Human Blood Preservation: Effect on in Vitro Protein Binding

In vitro plasma protein binding for phenytoin, meperidine, and bretylium tosylate was affected by the type of preserved human blood used for its estimation. Fresh heparinized plasma and serum gave equivalent fractions bound at the concentrations studied for all three drugs. However, the in vitro pla...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1981-10, Vol.70 (10), p.1168-1169
Hauptverfasser:	Jackson, André J., Miller, Ann K., Narang, Prem K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Binding, plasma protein—effect of blood preservation, humans Blood Preservation Blood Proteins - metabolism Blood—preservation, effect on in vitro plasma protein binding Bretylium Tosylate - blood effect on in vitro plasma protein binding Freeze Drying Humans In Vitro Techniques Meperidine - blood Pharmacokinetics-effect of human blood preservation on in vitro protein binding Phenytoin - blood plasma protein-effect of blood preservation Protein Binding
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