Photoaffinity labeling of the beta-adrenergic receptor

A new photoactive beta-adrenergic antagonist, p-azidobenzylcarazolol (pABC) has been synthesized by combining a carbazole moiety with a p-azido-benzyl substituent. The compound has been labeled with tritium to a specific activity of 26 Ci/mmol. In frog erythrocyte membranes, [3H]p-azido-benzylcarazo...

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Veröffentlicht in:	The Journal of biological chemistry 1981-11, Vol.256 (22), p.11944-11950
Hauptverfasser:	Lavin, T N, Heald, S L, Jeffs, P W, Shorr, R G, Lefkowitz, R J, Caron, M G
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels - metabolism Animals Azides beta -adrenergic Binding, Competitive Carbazoles - chemical synthesis Carbazoles - metabolism Erythrocyte Membrane - metabolism erythrocytes Erythrocytes - metabolism frogs Kinetics Molecular Weight photoaffinity labelling Propanolamines Ranidae Receptors, Adrenergic - metabolism Receptors, Adrenergic, beta - isolation & purification Receptors, Adrenergic, beta - metabolism
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