Human fat cell adenylate cyclase. Modulation of parathyroid hormone action by guanine nucleotides

The effects of guanine nucleotides on basal and parathyroid hormone-stimulated adenylate cyclase of human fat cell ghosts were studied. GTP (10(-7)-10(-3) M) caused a dose-dependent inhibition of basal enzyme activity, but it had no significant effect on PTH-stimulated rates of cAMP-formation. The g...

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Veröffentlicht in:	Research in experimental medicine 1977-09, Vol.171 (2), p.201-204
Hauptverfasser:	Kather, H, Tschöpe, W, Simon, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Adipose Tissue - enzymology Cyclic AMP - metabolism Epinephrine - pharmacology Guanine Nucleotides - pharmacology Guanosine Monophosphate - metabolism Guanosine Triphosphate - metabolism Humans In Vitro Techniques Parathyroid Hormone - pharmacology Phosphorus Radioisotopes
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