Effects of prenatal and neonatal nutritional deficiencies on the 2′,3′-cyclic nucleotide-3′-phosphohydrolase activity in the brain and spinal cord of rats
Studies were made of the effects of deficiencies of protein, vitamin A, and pantothenic acid in the maternal diet during gestation and lactation on the activity of 2′,3′-cyclic nucleotide-3′-phosphohydrolase, a myelin marker, in the brain and spinal cord of the progeny. Neonatal and combined prenata...
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| Veröffentlicht in: | Experimental neurology 1977-12, Vol.57 (3), p.659-665 |
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| container_title | Experimental neurology |
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| creator | Nakhasi, H.L. Sharma, Mukut Singh, Harfit |
| description | Studies were made of the effects of deficiencies of protein, vitamin A, and pantothenic acid in the maternal diet during gestation and lactation on the activity of 2′,3′-cyclic nucleotide-3′-phosphohydrolase, a myelin marker, in the brain and spinal cord of the progeny. Neonatal and combined prenatal and neonatal protein deficiencies were continued to 14 days of age. At 14 and 21 days of age there was a significant decrease in body, brain, and spinal cord weights. Brain phosphohydrolase activity was significantly decreased in protein- and vitamin A-deficient rats at 21 days of age. However, there was no change in spinal cord activity in any of the experimental manipulations at this age. Protein deficiency at 14 days resulted in a significant decrease in spinal cord and a slight decrease in brain phosphohydrolase activity. Comparison of the control values of phosphohydrolase activity in brain and spinal cord at these ages showed that the spinal cord has a higher activity than the brain. |
| doi_str_mv | 10.1016/0014-4886(77)90099-1 |
| format | Article |
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Neonatal and combined prenatal and neonatal protein deficiencies were continued to 14 days of age. At 14 and 21 days of age there was a significant decrease in body, brain, and spinal cord weights. Brain phosphohydrolase activity was significantly decreased in protein- and vitamin A-deficient rats at 21 days of age. However, there was no change in spinal cord activity in any of the experimental manipulations at this age. Protein deficiency at 14 days resulted in a significant decrease in spinal cord and a slight decrease in brain phosphohydrolase activity. 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Neonatal and combined prenatal and neonatal protein deficiencies were continued to 14 days of age. At 14 and 21 days of age there was a significant decrease in body, brain, and spinal cord weights. Brain phosphohydrolase activity was significantly decreased in protein- and vitamin A-deficient rats at 21 days of age. However, there was no change in spinal cord activity in any of the experimental manipulations at this age. Protein deficiency at 14 days resulted in a significant decrease in spinal cord and a slight decrease in brain phosphohydrolase activity. Comparison of the control values of phosphohydrolase activity in brain and spinal cord at these ages showed that the spinal cord has a higher activity than the brain.</description><subject>2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Body Weight</subject><subject>Brain - enzymology</subject><subject>Brain - pathology</subject><subject>Deficiency Diseases - enzymology</subject><subject>Female</subject><subject>Lactation</subject><subject>Maternal-Fetal Exchange</subject><subject>Myelin Sheath - enzymology</subject><subject>Organ Size</subject><subject>Pantothenic Acid - deficiency</subject><subject>Phosphoric Diester Hydrolases - metabolism</subject><subject>Pregnancy</subject><subject>Protein Deficiency - enzymology</subject><subject>Rats</subject><subject>Spinal Cord - enzymology</subject><subject>Spinal Cord - pathology</subject><subject>Vitamin A Deficiency - enzymology</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctOxCAUJcbXOPoHLlgZTaxCYUq7MTHGV2LiRteEwm0G0ykVGJPZ-Sl-g5_kl0inE5cuLnDhnHO55yJ0TMkFJbS4JITyjJdlcSrEWUVIVWV0C00oqUiWc0a20eQPso8OQngjCcRzsYd2c0I4FxP0dds0oGPArsG9h05F1WLVGdyBG5NuGb2NNmUtNtBYbaFLkRgdjnPA-c_n9zlLS6ZXurU6EXQLLloD2fq6n7uQYr4y3rUqAFY62g8bV9iOCrVX6TQUDb0dymjnzfAhr2I4RDuNagMcbfYper27fbl5yJ6e7x9vrp8yzWZFzJQg2nAqNMsLU9SCV1UBNWMVF3VNlGI8tcmKmRazGTfcaFYWRhHDyhKMKjWbopNRt_fufQkhyoUNGtpWJSeWQQomWLKuSkA-ArV3IXhoZO_tQvmVpEQOc5GD6XIwXQoh13ORNNGON_rLegHmjzQOIj1fjc-Qevyw4GVYGw3G-jQfaZz9X_8XNHSiYg</recordid><startdate>197712</startdate><enddate>197712</enddate><creator>Nakhasi, H.L.</creator><creator>Sharma, Mukut</creator><creator>Singh, Harfit</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197712</creationdate><title>Effects of prenatal and neonatal nutritional deficiencies on the 2′,3′-cyclic nucleotide-3′-phosphohydrolase activity in the brain and spinal cord of rats</title><author>Nakhasi, H.L. ; Sharma, Mukut ; Singh, Harfit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-a70cd417c326d6b74996eb33947bb0aa34fec365c7554d4dc386da0d388eda8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Body Weight</topic><topic>Brain - enzymology</topic><topic>Brain - pathology</topic><topic>Deficiency Diseases - enzymology</topic><topic>Female</topic><topic>Lactation</topic><topic>Maternal-Fetal Exchange</topic><topic>Myelin Sheath - enzymology</topic><topic>Organ Size</topic><topic>Pantothenic Acid - deficiency</topic><topic>Phosphoric Diester Hydrolases - metabolism</topic><topic>Pregnancy</topic><topic>Protein Deficiency - enzymology</topic><topic>Rats</topic><topic>Spinal Cord - enzymology</topic><topic>Spinal Cord - pathology</topic><topic>Vitamin A Deficiency - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakhasi, H.L.</creatorcontrib><creatorcontrib>Sharma, Mukut</creatorcontrib><creatorcontrib>Singh, Harfit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakhasi, H.L.</au><au>Sharma, Mukut</au><au>Singh, Harfit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of prenatal and neonatal nutritional deficiencies on the 2′,3′-cyclic nucleotide-3′-phosphohydrolase activity in the brain and spinal cord of rats</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1977-12</date><risdate>1977</risdate><volume>57</volume><issue>3</issue><spage>659</spage><epage>665</epage><pages>659-665</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><abstract>Studies were made of the effects of deficiencies of protein, vitamin A, and pantothenic acid in the maternal diet during gestation and lactation on the activity of 2′,3′-cyclic nucleotide-3′-phosphohydrolase, a myelin marker, in the brain and spinal cord of the progeny. Neonatal and combined prenatal and neonatal protein deficiencies were continued to 14 days of age. At 14 and 21 days of age there was a significant decrease in body, brain, and spinal cord weights. Brain phosphohydrolase activity was significantly decreased in protein- and vitamin A-deficient rats at 21 days of age. However, there was no change in spinal cord activity in any of the experimental manipulations at this age. Protein deficiency at 14 days resulted in a significant decrease in spinal cord and a slight decrease in brain phosphohydrolase activity. Comparison of the control values of phosphohydrolase activity in brain and spinal cord at these ages showed that the spinal cord has a higher activity than the brain.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>200447</pmid><doi>10.1016/0014-4886(77)90099-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4886 |
| ispartof | Experimental neurology, 1977-12, Vol.57 (3), p.659-665 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism Age Factors Animals Animals, Newborn Body Weight Brain - enzymology Brain - pathology Deficiency Diseases - enzymology Female Lactation Maternal-Fetal Exchange Myelin Sheath - enzymology Organ Size Pantothenic Acid - deficiency Phosphoric Diester Hydrolases - metabolism Pregnancy Protein Deficiency - enzymology Rats Spinal Cord - enzymology Spinal Cord - pathology Vitamin A Deficiency - enzymology |
| title | Effects of prenatal and neonatal nutritional deficiencies on the 2′,3′-cyclic nucleotide-3′-phosphohydrolase activity in the brain and spinal cord of rats |
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