Serum iga and emotional expression in breast cancer patients
As part of a multidisciplinary study of 160 women admitted consecutively for breast tumour biopsy, we measured expression of anger and serum immunoglobulins before operation, when we had no knowledge of the provisional diagnosis, and at 3, 12 and 24 months after operation. Expression of anger was no...
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| Veröffentlicht in: | Journal of psychosomatic research 1977, Vol.21 (5), p.395-399 |
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| container_end_page | 399 |
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| container_title | Journal of psychosomatic research |
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| creator | Pettingale, Keith W. Greer, Steven Tee, Dudley E.H. |
| description | As part of a multidisciplinary study of 160 women admitted consecutively for breast tumour biopsy, we measured expression of anger and serum immunoglobulins before operation, when we had no knowledge of the provisional diagnosis, and at 3, 12 and 24 months after operation. Expression of anger was not related to serum IgG, IgM or IgE levels, but IgA levels were found to be significantly higher in patients who habitually suppressed anger than in those who were able to express anger (
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| doi_str_mv | 10.1016/0022-3999(77)90048-4 |
| format | Article |
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p<0·001). This correlation was found before operation both in cancer patients and those with benign breast disease. Over the subsequent two years serum IgA levels remained consistently higher in all patients who suppressed anger, but only reached statistical significance in breast cancer patients 3 months (
p<0·02) and 2 years (
p<0·03) following operation. We suggest how such an association might play a part in the pathogenesis of breast cancer.</description><identifier>ISSN: 0022-3999</identifier><identifier>EISSN: 1879-1360</identifier><identifier>DOI: 10.1016/0022-3999(77)90048-4</identifier><identifier>PMID: 592230</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Anger ; Breast Neoplasms - etiology ; Breast Neoplasms - immunology ; Breast Neoplasms - psychology ; Female ; Humans ; Immunoglobulin A - analysis ; Immunoglobulin E - analysis ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis</subject><ispartof>Journal of psychosomatic research, 1977, Vol.21 (5), p.395-399</ispartof><rights>1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b20a83cfef23b4e8b2e0b9b0673a061bbaf7e4896e856e02f61db0b43663e7a03</citedby><cites>FETCH-LOGICAL-c356t-b20a83cfef23b4e8b2e0b9b0673a061bbaf7e4896e856e02f61db0b43663e7a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-3999(77)90048-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/592230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pettingale, Keith W.</creatorcontrib><creatorcontrib>Greer, Steven</creatorcontrib><creatorcontrib>Tee, Dudley E.H.</creatorcontrib><title>Serum iga and emotional expression in breast cancer patients</title><title>Journal of psychosomatic research</title><addtitle>J Psychosom Res</addtitle><description>As part of a multidisciplinary study of 160 women admitted consecutively for breast tumour biopsy, we measured expression of anger and serum immunoglobulins before operation, when we had no knowledge of the provisional diagnosis, and at 3, 12 and 24 months after operation. Expression of anger was not related to serum IgG, IgM or IgE levels, but IgA levels were found to be significantly higher in patients who habitually suppressed anger than in those who were able to express anger (
p<0·001). This correlation was found before operation both in cancer patients and those with benign breast disease. Over the subsequent two years serum IgA levels remained consistently higher in all patients who suppressed anger, but only reached statistical significance in breast cancer patients 3 months (
p<0·02) and 2 years (
p<0·03) following operation. We suggest how such an association might play a part in the pathogenesis of breast cancer.</description><subject>Anger</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><issn>0022-3999</issn><issn>1879-1360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoN4G0ffYBZdiS6qp0maNCCCDN5gwIW6Dkl6KpHpxaQVfXs7dnDp6nD4L_B_hCwyuMggE5cAlKZMKXUm5bkC4EXKd8gsK6RKMyZgl8z-LIfkKMZ3ABCK5gdkP1eUMpiRq2cMQ534N5OYpkywbnvfNmad4FcXMMbxSXyT2IAm9okzjcOQdKb32PTxmOxVZh3xZHvn5PXu9mX5kK6e7h-XN6vUsVz0qaVgCuYqrCizHAtLEayyICQzIDJrTSWRF0pgkQsEWomstGA5E4KhNMDm5HTq7UL7MWDsde2jw_XaNNgOUUsmec4EG418MrrQxhiw0l3wtQnfOgO9YaY3QPQGiJZS_zLTfIwttv2DrbH8C02QRvl6knHc-Okx6OjG_Q5LH9D1umz9__0_EbF6tg</recordid><startdate>1977</startdate><enddate>1977</enddate><creator>Pettingale, Keith W.</creator><creator>Greer, Steven</creator><creator>Tee, Dudley E.H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1977</creationdate><title>Serum iga and emotional expression in breast cancer patients</title><author>Pettingale, Keith W. ; Greer, Steven ; Tee, Dudley E.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b20a83cfef23b4e8b2e0b9b0673a061bbaf7e4896e856e02f61db0b43663e7a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Anger</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - immunology</topic><topic>Breast Neoplasms - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pettingale, Keith W.</creatorcontrib><creatorcontrib>Greer, Steven</creatorcontrib><creatorcontrib>Tee, Dudley E.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychosomatic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pettingale, Keith W.</au><au>Greer, Steven</au><au>Tee, Dudley E.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum iga and emotional expression in breast cancer patients</atitle><jtitle>Journal of psychosomatic research</jtitle><addtitle>J Psychosom Res</addtitle><date>1977</date><risdate>1977</risdate><volume>21</volume><issue>5</issue><spage>395</spage><epage>399</epage><pages>395-399</pages><issn>0022-3999</issn><eissn>1879-1360</eissn><abstract>As part of a multidisciplinary study of 160 women admitted consecutively for breast tumour biopsy, we measured expression of anger and serum immunoglobulins before operation, when we had no knowledge of the provisional diagnosis, and at 3, 12 and 24 months after operation. Expression of anger was not related to serum IgG, IgM or IgE levels, but IgA levels were found to be significantly higher in patients who habitually suppressed anger than in those who were able to express anger (
p<0·001). This correlation was found before operation both in cancer patients and those with benign breast disease. Over the subsequent two years serum IgA levels remained consistently higher in all patients who suppressed anger, but only reached statistical significance in breast cancer patients 3 months (
p<0·02) and 2 years (
p<0·03) following operation. We suggest how such an association might play a part in the pathogenesis of breast cancer.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>592230</pmid><doi>10.1016/0022-3999(77)90048-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of psychosomatic research, 1977, Vol.21 (5), p.395-399 |
| issn | 0022-3999 1879-1360 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anger Breast Neoplasms - etiology Breast Neoplasms - immunology Breast Neoplasms - psychology Female Humans Immunoglobulin A - analysis Immunoglobulin E - analysis Immunoglobulin G - analysis Immunoglobulin M - analysis |
| title | Serum iga and emotional expression in breast cancer patients |
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