A Comparison of Leukocyte Alkaline Phosphatase and Plasma Estradiol Measurements in the Monitoring of Clomiphene and Gonadotropin Therapy
Leukocyte alkaline phosphatase (LAP) and plasma estradiol (E2) were measured in 56 infertile women treated with clomiphene citrate and human chorionic gonadotropin (hCG) and in 21 infertile women treated with human menopausal gonadotropin (hMG) and hCG. Plasma LAP scores were found to correlate sign...
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| Veröffentlicht in: | Fertility and sterility 1977-12, Vol.28 (12), p.1371-1374 |
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| container_issue | 12 |
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| container_title | Fertility and sterility |
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| creator | Khanna, Indira McGarrigle, Hugh H.G. Radwanska, Ewa Swyer, Gerald I.M. |
| description | Leukocyte alkaline phosphatase (LAP) and plasma estradiol (E2) were measured in 56 infertile women treated with clomiphene citrate and human chorionic gonadotropin (hCG) and in 21 infertile women treated with human menopausal gonadotropin (hMG) and hCG.
Plasma LAP scores were found to correlate significantly with plasma E2 levels in both clomiphene- and hMG-stimulated patients, reflecting the dependence of LAP on the level of circulating plasma estrogens. However, the plasma LAP score failed to distinguish the difference between normal stimulated and hyperstimulated cycles following hMG administration. We conclude that plasma LAP measurements have little value in monitoring ovulation induction therapy. |
| doi_str_mv | 10.1016/S0015-0282(16)42987-0 |
| format | Article |
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Plasma LAP scores were found to correlate significantly with plasma E2 levels in both clomiphene- and hMG-stimulated patients, reflecting the dependence of LAP on the level of circulating plasma estrogens. However, the plasma LAP score failed to distinguish the difference between normal stimulated and hyperstimulated cycles following hMG administration. We conclude that plasma LAP measurements have little value in monitoring ovulation induction therapy.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)42987-0</identifier><identifier>PMID: 590548</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Alkaline Phosphatase - blood ; Chorionic Gonadotropin - therapeutic use ; Clomiphene - therapeutic use ; Estradiol - blood ; Female ; Humans ; Infertility, Female - blood ; Infertility, Female - drug therapy ; Infertility, Female - enzymology ; Leukocytes - enzymology</subject><ispartof>Fertility and sterility, 1977-12, Vol.28 (12), p.1371-1374</ispartof><rights>1977 American Society for Reproductive Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-1f3d603ee47be8a3f468772d8a9e2c919de037d8b5e9585192bd06a12a1396bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)42987-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/590548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khanna, Indira</creatorcontrib><creatorcontrib>McGarrigle, Hugh H.G.</creatorcontrib><creatorcontrib>Radwanska, Ewa</creatorcontrib><creatorcontrib>Swyer, Gerald I.M.</creatorcontrib><title>A Comparison of Leukocyte Alkaline Phosphatase and Plasma Estradiol Measurements in the Monitoring of Clomiphene and Gonadotropin Therapy</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Leukocyte alkaline phosphatase (LAP) and plasma estradiol (E2) were measured in 56 infertile women treated with clomiphene citrate and human chorionic gonadotropin (hCG) and in 21 infertile women treated with human menopausal gonadotropin (hMG) and hCG.
Plasma LAP scores were found to correlate significantly with plasma E2 levels in both clomiphene- and hMG-stimulated patients, reflecting the dependence of LAP on the level of circulating plasma estrogens. However, the plasma LAP score failed to distinguish the difference between normal stimulated and hyperstimulated cycles following hMG administration. We conclude that plasma LAP measurements have little value in monitoring ovulation induction therapy.</description><subject>Adult</subject><subject>Alkaline Phosphatase - blood</subject><subject>Chorionic Gonadotropin - therapeutic use</subject><subject>Clomiphene - therapeutic use</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - drug therapy</subject><subject>Infertility, Female - enzymology</subject><subject>Leukocytes - enzymology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRAFhsIfgORVRRcpfsSOs0KjUVuQpqISZW058Q0xTexgO5XmE_hrMk3VLaurq3seuucg9JGSC0qo_PyDECoKwhT7ROV5yWpVFeQF2lAhZCGk4C_R5hnyBr1N6TchRNKKvUavRE1EqTbo7xbvwjiZ6FLwOHR4D_N9aA8Z8Ha4N4PzgG_7kKbeZJMAG2_x7WDSaPBlytFYFwZ8AybNEUbwOWHnce4B3wTvcojO_zqq7oYwuqkHvypcB29syDFMC_quh2imwzt00pkhwfuneYp-Xl3e7b4W--_X33bbfdFyUeaCdtxKwgHKqgFleFdKVVXMKlMDa2taWyC8sqoRUAslaM0aS6ShzFBey6bhp-hs1Z1i-DNDynp0qYVhMB7CnHTFK1VKphagWIFtDClF6PQU3WjiQVOijw3oxwb0MV69bI8NaLLwPjwZzM0I9pm1Rr6cv6xnWJ58cBB1ah34FqyL0GZtg_uPwT99cped</recordid><startdate>197712</startdate><enddate>197712</enddate><creator>Khanna, Indira</creator><creator>McGarrigle, Hugh H.G.</creator><creator>Radwanska, Ewa</creator><creator>Swyer, Gerald I.M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197712</creationdate><title>A Comparison of Leukocyte Alkaline Phosphatase and Plasma Estradiol Measurements in the Monitoring of Clomiphene and Gonadotropin Therapy</title><author>Khanna, Indira ; McGarrigle, Hugh H.G. ; Radwanska, Ewa ; Swyer, Gerald I.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-1f3d603ee47be8a3f468772d8a9e2c919de037d8b5e9585192bd06a12a1396bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - blood</topic><topic>Chorionic Gonadotropin - therapeutic use</topic><topic>Clomiphene - therapeutic use</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Infertility, Female - blood</topic><topic>Infertility, Female - drug therapy</topic><topic>Infertility, Female - enzymology</topic><topic>Leukocytes - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khanna, Indira</creatorcontrib><creatorcontrib>McGarrigle, Hugh H.G.</creatorcontrib><creatorcontrib>Radwanska, Ewa</creatorcontrib><creatorcontrib>Swyer, Gerald I.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khanna, Indira</au><au>McGarrigle, Hugh H.G.</au><au>Radwanska, Ewa</au><au>Swyer, Gerald I.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Leukocyte Alkaline Phosphatase and Plasma Estradiol Measurements in the Monitoring of Clomiphene and Gonadotropin Therapy</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1977-12</date><risdate>1977</risdate><volume>28</volume><issue>12</issue><spage>1371</spage><epage>1374</epage><pages>1371-1374</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>Leukocyte alkaline phosphatase (LAP) and plasma estradiol (E2) were measured in 56 infertile women treated with clomiphene citrate and human chorionic gonadotropin (hCG) and in 21 infertile women treated with human menopausal gonadotropin (hMG) and hCG.
Plasma LAP scores were found to correlate significantly with plasma E2 levels in both clomiphene- and hMG-stimulated patients, reflecting the dependence of LAP on the level of circulating plasma estrogens. However, the plasma LAP score failed to distinguish the difference between normal stimulated and hyperstimulated cycles following hMG administration. We conclude that plasma LAP measurements have little value in monitoring ovulation induction therapy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>590548</pmid><doi>10.1016/S0015-0282(16)42987-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 1977-12, Vol.28 (12), p.1371-1374 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73784628 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Alkaline Phosphatase - blood Chorionic Gonadotropin - therapeutic use Clomiphene - therapeutic use Estradiol - blood Female Humans Infertility, Female - blood Infertility, Female - drug therapy Infertility, Female - enzymology Leukocytes - enzymology |
| title | A Comparison of Leukocyte Alkaline Phosphatase and Plasma Estradiol Measurements in the Monitoring of Clomiphene and Gonadotropin Therapy |
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