHfWzdc7_Z-_6Xu9xwxOqCt8PRf49_se-Pm7CL7r__OFo4enHjk_5pfvjexUP2B7rEg_o</recordid><startdate>197712</startdate><enddate>197712</enddate><creator>KHATO, Juneji</creator><creator>SATO, Toshio</creator><creator>SATO, Haruo</creator><creator>ABE, Kazuo</creator><creator>ENDO, Eiko</creator><creator>OHTA, Eiko</creator><creator>FUKUOKA, Yoshio</creator><general>The Japanese Cancer Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197712</creationdate><title>HEMATOLOGICAL ALTERATIONS IN TUMOR-BEARING RATS, WITH REFERENCE TO PATHOGENESIS OF CHRONIC TYPE OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME</title><author>KHATO, Juneji ; SATO, Toshio ; SATO, Haruo ; ABE, Kazuo ; ENDO, Eiko ; OHTA, Eiko ; FUKUOKA, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j252t-6e2c32ef945b8050d21c5b8002a6879699132ec8833d2ff6dc42f9ed026a831d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Blood Cell Count</topic><topic>Blood Coagulation</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Disseminated intravascular coagulation</topic><topic>Disseminated Intravascular Coagulation - etiology</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Fibrinogen - analysis</topic><topic>Hematocrit</topic><topic>Hepatoma</topic><topic>Liver Neoplasms</topic><topic>Male</topic><topic>Neoplasms, Experimental - blood</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Rat</topic><topic>Rats</topic><topic>Serum Albumin - analysis</topic><topic>Tumor-host relationship</topic><toplevel>online_resources</toplevel><creatorcontrib>KHATO, Juneji</creatorcontrib><creatorcontrib>SATO, Toshio</creatorcontrib><creatorcontrib>SATO, Haruo</creatorcontrib><creatorcontrib>ABE, Kazuo</creatorcontrib><creatorcontrib>ENDO, Eiko</creatorcontrib><creatorcontrib>OHTA, Eiko</creatorcontrib><creatorcontrib>FUKUOKA, Yoshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>GANN Japanese Journal of Cancer Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KHATO, Juneji</au><au>SATO, Toshio</au><au>SATO, Haruo</au><au>ABE, Kazuo</au><au>ENDO, Eiko</au><au>OHTA, Eiko</au><au>FUKUOKA, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HEMATOLOGICAL ALTERATIONS IN TUMOR-BEARING RATS, WITH REFERENCE TO PATHOGENESIS OF CHRONIC TYPE OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME</atitle><jtitle>GANN Japanese Journal of Cancer Research</jtitle><addtitle>GANN Japanese Journal of Cancer Research</addtitle><date>1977-12</date><risdate>1977</risdate><volume>68</volume><issue>6</issue><spage>797</spage><epage>804</epage><pages>797-804</pages><issn>0016-450X</issn><abstract>Hematological studies were carried out serially in the rats transplanted subcutaneously with Yoshida ascites hepatoma AH-109A. Significant changes were observed in fibrinogen level, fibrinogen degradation products, recalcification time, platelet count, and fragmentation of red blood cells. Formation of thrombi was revealed in the vessels of tumor tissue morphologically from early stage when the tumor grew to a palpable size. Thrombi were formed also in the arterioles of the lungs in the terminal stage. Bleeding tendency was noted in some cases at death. These findings suggested the experimental induction of a type of disseminated intravascular coagulation. The systemic changes of the blood occurring in the terminal stage were preceded by localized intravascular coagulation and fibrinolysis in the tumor in early stage of tumor growth.</abstract><cop>Japan</cop><pub>The Japanese Cancer Association</pub><pmid>202534</pmid><doi>10.20772/cancersci1959.68.6_797</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | GANN Japanese Journal of Cancer Research, 1977/12/31, Vol.68(6), pp.797-804 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Blood Cell Count Blood Coagulation Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - pathology Disseminated intravascular coagulation Disseminated Intravascular Coagulation - etiology Fibrin Fibrinogen Degradation Products - analysis Fibrinogen - analysis Hematocrit Hepatoma Liver Neoplasms Male Neoplasms, Experimental - blood Neoplasms, Experimental - pathology Rat Rats Serum Albumin - analysis Tumor-host relationship |
| title | HEMATOLOGICAL ALTERATIONS IN TUMOR-BEARING RATS, WITH REFERENCE TO PATHOGENESIS OF CHRONIC TYPE OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME |
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