Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments

Presynaptic cholinergic mechanisms were investigated in various brain regions of aged Fisher 344 rats with documented 24 hr retention deficits measured in a single-trial passive avoidance task. Sodium-dependent high affinity choline uptake was found to be decreased by 22% in hippocampus of 23–26 mon...

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Veröffentlicht in:	Neurobiology of aging 1981-01, Vol.2 (2), p.99-104
Hauptverfasser:	Sherman, Kathleen A., Kuster, Joan E., Dean, Reginald L., Bartus, Raymond T., Friedman, Eitan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - biosynthesis Acetylcholine content Acetylcholine synthesis Aging Animals Brain - metabolism Brain Chemistry Choline - metabolism Choline acetyltransferase Choline O-Acetyltransferase - analysis Choline uptake Depolarization Hippocampus - metabolism Humans Memory Disorders - etiology Memory impairment Parasympathetic Nervous System - physiopathology Rats Rats, Inbred F344
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