Superoxide production by rabbit pulmonary alveolar macrophages

Nitroblue tetrazolium (NBT) reduction by reduction by alveolar macrophages from normal and BCG-granulomatous rabbit lungs was inhibited by superoxide dismutase (SOD). Superoxide (.O 2 −) might therefore be involved, either direclty or indirectly, in the bactericidal activities of such cells. Cells f...

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Veröffentlicht in:	Life sciences (1973) 1977-12, Vol.21 (11), p.1575-1583
Hauptverfasser:	Lowrie, D.B., Aber, V.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriolysis Granuloma - metabolism Macrophages - physiology Nitroblue Tetrazolium Oxidation-Reduction Oxygen - metabolism Phagocytosis Pulmonary Alveoli - cytology Rabbits Superoxide Dismutase - metabolism Superoxides - metabolism
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Zusammenfassung:	Nitroblue tetrazolium (NBT) reduction by reduction by alveolar macrophages from normal and BCG-granulomatous rabbit lungs was inhibited by superoxide dismutase (SOD). Superoxide (.O 2 −) might therefore be involved, either direclty or indirectly, in the bactericidal activities of such cells. Cells from BCG-granulomatous rabbits did not, however, reduce significantly more NBT per cell than cells from normal rabbits.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(77)90234-X