Immunofluorescent studies of the development of pre‐B cells, B lymphocytes and immunoglobulin isotype diversity in humans

Immunofluorescent techniques were used to examine several aspects of B cell ontogeny in humans. Large lymphoid cells containing intracytoplasmic IgM (pre‐B cells) were present in fetal liver as early as 7 weeks of gestation, approximately 2 weeks prior to the appearance of surface IgM positive (sIgM...

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Veröffentlicht in:	European journal of immunology 1977-11, Vol.7 (11), p.804-810
Hauptverfasser:	Gathings, W.E., Lawton, A.R., Cooper, M.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Specificity B-Lymphocytes - growth & development Bone Marrow Cells Fetus Gestational Age Humans Immunoglobulin Fab Fragments Immunoglobulin Heavy Chains Liver - cytology Receptors, Antigen, B-Cell - analysis Spleen - cytology
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