Mechanisms of hydrolysis of adenosine 5'-triphosphate, adenosine 5'-diphosphate, and inorganic pyrophosphate in aqueous perchloric acid
The acid-catalyzed hydrolysis of adenosine 5'-triphosphate (ATP) has been found to give rise both to adenosine 5'-diphosphate (ADP) and inorganic phosphate and to adenosine 5'-phosphate (AMP) and inorganic pyrophosphate. Kinetic and isotope studies on the mechanism of hydrolysis of AT...
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| Veröffentlicht in: | Biochemistry (Easton) 1981-09, Vol.20 (20), p.5809-5816 |
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| container_title | Biochemistry (Easton) |
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| creator | Hutchings, Graham J Banks, Barbara E. C Mruzek, Margaret Ridd, John H Vernon, Charles A |
| description | The acid-catalyzed hydrolysis of adenosine 5'-triphosphate (ATP) has been found to give rise both to adenosine 5'-diphosphate (ADP) and inorganic phosphate and to adenosine 5'-phosphate (AMP) and inorganic pyrophosphate. Kinetic and isotope studies on the mechanism of hydrolysis of ATP therefore depend on a knowledge of the mechanism of hydrolysis of the polyphosphate products, ADP and inorganic pyrophosphate. The latter reactions have been studied over the acidity range 1--5 M perchloric acid at 25 degrees C while the more complex problem of the hydrolysis of ATP has been followed at a single acidity (3 M perchloric acid). The positions of bond fission have been determined for both ATP and ADP. |
| doi_str_mv | 10.1021/bi00523a025 |
| format | Article |
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The latter reactions have been studied over the acidity range 1--5 M perchloric acid at 25 degrees C while the more complex problem of the hydrolysis of ATP has been followed at a single acidity (3 M perchloric acid). The positions of bond fission have been determined for both ATP and ADP.</description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Diphosphates - metabolism</subject><subject>Hydrolysis</subject><subject>Mathematics</subject><subject>Models, Chemical</subject><subject>Perchlorates - pharmacology</subject><issn>0006-2960</issn><issn>1520-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFO3DAQhq2KCpZtTz0j5QQHGjqO42RzRCugVUFU6sLVmtiTxpCNg52V2Cfoa9d0VyuQOFnj79M_o5-xLxzOOGT8W20BZCYQMvmBTbjMIM2rSu6xCQAUaVYVcMAOQ3iIYw5lvs_2i6zkvMon7O8N6RZ7G5YhcU3Sro133TrY_xMa6l2wPSXyJB29HVoXhhZH-voWmTekN4ntnf8TU3UyrL3bwfif4NOK3CokA3ndds5HB7U1n9jHBrtAn7fvlN1dXizm39Pr26sf8_PrFIXMx5QbLagWvNQ1VZUh00iO1MwITFU2QqBBKKCGHJtZLRG4Rq6rGRWcZ7UWUkzZ8SZ38C5eEka1tEFT12H_cpYqRZnlsb0onm5E7V0Inho1eLtEv1Yc1Evt6lXt0T7axq7qJZmdu-058nTDbRjpeYfRP6oirpRq8eu3yn_Or4Bf3qt59E82PuqgHtzK97GUdzf_Az66m9k</recordid><startdate>19810901</startdate><enddate>19810901</enddate><creator>Hutchings, Graham J</creator><creator>Banks, Barbara E. 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| ispartof | Biochemistry (Easton), 1981-09, Vol.20 (20), p.5809-5816 |
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| source | MEDLINE; ACS Publications |
| subjects | Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Diphosphates - metabolism Hydrolysis Mathematics Models, Chemical Perchlorates - pharmacology |
| title | Mechanisms of hydrolysis of adenosine 5'-triphosphate, adenosine 5'-diphosphate, and inorganic pyrophosphate in aqueous perchloric acid |
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