Effects of Radiotherapy on Human Parotid Saliva
Changes in parotid salivary function, as determined by flow rate and protein secretion, were measured in 31 cancer patients given radiotherapy to the head and neck. After the first week of treatment, a 50% decrease in salivary flow rate and a 60% decrease in protein secretion rate were observed. Sal...
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| Veröffentlicht in: | Radiat. Res.; (United States) 1981-11, Vol.88 (2), p.403-412 |
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| creator | Mossman, K. L. Shatzman, A. R. Chencharick, J. D. |
| description | Changes in parotid salivary function, as determined by flow rate and protein secretion, were measured in 31 cancer patients given radiotherapy to the head and neck. After the first week of treatment, a 50% decrease in salivary flow rate and a 60% decrease in protein secretion rate were observed. Salivary function remained at or below these levels during the next 3 weeks of treatment. Proteins in saliva were affected unequally, with the family of glycoproteins exhibiting greater sensitivity than amylase. Chromatography or irradiated (60 Gy) and unirradiated whole parotid saliva suggests that the observed alterations in salivary protein may be due to radiation effects on protein synthesis rather than on the proteins themselves. |
| doi_str_mv | 10.2307/3575672 |
| format | Article |
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L. ; Shatzman, A. R. ; Chencharick, J. D.</creator><creatorcontrib>Mossman, K. L. ; Shatzman, A. R. ; Chencharick, J. D. ; Georgetown Univ. Medical Center, Washington, DC</creatorcontrib><description>Changes in parotid salivary function, as determined by flow rate and protein secretion, were measured in 31 cancer patients given radiotherapy to the head and neck. After the first week of treatment, a 50% decrease in salivary flow rate and a 60% decrease in protein secretion rate were observed. Salivary function remained at or below these levels during the next 3 weeks of treatment. Proteins in saliva were affected unequally, with the family of glycoproteins exhibiting greater sensitivity than amylase. Chromatography or irradiated (60 Gy) and unirradiated whole parotid saliva suggests that the observed alterations in salivary protein may be due to radiation effects on protein synthesis rather than on the proteins themselves.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3575672</identifier><identifier>PMID: 6171008</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>550603 - Medicine- External Radiation in Therapy- (1980-) ; 560151 - Radiation Effects on Animals- Man ; Adolescent ; Adult ; Aged ; Amylases - metabolism ; BIOLOGICAL EFFECTS ; BIOLOGICAL MATERIALS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; BODY AREAS ; BODY FLUIDS ; CARBOHYDRATES ; Child ; Chromatography, Gel ; DISEASES ; Estimation methods ; EXTERNAL IRRADIATION ; Female ; Flow velocity ; GLANDS ; GLUCOPROTEINS ; HEAD ; Head and Neck Neoplasms - radiotherapy ; Humans ; IRRADIATION ; Male ; MATERIALS ; MEDICINE ; Middle Aged ; NECK ; NEOPLASMS ; NUCLEAR MEDICINE ; ORGANIC COMPOUNDS ; ORGANS ; Parotid gland ; Parotid Gland - radiation effects ; Parotid Gland - secretion ; PARTIAL BODY IRRADIATION ; PATIENTS ; Protein secretion ; PROTEINS ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; SACCHARIDES ; SALIVA ; Saliva - radiation effects ; Saliva - secretion ; SALIVARY GLANDS ; Salivary proteins ; Salivary Proteins and Peptides - secretion ; Secretion ; SIDE EFFECTS ; Space life sciences ; Spectrophotometry, Ultraviolet ; THERAPY ; Volunteerism ; Xerostomia</subject><ispartof>Radiat. 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L.</creatorcontrib><creatorcontrib>Shatzman, A. R.</creatorcontrib><creatorcontrib>Chencharick, J. D.</creatorcontrib><creatorcontrib>Georgetown Univ. Medical Center, Washington, DC</creatorcontrib><title>Effects of Radiotherapy on Human Parotid Saliva</title><title>Radiat. Res.; (United States)</title><addtitle>Radiat Res</addtitle><description>Changes in parotid salivary function, as determined by flow rate and protein secretion, were measured in 31 cancer patients given radiotherapy to the head and neck. After the first week of treatment, a 50% decrease in salivary flow rate and a 60% decrease in protein secretion rate were observed. Salivary function remained at or below these levels during the next 3 weeks of treatment. Proteins in saliva were affected unequally, with the family of glycoproteins exhibiting greater sensitivity than amylase. Chromatography or irradiated (60 Gy) and unirradiated whole parotid saliva suggests that the observed alterations in salivary protein may be due to radiation effects on protein synthesis rather than on the proteins themselves.</description><subject>550603 - Medicine- External Radiation in Therapy- (1980-)</subject><subject>560151 - Radiation Effects on Animals- Man</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Amylases - metabolism</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>BODY AREAS</subject><subject>BODY FLUIDS</subject><subject>CARBOHYDRATES</subject><subject>Child</subject><subject>Chromatography, Gel</subject><subject>DISEASES</subject><subject>Estimation methods</subject><subject>EXTERNAL IRRADIATION</subject><subject>Female</subject><subject>Flow velocity</subject><subject>GLANDS</subject><subject>GLUCOPROTEINS</subject><subject>HEAD</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>IRRADIATION</subject><subject>Male</subject><subject>MATERIALS</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>NECK</subject><subject>NEOPLASMS</subject><subject>NUCLEAR MEDICINE</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>Parotid gland</subject><subject>Parotid Gland - radiation effects</subject><subject>Parotid Gland - secretion</subject><subject>PARTIAL BODY IRRADIATION</subject><subject>PATIENTS</subject><subject>Protein secretion</subject><subject>PROTEINS</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>SACCHARIDES</subject><subject>SALIVA</subject><subject>Saliva - radiation effects</subject><subject>Saliva - secretion</subject><subject>SALIVARY GLANDS</subject><subject>Salivary proteins</subject><subject>Salivary Proteins and Peptides - secretion</subject><subject>Secretion</subject><subject>SIDE EFFECTS</subject><subject>Space life sciences</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>THERAPY</subject><subject>Volunteerism</subject><subject>Xerostomia</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kN1LwzAUxYMoc07xLxCKiD7VJc3SZI8y5gcMFD-ey91NwjraZiapsP_ejhbffLqce34cDoeQS0bvM07llAspcpkdkTGbc5WKGZ0dkzGlnKdSKHlKzkLY0k6zfD4io5xJRqkak-nSWoMxJM4m76BLFzfGw26fuCZ5bmtokjfwLpY6-YCq_IFzcmKhCuZiuBPy9bj8XDynq9enl8XDKkXOs5giCKb5GiHjqCEDoNYomVuphUILc6HA5JRnOkfLEVFa3T0NWCnsfI2MT8h1n-tCLIuAZTS4Qdc0XdlCKKW4OkC3PbTz7rs1IRZ1GdBUFTTGtaGQXHZtMtqBdz2I3oXgjS12vqzB7wtGi8N-xbBfR14Nke26NvqPGwbr_Jve34bo_L8xv2a5dKM</recordid><startdate>198111</startdate><enddate>198111</enddate><creator>Mossman, K. L.</creator><creator>Shatzman, A. R.</creator><creator>Chencharick, J. D.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198111</creationdate><title>Effects of Radiotherapy on Human Parotid Saliva</title><author>Mossman, K. L. ; Shatzman, A. R. ; Chencharick, J. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-ca51d3bca23cda2aa0fe876f7d58cfa958ae6032d6cf3ccc7fda95eaf75f9bc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>550603 - Medicine- External Radiation in Therapy- (1980-)</topic><topic>560151 - Radiation Effects on Animals- Man</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Amylases - metabolism</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>BODY AREAS</topic><topic>BODY FLUIDS</topic><topic>CARBOHYDRATES</topic><topic>Child</topic><topic>Chromatography, Gel</topic><topic>DISEASES</topic><topic>Estimation methods</topic><topic>EXTERNAL IRRADIATION</topic><topic>Female</topic><topic>Flow velocity</topic><topic>GLANDS</topic><topic>GLUCOPROTEINS</topic><topic>HEAD</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>IRRADIATION</topic><topic>Male</topic><topic>MATERIALS</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>NECK</topic><topic>NEOPLASMS</topic><topic>NUCLEAR MEDICINE</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>Parotid gland</topic><topic>Parotid Gland - radiation effects</topic><topic>Parotid Gland - secretion</topic><topic>PARTIAL BODY IRRADIATION</topic><topic>PATIENTS</topic><topic>Protein secretion</topic><topic>PROTEINS</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>SACCHARIDES</topic><topic>SALIVA</topic><topic>Saliva - radiation effects</topic><topic>Saliva - secretion</topic><topic>SALIVARY GLANDS</topic><topic>Salivary proteins</topic><topic>Salivary Proteins and Peptides - secretion</topic><topic>Secretion</topic><topic>SIDE EFFECTS</topic><topic>Space life sciences</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>THERAPY</topic><topic>Volunteerism</topic><topic>Xerostomia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mossman, K. L.</creatorcontrib><creatorcontrib>Shatzman, A. R.</creatorcontrib><creatorcontrib>Chencharick, J. D.</creatorcontrib><creatorcontrib>Georgetown Univ. 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Res.; (United States)</jtitle><addtitle>Radiat Res</addtitle><date>1981-11</date><risdate>1981</risdate><volume>88</volume><issue>2</issue><spage>403</spage><epage>412</epage><pages>403-412</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>Changes in parotid salivary function, as determined by flow rate and protein secretion, were measured in 31 cancer patients given radiotherapy to the head and neck. After the first week of treatment, a 50% decrease in salivary flow rate and a 60% decrease in protein secretion rate were observed. Salivary function remained at or below these levels during the next 3 weeks of treatment. Proteins in saliva were affected unequally, with the family of glycoproteins exhibiting greater sensitivity than amylase. Chromatography or irradiated (60 Gy) and unirradiated whole parotid saliva suggests that the observed alterations in salivary protein may be due to radiation effects on protein synthesis rather than on the proteins themselves.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>6171008</pmid><doi>10.2307/3575672</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiat. Res.; (United States), 1981-11, Vol.88 (2), p.403-412 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73733220 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | 550603 - Medicine- External Radiation in Therapy- (1980-) 560151 - Radiation Effects on Animals- Man Adolescent Adult Aged Amylases - metabolism BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGICAL RADIATION EFFECTS BODY BODY AREAS BODY FLUIDS CARBOHYDRATES Child Chromatography, Gel DISEASES Estimation methods EXTERNAL IRRADIATION Female Flow velocity GLANDS GLUCOPROTEINS HEAD Head and Neck Neoplasms - radiotherapy Humans IRRADIATION Male MATERIALS MEDICINE Middle Aged NECK NEOPLASMS NUCLEAR MEDICINE ORGANIC COMPOUNDS ORGANS Parotid gland Parotid Gland - radiation effects Parotid Gland - secretion PARTIAL BODY IRRADIATION PATIENTS Protein secretion PROTEINS RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY SACCHARIDES SALIVA Saliva - radiation effects Saliva - secretion SALIVARY GLANDS Salivary proteins Salivary Proteins and Peptides - secretion Secretion SIDE EFFECTS Space life sciences Spectrophotometry, Ultraviolet THERAPY Volunteerism Xerostomia |
| title | Effects of Radiotherapy on Human Parotid Saliva |
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