α-difluoromethylornithine as a postcoitally effective antifertility agent in female rats

Intraperitoneal injection of α-difluoromethyl-ornithine (DFMO) at a dose of 200 mg/kg, twice a day, during days 4–7 of pregnancy caused inhibition of embryogenesis in rats. These animals did not deliver any pups at term. However, there was no effect of DFMO on pregnant rats following treatment durin...

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Veröffentlicht in:	Contraception (Stoneham) 1981-08, Vol.24 (2), p.215-221
Hauptverfasser:	Reddy, P.R.K., Rukmini, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Contraceptives, Postcoital - pharmacology Contraceptives, Postcoital, Synthetic - pharmacology Eflornithine Embryo Implantation Embryo, Mammalian - drug effects Female Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - metabolism Litter Size Ornithine - analogs & derivatives Ornithine - pharmacology Ornithine Decarboxylase - metabolism Pregnancy Rabbits Uterus - drug effects Uterus - enzymology
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