Vitamin D therapy in hypoparathyroidism and pseudohypoparathyroidism: Weight-related dosages for initiation of therapy and maintenance therapy
The aims of this study were to determine the dose of vitamin D 2 that maintains the serum calcium level within the normal range in hypoparathyroid and pseudohypoparathyroid children and to establish a safe and quickly acting dose for initiating therapy in symptomatic patients. The dose requirement f...
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| Veröffentlicht in: | The Journal of pediatrics 1977-12, Vol.91 (6), p.1006-1010 |
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| container_title | The Journal of pediatrics |
| container_volume | 91 |
| creator | Kind, Hans Peter Handysides, Alan Kooh, Sang Whay Fraser, Donald |
| description | The aims of this study were to determine the dose of vitamin D
2 that maintains the serum calcium level within the normal range in hypoparathyroid and pseudohypoparathyroid children and to establish a safe and quickly acting dose for initiating therapy in symptomatic patients. The dose requirement for maintenance therapy was studied in 11 patients and initiation therapy was studied in five newly diagnosed hypocalcemic patients. The results show that (1) the maintenance requirement of vitamin D
2 is proportional to body weight and averages 2,000 IU (50 μg)/kg/day for children of all ages and with all types of hypoparathyroid disorders and that (2) in newly diagnosed symptomatic patients, carefully controlled administration of 8,000 IU (200 μg) vitamin D
2/kg/day for the first one to two weeks corrects hypocalcemia quickly and safely. |
| doi_str_mv | 10.1016/S0022-3476(77)80917-7 |
| format | Article |
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2 that maintains the serum calcium level within the normal range in hypoparathyroid and pseudohypoparathyroid children and to establish a safe and quickly acting dose for initiating therapy in symptomatic patients. The dose requirement for maintenance therapy was studied in 11 patients and initiation therapy was studied in five newly diagnosed hypocalcemic patients. The results show that (1) the maintenance requirement of vitamin D
2 is proportional to body weight and averages 2,000 IU (50 μg)/kg/day for children of all ages and with all types of hypoparathyroid disorders and that (2) in newly diagnosed symptomatic patients, carefully controlled administration of 8,000 IU (200 μg) vitamin D
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2 that maintains the serum calcium level within the normal range in hypoparathyroid and pseudohypoparathyroid children and to establish a safe and quickly acting dose for initiating therapy in symptomatic patients. The dose requirement for maintenance therapy was studied in 11 patients and initiation therapy was studied in five newly diagnosed hypocalcemic patients. The results show that (1) the maintenance requirement of vitamin D
2 is proportional to body weight and averages 2,000 IU (50 μg)/kg/day for children of all ages and with all types of hypoparathyroid disorders and that (2) in newly diagnosed symptomatic patients, carefully controlled administration of 8,000 IU (200 μg) vitamin D
2/kg/day for the first one to two weeks corrects hypocalcemia quickly and safely.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Body Weight</subject><subject>Calcium - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Administration Schedule</subject><subject>Ergocalciferols - administration & dosage</subject><subject>Ergocalciferols - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Hypocalcemia - drug therapy</subject><subject>Hypoparathyroidism - blood</subject><subject>Hypoparathyroidism - drug therapy</subject><subject>Male</subject><subject>Pseudohypoparathyroidism - blood</subject><subject>Pseudohypoparathyroidism - drug therapy</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - therapeutic use</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFO3DAUtBAFtgt_AJJPFT2EvsRJHPdSVbQFJKQe2sLRemu_sEabONhepP0JvrlZFvbCgZP1PPNm9GYYO8nhLIe8_vIHoCgyUcr6VMrPDahcZnKHTXJQMqsbIXbZZEs5YB9jvAcAVQLssz0BolblhD3duISd6_kPnuYUcFjxcZivBj9gwDRfBe-six3H3vIh0tL6t-BXfkvubp6yQAtMZLn1Ee8o8taHUc4lh8n5nvt2a7KW69D1iXrsDb3-H7IPLS4iHb28U_bv18-_55fZ9e-Lq_Pv15kRlUrjRaLCvBHG1EKa1igBZKBFamYSKzWDolI1WShEQTXNrBFFjU0plCmhVVUppuzTRncI_mFJMenORUOLBfbkl1FLIStoynwkVhuiCT7GQK0eguswrHQOel2Dfq5BrzPWUurnGsb1KTt-MVjOOrLbrU3uI_xtA9N45KOjoKNxNAZhXSCTtPXuHYP_2gubeg</recordid><startdate>197712</startdate><enddate>197712</enddate><creator>Kind, Hans Peter</creator><creator>Handysides, Alan</creator><creator>Kooh, Sang Whay</creator><creator>Fraser, Donald</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197712</creationdate><title>Vitamin D therapy in hypoparathyroidism and pseudohypoparathyroidism: Weight-related dosages for initiation of therapy and maintenance therapy</title><author>Kind, Hans Peter ; Handysides, Alan ; Kooh, Sang Whay ; Fraser, Donald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-3435a183cc637cfc930ec0fae8b7a59b02596ed0232e6ebdc326a8439c40f9543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Body Weight</topic><topic>Calcium - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Administration Schedule</topic><topic>Ergocalciferols - administration & dosage</topic><topic>Ergocalciferols - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Hypocalcemia - drug therapy</topic><topic>Hypoparathyroidism - blood</topic><topic>Hypoparathyroidism - drug therapy</topic><topic>Male</topic><topic>Pseudohypoparathyroidism - blood</topic><topic>Pseudohypoparathyroidism - drug therapy</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kind, Hans Peter</creatorcontrib><creatorcontrib>Handysides, Alan</creatorcontrib><creatorcontrib>Kooh, Sang Whay</creatorcontrib><creatorcontrib>Fraser, Donald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kind, Hans Peter</au><au>Handysides, Alan</au><au>Kooh, Sang Whay</au><au>Fraser, Donald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D therapy in hypoparathyroidism and pseudohypoparathyroidism: Weight-related dosages for initiation of therapy and maintenance therapy</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1977-12</date><risdate>1977</risdate><volume>91</volume><issue>6</issue><spage>1006</spage><epage>1010</epage><pages>1006-1010</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>The aims of this study were to determine the dose of vitamin D
2 that maintains the serum calcium level within the normal range in hypoparathyroid and pseudohypoparathyroid children and to establish a safe and quickly acting dose for initiating therapy in symptomatic patients. The dose requirement for maintenance therapy was studied in 11 patients and initiation therapy was studied in five newly diagnosed hypocalcemic patients. The results show that (1) the maintenance requirement of vitamin D
2 is proportional to body weight and averages 2,000 IU (50 μg)/kg/day for children of all ages and with all types of hypoparathyroid disorders and that (2) in newly diagnosed symptomatic patients, carefully controlled administration of 8,000 IU (200 μg) vitamin D
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| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1977-12, Vol.91 (6), p.1006-1010 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73750841 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adolescent Adult Body Weight Calcium - blood Child Child, Preschool Drug Administration Schedule Ergocalciferols - administration & dosage Ergocalciferols - therapeutic use Female Humans Hypocalcemia - drug therapy Hypoparathyroidism - blood Hypoparathyroidism - drug therapy Male Pseudohypoparathyroidism - blood Pseudohypoparathyroidism - drug therapy Vitamin D - administration & dosage Vitamin D - therapeutic use |
| title | Vitamin D therapy in hypoparathyroidism and pseudohypoparathyroidism: Weight-related dosages for initiation of therapy and maintenance therapy |
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