Regeneration of subnormally innervated axolotl arms
Forearms of juvenile axolotls contain about 5000 axons, of which only 25 % are myelinated and visible by light microscopy. Virtually all the axons degenerate after transection of the brachial plexus, but repeated operations fail to keep the arm completely denervated. Regrown nerve fibres were detect...
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| Veröffentlicht in: | Development (Cambridge) 1981-04, Vol.62 (1), p.1-11 |
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| creator | Wallace, H Watson, A Egar, M |
| description | Forearms of juvenile axolotls contain about 5000 axons, of which only 25 % are myelinated and visible by light microscopy. Virtually all the axons degenerate after transection of the brachial plexus, but repeated operations fail to keep the arm completely denervated. Regrown nerve fibres were detected by electron microscopy after 6 weeks of attempted denervation and related to the quantity usually considered necessary for limb regeneration. Such arms regenerated quite normally, provided their innervation had been depleted for several weeks before amputation. Among other ways of reconciling these observations to the neurotrophic theory of limb regeneration, it is suggested that tissues can adapt to deprivation of their nerve supply. |
| doi_str_mv | 10.1242/dev.62.1.1 |
| format | Article |
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Among other ways of reconciling these observations to the neurotrophic theory of limb regeneration, it is suggested that tissues can adapt to deprivation of their nerve supply.</description><identifier>ISSN: 0950-1991</identifier><identifier>ISSN: 0022-0752</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.62.1.1</identifier><identifier>PMID: 7276803</identifier><language>eng</language><publisher>England: Cambridge University Press for The Company of Biologists Limited</publisher><subject>Ambystoma - physiology ; Ambystoma mexicanum - physiology ; Animals ; Axons - physiology ; Axons - ultrastructure ; Brachial Plexus - physiology ; Extremities - ultrastructure ; Forelimb - innervation ; Forelimb - physiology ; Microscopy, Electron ; Nerve Degeneration ; Nerve Fibers, Myelinated - ultrastructure ; Regeneration ; Schwann Cells - ultrastructure</subject><ispartof>Development (Cambridge), 1981-04, Vol.62 (1), p.1-11</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c190t-7fc35246097e1fc3cc32ad6c56eac51c864517671f9382afaf5b1ccf2908bc703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3664,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7276803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallace, H</creatorcontrib><creatorcontrib>Watson, A</creatorcontrib><creatorcontrib>Egar, M</creatorcontrib><title>Regeneration of subnormally innervated axolotl arms</title><title>Development (Cambridge)</title><addtitle>J Embryol Exp Morphol</addtitle><description>Forearms of juvenile axolotls contain about 5000 axons, of which only 25 % are myelinated and visible by light microscopy. Virtually all the axons degenerate after transection of the brachial plexus, but repeated operations fail to keep the arm completely denervated. Regrown nerve fibres were detected by electron microscopy after 6 weeks of attempted denervation and related to the quantity usually considered necessary for limb regeneration. Such arms regenerated quite normally, provided their innervation had been depleted for several weeks before amputation. Among other ways of reconciling these observations to the neurotrophic theory of limb regeneration, it is suggested that tissues can adapt to deprivation of their nerve supply.</description><subject>Ambystoma - physiology</subject><subject>Ambystoma mexicanum - physiology</subject><subject>Animals</subject><subject>Axons - physiology</subject><subject>Axons - ultrastructure</subject><subject>Brachial Plexus - physiology</subject><subject>Extremities - ultrastructure</subject><subject>Forelimb - innervation</subject><subject>Forelimb - physiology</subject><subject>Microscopy, Electron</subject><subject>Nerve Degeneration</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Regeneration</subject><subject>Schwann Cells - ultrastructure</subject><issn>0950-1991</issn><issn>0022-0752</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN9LwzAUhYMoc05ffBf6JCi05iZt0jzK8BcMBNHnkKbJFmmbmbTT_fd2bPp0L5yPD85B6BJwBiQnd7XZZIxkkMERmkLOeSqAiGM0xaLAKQgBp-gsxk-MMWWcT9CEE85KTKeIvpml6UxQvfNd4m0Sh6rzoVVNs01cNyYb1Zs6UT--8X2TqNDGc3RiVRPNxeHO0Mfjw_v8OV28Pr3M7xepBoH7lFtNC5IzLLiB8deaElUzXTCjdAG6ZHkBnHGwgpZEWWWLCrS2ROCy0hzTGbree9fBfw0m9rJ1UZumUZ3xQ5Sc7moIMoK3e1AHH2MwVq6Da1XYSsByt5AcF5KMSJAwwlcH61C1pv5HD5OM-c0-X7nl6tsFIys3dl-62MedxzR-_ef6BZO-cJ0</recordid><startdate>198104</startdate><enddate>198104</enddate><creator>Wallace, H</creator><creator>Watson, A</creator><creator>Egar, M</creator><general>Cambridge University Press for The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198104</creationdate><title>Regeneration of subnormally innervated axolotl arms</title><author>Wallace, H ; Watson, A ; Egar, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c190t-7fc35246097e1fc3cc32ad6c56eac51c864517671f9382afaf5b1ccf2908bc703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Ambystoma - physiology</topic><topic>Ambystoma mexicanum - physiology</topic><topic>Animals</topic><topic>Axons - physiology</topic><topic>Axons - ultrastructure</topic><topic>Brachial Plexus - physiology</topic><topic>Extremities - ultrastructure</topic><topic>Forelimb - innervation</topic><topic>Forelimb - physiology</topic><topic>Microscopy, Electron</topic><topic>Nerve Degeneration</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Regeneration</topic><topic>Schwann Cells - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallace, H</creatorcontrib><creatorcontrib>Watson, A</creatorcontrib><creatorcontrib>Egar, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallace, H</au><au>Watson, A</au><au>Egar, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regeneration of subnormally innervated axolotl arms</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>J Embryol Exp Morphol</addtitle><date>1981-04</date><risdate>1981</risdate><volume>62</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0950-1991</issn><issn>0022-0752</issn><eissn>1477-9129</eissn><abstract>Forearms of juvenile axolotls contain about 5000 axons, of which only 25 % are myelinated and visible by light microscopy. Virtually all the axons degenerate after transection of the brachial plexus, but repeated operations fail to keep the arm completely denervated. Regrown nerve fibres were detected by electron microscopy after 6 weeks of attempted denervation and related to the quantity usually considered necessary for limb regeneration. Such arms regenerated quite normally, provided their innervation had been depleted for several weeks before amputation. Among other ways of reconciling these observations to the neurotrophic theory of limb regeneration, it is suggested that tissues can adapt to deprivation of their nerve supply.</abstract><cop>England</cop><pub>Cambridge University Press for The Company of Biologists Limited</pub><pmid>7276803</pmid><doi>10.1242/dev.62.1.1</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1981-04, Vol.62 (1), p.1-11 |
| issn | 0950-1991 0022-0752 1477-9129 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Company of Biologists |
| subjects | Ambystoma - physiology Ambystoma mexicanum - physiology Animals Axons - physiology Axons - ultrastructure Brachial Plexus - physiology Extremities - ultrastructure Forelimb - innervation Forelimb - physiology Microscopy, Electron Nerve Degeneration Nerve Fibers, Myelinated - ultrastructure Regeneration Schwann Cells - ultrastructure |
| title | Regeneration of subnormally innervated axolotl arms |
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