Suppression of acute and chronic inflammation by orally administered prostaglandins

Oral administration of a stable analog of prostaglandin E, (PGE1), 15‐(S)‐15‐methyl‐prostaglandin E1, can suppress both chronic adjuvant‐induced polyarthritis and acute immune complex‐induced vasculitis in a dose dependent manner. Histopathologic studies of tibiotarsal joints from rats with adjuvant...

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Veröffentlicht in:	Arthritis and rheumatism 1981-09, Vol.24 (9), p.1151-1158
Hauptverfasser:	Kunkel, Steven L., Ogawa, Hiroshi, Conran, Philip B., Ward, Peter A., Zurier, Robert B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alprostadil - analogs & derivatives Animals Arthritis - drug therapy Arthritis - pathology Arthritis, Experimental - drug therapy Dose-Response Relationship, Drug Immune Complex Diseases - complications Joints - pathology Leg Male Prostaglandins E, Synthetic - administration & dosage Prostaglandins E, Synthetic - therapeutic use Rats Rats, Inbred Lew Vasculitis - drug therapy Vasculitis - etiology Vasculitis - pathology
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