Inactivation by chloroquine of α-galactosidase in cultured human skin fibroblasts

When human skin fibroblasts are cultured in the presence of chloroquine or NH 4Cl there is a decrease in the intracellular level of lysosomal hydrolases and a concomitant increase in the extracellular activity as compared with cells grown in the absence of a base (cf [18]). In a medium with 25 μM ch...

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Veröffentlicht in:	Experimental cell research 1981-12, Vol.136 (2), p.327-333
Hauptverfasser:	De Groot, Philip G., Elferink, Ronald Oude, Hollemans, Marja, Strijland, Anneke, Westerveld, Andries, Khan, P.Meera, Tager, Joseph M.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Galactosidase - antagonists & inhibitors Ammonium Chloride - pharmacology Cells, Cultured Chloroquine - pharmacology Culture Media - analysis Cycloheximide - pharmacology Dose-Response Relationship, Drug Fibroblasts Galactosidases - antagonists & inhibitors Glucuronidase - metabolism Hexosaminidases - metabolism Humans
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