The characterization of radioaerosol deposition in the healthy lung by histogram distribution analysis
Thirteen healthy nonsmoking volunteers inhaled an 8.1 micrometers (MMAD) radioaerosol on two occasions. Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during...
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| Veröffentlicht in: | Chest 1981-12, Vol.80 (6 Suppl), p.840-842 |
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| creator | Garrard, C S Gerrity, T R Schreiner, J F Yeates, D B |
| description | Thirteen healthy nonsmoking volunteers inhaled an 8.1 micrometers (MMAD) radioaerosol on two occasions. Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during the first ten minutes after aerosol inhalation. Deposition pattern was also expressed as the percentage of deposited activity retained within the lung at 24 hr (24 hr % retention) and found to be significantly correlated with measures of skew (P less than 0.001). Tests of pulmonary function (FEV1, FVC, and MMFR) were significantly correlated with skew. Correlations were also demonstrated for these pulmonary function tests with 24 hr % retention but at lower levels of significance. Results indicate that changes in measures of forced expiratory airflow in healthy human volunteers influence deposition pattern and that the skew of the distribution of inhaled radioactivity may provide an acceptable index of deposition pattern. |
| doi_str_mv | 10.1378/chest.80.6.840 |
| format | Article |
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Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during the first ten minutes after aerosol inhalation. Deposition pattern was also expressed as the percentage of deposited activity retained within the lung at 24 hr (24 hr % retention) and found to be significantly correlated with measures of skew (P less than 0.001). Tests of pulmonary function (FEV1, FVC, and MMFR) were significantly correlated with skew. Correlations were also demonstrated for these pulmonary function tests with 24 hr % retention but at lower levels of significance. Results indicate that changes in measures of forced expiratory airflow in healthy human volunteers influence deposition pattern and that the skew of the distribution of inhaled radioactivity may provide an acceptable index of deposition pattern.</description><identifier>ISSN: 0012-3692</identifier><identifier>DOI: 10.1378/chest.80.6.840</identifier><identifier>PMID: 7307622</identifier><language>eng</language><publisher>United States</publisher><subject>551001 - Physiological Systems- Tracer Techniques ; 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987) ; Adult ; AEROSOLS ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; BIOMEDICAL RADIOGRAPHY ; BODY ; CAMERAS ; COLLOIDS ; DIAGNOSTIC TECHNIQUES ; DISPERSIONS ; DYNAMIC FUNCTION STUDIES ; Female ; Forced Expiratory Volume ; GAMMA CAMERAS ; Humans ; INHALATION ; INTAKE ; Lung - metabolism ; LUNGS ; Male ; MAMMALS ; MAN ; Maximal Midexpiratory Flow Rate ; MEDICINE ; Middle Aged ; NUCLEAR MEDICINE ; ORGANS ; PRIMATES ; RADIATION, THERMAL, AND OTHER ENVIRON. 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MAT ; RADIOACTIVE AEROSOLS ; RADIOLOGY ; Respiration ; RESPIRATORY SYSTEM ; RETENTION ; SOLS ; Technetium ; VERTEBRATES ; Vital Capacity</subject><ispartof>Chest, 1981-12, Vol.80 (6 Suppl), p.840-842</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-542968b6425e4f5d97adc9e5df01cc5ee801ec477e551f4e0a48c35ce35210963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7307622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5462700$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Garrard, C S</creatorcontrib><creatorcontrib>Gerrity, T R</creatorcontrib><creatorcontrib>Schreiner, J F</creatorcontrib><creatorcontrib>Yeates, D B</creatorcontrib><creatorcontrib>Department of Medicine, Abraham Lincoln School of Medicine, University of Illinois at the Medical Center, Chicago</creatorcontrib><title>The characterization of radioaerosol deposition in the healthy lung by histogram distribution analysis</title><title>Chest</title><addtitle>Chest</addtitle><description>Thirteen healthy nonsmoking volunteers inhaled an 8.1 micrometers (MMAD) radioaerosol on two occasions. Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during the first ten minutes after aerosol inhalation. Deposition pattern was also expressed as the percentage of deposited activity retained within the lung at 24 hr (24 hr % retention) and found to be significantly correlated with measures of skew (P less than 0.001). Tests of pulmonary function (FEV1, FVC, and MMFR) were significantly correlated with skew. Correlations were also demonstrated for these pulmonary function tests with 24 hr % retention but at lower levels of significance. Results indicate that changes in measures of forced expiratory airflow in healthy human volunteers influence deposition pattern and that the skew of the distribution of inhaled radioactivity may provide an acceptable index of deposition pattern.</description><subject>551001 - Physiological Systems- Tracer Techniques</subject><subject>560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)</subject><subject>Adult</subject><subject>AEROSOLS</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>BODY</subject><subject>CAMERAS</subject><subject>COLLOIDS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISPERSIONS</subject><subject>DYNAMIC FUNCTION STUDIES</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>GAMMA CAMERAS</subject><subject>Humans</subject><subject>INHALATION</subject><subject>INTAKE</subject><subject>Lung - metabolism</subject><subject>LUNGS</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Maximal Midexpiratory Flow Rate</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>NUCLEAR MEDICINE</subject><subject>ORGANS</subject><subject>PRIMATES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOACTIVE AEROSOLS</subject><subject>RADIOLOGY</subject><subject>Respiration</subject><subject>RESPIRATORY SYSTEM</subject><subject>RETENTION</subject><subject>SOLS</subject><subject>Technetium</subject><subject>VERTEBRATES</subject><subject>Vital Capacity</subject><issn>0012-3692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAURj2ASimsbEgWA1uD305GVPGSKrGU2XKdm8YojYvtDOXXkz7EdO_VPd83HITuKCko1-WTayHloiSFKkpBLtCUEMrmXFXsCl2n9E3Gm1ZqgiaaE60Ym6Jm1QJ2rY3WZYj-12YfehwaHG3tg4UYUuhwDbuQ_PHle5zHSAu2y-0ed0O_wes9bn3KYRPtFtfjFv16ONK2t90--XSDLhvbJbg9zxn6en1ZLd7ny8-3j8Xzcu4EZXkuBatUuVaCSRCNrCtta1eBrBtCnZMAJaHghNYgJW0EECtKx6UDLhklleIz9HDqDSl7k5zP4FoX-h5cNlIopgkZoccTtIvhZxiVma1PDrrO9hCGZDTXgmt-aCtOoBs1pAiN2UW_tXFvKDEH4-Zo3JTEKDMaHwP35-ZhvYX6Hz_r5n9YsoD_</recordid><startdate>198112</startdate><enddate>198112</enddate><creator>Garrard, C S</creator><creator>Gerrity, T R</creator><creator>Schreiner, J F</creator><creator>Yeates, D B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198112</creationdate><title>The characterization of radioaerosol deposition in the healthy lung by histogram distribution analysis</title><author>Garrard, C S ; Gerrity, T R ; Schreiner, J F ; Yeates, D B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-542968b6425e4f5d97adc9e5df01cc5ee801ec477e551f4e0a48c35ce35210963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>551001 - Physiological Systems- Tracer Techniques</topic><topic>560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)</topic><topic>Adult</topic><topic>AEROSOLS</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>BODY</topic><topic>CAMERAS</topic><topic>COLLOIDS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISPERSIONS</topic><topic>DYNAMIC FUNCTION STUDIES</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>GAMMA CAMERAS</topic><topic>Humans</topic><topic>INHALATION</topic><topic>INTAKE</topic><topic>Lung - metabolism</topic><topic>LUNGS</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Maximal Midexpiratory Flow Rate</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>NUCLEAR MEDICINE</topic><topic>ORGANS</topic><topic>PRIMATES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOACTIVE AEROSOLS</topic><topic>RADIOLOGY</topic><topic>Respiration</topic><topic>RESPIRATORY SYSTEM</topic><topic>RETENTION</topic><topic>SOLS</topic><topic>Technetium</topic><topic>VERTEBRATES</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garrard, C S</creatorcontrib><creatorcontrib>Gerrity, T R</creatorcontrib><creatorcontrib>Schreiner, J F</creatorcontrib><creatorcontrib>Yeates, D B</creatorcontrib><creatorcontrib>Department of Medicine, Abraham Lincoln School of Medicine, University of Illinois at the Medical Center, Chicago</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garrard, C S</au><au>Gerrity, T R</au><au>Schreiner, J F</au><au>Yeates, D B</au><aucorp>Department of Medicine, Abraham Lincoln School of Medicine, University of Illinois at the Medical Center, Chicago</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The characterization of radioaerosol deposition in the healthy lung by histogram distribution analysis</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1981-12</date><risdate>1981</risdate><volume>80</volume><issue>6 Suppl</issue><spage>840</spage><epage>842</epage><pages>840-842</pages><issn>0012-3692</issn><abstract>Thirteen healthy nonsmoking volunteers inhaled an 8.1 micrometers (MMAD) radioaerosol on two occasions. Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during the first ten minutes after aerosol inhalation. Deposition pattern was also expressed as the percentage of deposited activity retained within the lung at 24 hr (24 hr % retention) and found to be significantly correlated with measures of skew (P less than 0.001). Tests of pulmonary function (FEV1, FVC, and MMFR) were significantly correlated with skew. Correlations were also demonstrated for these pulmonary function tests with 24 hr % retention but at lower levels of significance. Results indicate that changes in measures of forced expiratory airflow in healthy human volunteers influence deposition pattern and that the skew of the distribution of inhaled radioactivity may provide an acceptable index of deposition pattern.</abstract><cop>United States</cop><pmid>7307622</pmid><doi>10.1378/chest.80.6.840</doi><tpages>3</tpages></addata></record> |
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| subjects | 551001 - Physiological Systems- Tracer Techniques 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987) Adult AEROSOLS ANIMALS BASIC BIOLOGICAL SCIENCES BIOMEDICAL RADIOGRAPHY BODY CAMERAS COLLOIDS DIAGNOSTIC TECHNIQUES DISPERSIONS DYNAMIC FUNCTION STUDIES Female Forced Expiratory Volume GAMMA CAMERAS Humans INHALATION INTAKE Lung - metabolism LUNGS Male MAMMALS MAN Maximal Midexpiratory Flow Rate MEDICINE Middle Aged NUCLEAR MEDICINE ORGANS PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOACTIVE AEROSOLS RADIOLOGY Respiration RESPIRATORY SYSTEM RETENTION SOLS Technetium VERTEBRATES Vital Capacity |
| title | The characterization of radioaerosol deposition in the healthy lung by histogram distribution analysis |
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