UK-37,248, A novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity

UK-37,248, 4-[-2-(1H-imidazol-1-yl)ethoxy] benzoic acid hydrochloride, in a human platelet microsomal preparation of thromboxane (Tx) synthetase, potently inhibited TxB 2 production, IC 50 = 3×10 −9M. In contrast, prostaglandin (PG) endoperoxide synthesis from ram seminal vesicle microsomes was unaf...

Ausführliche Beschreibung