Intracapillary oxyhemoglobin saturation of malignant tumors in humans
The oxygenation of cancer tissue in humans has been assessed by measuring the intracapillary oxyhemoglobin saturations (i.c.HbO 2) in solid tumors of the oral cavity using a cryophotometric micrometbod. From histological investigations the tumors can be classified into three qualities of vasculariza...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1981-10, Vol.7 (10), p.1397-1404 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Mueller-Klieser, Wolfgang Vaupel, Peter Manz, Rolf Schmidseder, Ralf |
| description | The oxygenation of cancer tissue in humans has been assessed by measuring the intracapillary oxyhemoglobin saturations (i.c.HbO
2) in solid tumors of the oral cavity using a cryophotometric micrometbod. From histological investigations the tumors can be classified into three qualities of vascularization: (i) well vascularized tumors, (ii) tumors with medium quality of vascularization, and (iii) poorly vascularized tumors. In all three tumor types i.c.HbO
2 distribution curves are shifted to significantly lower values than saturation curves in normal oral mucosa. The extent of this shift can be related to the degree of the reduction in tumor vasculature. In addition, great regional inhomogeneities in i.c.HbO
2 values can be detected. Comparison of these results with earlier measurements in the DS-Carcinosarcoma of the rat reveals that i.c.HbO
2 values in implantation tumors of rats are considerably lower than saturations in tumors of the oral cavity in humans as involved in this study. The differences in tumor oxygenation can be explained by differences in growth stage, in the site of tumor growth, and in influences of the host on the tumor oxygenation. |
| doi_str_mv | 10.1016/0360-3016(81)90036-5 |
| format | Article |
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2) in solid tumors of the oral cavity using a cryophotometric micrometbod. From histological investigations the tumors can be classified into three qualities of vascularization: (i) well vascularized tumors, (ii) tumors with medium quality of vascularization, and (iii) poorly vascularized tumors. In all three tumor types i.c.HbO
2 distribution curves are shifted to significantly lower values than saturation curves in normal oral mucosa. The extent of this shift can be related to the degree of the reduction in tumor vasculature. In addition, great regional inhomogeneities in i.c.HbO
2 values can be detected. Comparison of these results with earlier measurements in the DS-Carcinosarcoma of the rat reveals that i.c.HbO
2 values in implantation tumors of rats are considerably lower than saturations in tumors of the oral cavity in humans as involved in this study. The differences in tumor oxygenation can be explained by differences in growth stage, in the site of tumor growth, and in influences of the host on the tumor oxygenation.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(81)90036-5</identifier><identifier>PMID: 7319864</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - pathology ; Cryophotometry ; Human tumors ; Humans ; Intracapillary oxyhemoglobin saturation ; Kidney Neoplasms - blood ; Microcirculation ; Middle Aged ; Mouth Neoplasms - blood ; Mouth Neoplasms - blood supply ; Mouth Neoplasms - pathology ; Oxygen - blood ; Oxyhemoglobins - metabolism ; Vasculature</subject><ispartof>International journal of radiation oncology, biology, physics, 1981-10, Vol.7 (10), p.1397-1404</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-34359d6250f54d36ca9a195ebd70adbf0592a3559587042e7b632a52e7dc2b5e3</citedby><cites>FETCH-LOGICAL-c357t-34359d6250f54d36ca9a195ebd70adbf0592a3559587042e7b632a52e7dc2b5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0360301681900365$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7319864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mueller-Klieser, Wolfgang</creatorcontrib><creatorcontrib>Vaupel, Peter</creatorcontrib><creatorcontrib>Manz, Rolf</creatorcontrib><creatorcontrib>Schmidseder, Ralf</creatorcontrib><title>Intracapillary oxyhemoglobin saturation of malignant tumors in humans</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>The oxygenation of cancer tissue in humans has been assessed by measuring the intracapillary oxyhemoglobin saturations (i.c.HbO
2) in solid tumors of the oral cavity using a cryophotometric micrometbod. From histological investigations the tumors can be classified into three qualities of vascularization: (i) well vascularized tumors, (ii) tumors with medium quality of vascularization, and (iii) poorly vascularized tumors. In all three tumor types i.c.HbO
2 distribution curves are shifted to significantly lower values than saturation curves in normal oral mucosa. The extent of this shift can be related to the degree of the reduction in tumor vasculature. In addition, great regional inhomogeneities in i.c.HbO
2 values can be detected. Comparison of these results with earlier measurements in the DS-Carcinosarcoma of the rat reveals that i.c.HbO
2 values in implantation tumors of rats are considerably lower than saturations in tumors of the oral cavity in humans as involved in this study. The differences in tumor oxygenation can be explained by differences in growth stage, in the site of tumor growth, and in influences of the host on the tumor oxygenation.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cryophotometry</subject><subject>Human tumors</subject><subject>Humans</subject><subject>Intracapillary oxyhemoglobin saturation</subject><subject>Kidney Neoplasms - blood</subject><subject>Microcirculation</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - blood</subject><subject>Mouth Neoplasms - blood supply</subject><subject>Mouth Neoplasms - pathology</subject><subject>Oxygen - blood</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Vasculature</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAYxoMoc06_gUJPoodq0jRJexFkTB0MvCh4C2mSbpE2mUkq7tububGjp_d9eZ733w-ASwTvEET0HmIKc5yymwrd1jCVOTkCY1SxOseEfByD8cFyCs5C-IQQIsTKERgxjOqKlmMwm9vohRRr03XCbzL3s1np3i071xibBREHL6JxNnNt1ovOLK2wMYtD73zIkmM19MKGc3DSii7oi32cgPen2dv0JV-8Ps-nj4tcYsJijktMakULAltSKkylqAWqiW4Ug0I1LSR1IdLpNakYLAvNGooLQVKiZNEQjSfgejd37d3XoEPkvQlSp9OtdkPgDFeQkoomY7kzSu9C8Lrla2_69CBHkG_p8S0avkXDK8T_6HGS2q7284em1-rQtMeV9IedrtOT30Z7HqTRVmplvJaRK2f-X_AL2bB-wQ</recordid><startdate>198110</startdate><enddate>198110</enddate><creator>Mueller-Klieser, Wolfgang</creator><creator>Vaupel, Peter</creator><creator>Manz, Rolf</creator><creator>Schmidseder, Ralf</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198110</creationdate><title>Intracapillary oxyhemoglobin saturation of malignant tumors in humans</title><author>Mueller-Klieser, Wolfgang ; Vaupel, Peter ; Manz, Rolf ; Schmidseder, Ralf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-34359d6250f54d36ca9a195ebd70adbf0592a3559587042e7b632a52e7dc2b5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cryophotometry</topic><topic>Human tumors</topic><topic>Humans</topic><topic>Intracapillary oxyhemoglobin saturation</topic><topic>Kidney Neoplasms - blood</topic><topic>Microcirculation</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - blood</topic><topic>Mouth Neoplasms - blood supply</topic><topic>Mouth Neoplasms - pathology</topic><topic>Oxygen - blood</topic><topic>Oxyhemoglobins - metabolism</topic><topic>Vasculature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mueller-Klieser, Wolfgang</creatorcontrib><creatorcontrib>Vaupel, Peter</creatorcontrib><creatorcontrib>Manz, Rolf</creatorcontrib><creatorcontrib>Schmidseder, Ralf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mueller-Klieser, Wolfgang</au><au>Vaupel, Peter</au><au>Manz, Rolf</au><au>Schmidseder, Ralf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracapillary oxyhemoglobin saturation of malignant tumors in humans</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1981-10</date><risdate>1981</risdate><volume>7</volume><issue>10</issue><spage>1397</spage><epage>1404</epage><pages>1397-1404</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>The oxygenation of cancer tissue in humans has been assessed by measuring the intracapillary oxyhemoglobin saturations (i.c.HbO
2) in solid tumors of the oral cavity using a cryophotometric micrometbod. From histological investigations the tumors can be classified into three qualities of vascularization: (i) well vascularized tumors, (ii) tumors with medium quality of vascularization, and (iii) poorly vascularized tumors. In all three tumor types i.c.HbO
2 distribution curves are shifted to significantly lower values than saturation curves in normal oral mucosa. The extent of this shift can be related to the degree of the reduction in tumor vasculature. In addition, great regional inhomogeneities in i.c.HbO
2 values can be detected. Comparison of these results with earlier measurements in the DS-Carcinosarcoma of the rat reveals that i.c.HbO
2 values in implantation tumors of rats are considerably lower than saturations in tumors of the oral cavity in humans as involved in this study. The differences in tumor oxygenation can be explained by differences in growth stage, in the site of tumor growth, and in influences of the host on the tumor oxygenation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7319864</pmid><doi>10.1016/0360-3016(81)90036-5</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 1981-10, Vol.7 (10), p.1397-1404 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - pathology Cryophotometry Human tumors Humans Intracapillary oxyhemoglobin saturation Kidney Neoplasms - blood Microcirculation Middle Aged Mouth Neoplasms - blood Mouth Neoplasms - blood supply Mouth Neoplasms - pathology Oxygen - blood Oxyhemoglobins - metabolism Vasculature |
| title | Intracapillary oxyhemoglobin saturation of malignant tumors in humans |
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