The gonadotropin response of men with varicoceles to a four-hour infusion of gonadotropin-releasing hormone
The serum gonadotropin, testosterone, and estradiol responses to a 4-hour intravenous infusion of gonadotropin-releasing hormone (GnRH) were studied in four groups of men: severely oligospermic men with varicoceles and sperm densities less than 1×107/ml, men with varicoceles and sperm densities betw...
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| Veröffentlicht in: | Fertility and sterility 1981-11, Vol.36 (5), p.633-637 |
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| container_issue | 5 |
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| container_title | Fertility and sterility |
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| creator | Hudson, Robert W. Crawford, Vinton A. Mckay, David E. |
| description | The serum gonadotropin, testosterone, and estradiol responses to a 4-hour intravenous infusion of gonadotropin-releasing hormone (GnRH) were studied in four groups of men: severely oligospermic men with varicoceles and sperm densities less than 1×107/ml, men with varicoceles and sperm densities between 1.1×107 and 3×107/ml, men with varicoceles and sperm densities greater than 3×107/ml, and men of normal fertility. Each group had similar preinfusion luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels. Both the severely oligospermic men and the men with sperm densities between 1.1×107/ml and 3×107/ml had excessive gonadotropin responses to the GnRH infusion. The gonadotropin responses of the men with sperm densities greater than 3×107/ml were not different from normal. These results demonstrate that men with varicoceles and sperm densities less than 3×107/ml have an altered integrity of their hypothalamic-pituitary-testicular axes, which can be demonstrated by their responses to GnRH. |
| doi_str_mv | 10.1016/S0015-0282(16)45863-2 |
| format | Article |
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Each group had similar preinfusion luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels. Both the severely oligospermic men and the men with sperm densities between 1.1×107/ml and 3×107/ml had excessive gonadotropin responses to the GnRH infusion. The gonadotropin responses of the men with sperm densities greater than 3×107/ml were not different from normal. 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Each group had similar preinfusion luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels. Both the severely oligospermic men and the men with sperm densities between 1.1×107/ml and 3×107/ml had excessive gonadotropin responses to the GnRH infusion. The gonadotropin responses of the men with sperm densities greater than 3×107/ml were not different from normal. These results demonstrate that men with varicoceles and sperm densities less than 3×107/ml have an altered integrity of their hypothalamic-pituitary-testicular axes, which can be demonstrated by their responses to GnRH.</description><subject>Adult</subject><subject>Estradiol - blood</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - administration & dosage</subject><subject>Humans</subject><subject>Infusions, Parenteral</subject><subject>Injections, Intravenous</subject><subject>Kinetics</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Oligospermia - blood</subject><subject>Sperm Count</subject><subject>Testosterone - blood</subject><subject>Varicocele - blood</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQQC1UtF0on4DkU9Ue0tpjx05OCKEClZA4sD1bjjNh3W7sxU6o-Pt62RXi1ovH1ryZ8TxCzjn7xhlX3x8Y43XFoIEvXH2VdaNEBUdkyetaVbWqxQeyfEM-kpOcfzPGFNewIAulWyUlX5I_qzXSxxhsH6cUtz7QhHkbQ0YaBzpioH_9tKbPNnkXHW4w0ylSS4c4p2pdDurDMGcfw45_36hKhbbZh0e6jmmMAT-R48FuMp4d4in5df1jdXVb3d3f_Ly6vKucAICqa2oL0groeKdbyTvATgMvV0BU2LVMdu0waOkaEFIis1bqQQvomx7BCXFKPu_7blN8mjFPZvS5_H1jA8Y5Gy20bEG0Baz3oEsx54SD2SY_2vRiODM7yeZVstkZNOX1KtlAqTs_DJi7Efu3qoPVkr_Y57Fs-ewxmew8Boe9T-gm00f_nwn_AGM1jYs</recordid><startdate>198111</startdate><enddate>198111</enddate><creator>Hudson, Robert W.</creator><creator>Crawford, Vinton A.</creator><creator>Mckay, David E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198111</creationdate><title>The gonadotropin response of men with varicoceles to a four-hour infusion of gonadotropin-releasing hormone</title><author>Hudson, Robert W. ; Crawford, Vinton A. ; Mckay, David E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3222-b85a24a32b1b7941b2eb7217942ee6eb904b9ff74c82344e0aa47f732d8de2c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Estradiol - blood</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - administration & dosage</topic><topic>Humans</topic><topic>Infusions, Parenteral</topic><topic>Injections, Intravenous</topic><topic>Kinetics</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Oligospermia - blood</topic><topic>Sperm Count</topic><topic>Testosterone - blood</topic><topic>Varicocele - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hudson, Robert W.</creatorcontrib><creatorcontrib>Crawford, Vinton A.</creatorcontrib><creatorcontrib>Mckay, David E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hudson, Robert W.</au><au>Crawford, Vinton A.</au><au>Mckay, David E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The gonadotropin response of men with varicoceles to a four-hour infusion of gonadotropin-releasing hormone</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1981-11</date><risdate>1981</risdate><volume>36</volume><issue>5</issue><spage>633</spage><epage>637</epage><pages>633-637</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>The serum gonadotropin, testosterone, and estradiol responses to a 4-hour intravenous infusion of gonadotropin-releasing hormone (GnRH) were studied in four groups of men: severely oligospermic men with varicoceles and sperm densities less than 1×107/ml, men with varicoceles and sperm densities between 1.1×107 and 3×107/ml, men with varicoceles and sperm densities greater than 3×107/ml, and men of normal fertility. Each group had similar preinfusion luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels. Both the severely oligospermic men and the men with sperm densities between 1.1×107/ml and 3×107/ml had excessive gonadotropin responses to the GnRH infusion. The gonadotropin responses of the men with sperm densities greater than 3×107/ml were not different from normal. These results demonstrate that men with varicoceles and sperm densities less than 3×107/ml have an altered integrity of their hypothalamic-pituitary-testicular axes, which can be demonstrated by their responses to GnRH.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6796441</pmid><doi>10.1016/S0015-0282(16)45863-2</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1981-11, Vol.36 (5), p.633-637 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Estradiol - blood Follicle Stimulating Hormone - blood Gonadotropin-Releasing Hormone - administration & dosage Humans Infusions, Parenteral Injections, Intravenous Kinetics Luteinizing Hormone - blood Male Oligospermia - blood Sperm Count Testosterone - blood Varicocele - blood |
| title | The gonadotropin response of men with varicoceles to a four-hour infusion of gonadotropin-releasing hormone |
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