Haemolysis of normal and glutathione-deficient sheep erythrocytes by selenite and tellurite
Both selenite and tellurite caused lysis of normal sheep erythrocytes in vitro. GSH-deficient sheep erythrocytes were considerably more resistant to haemolysis than normal cells. This effect was independent of the biochemical lesion responsible for GSH-deficiency (amino acid transport lesion or γ-gl...
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| Veröffentlicht in: | Biochemical pharmacology 1981-09, Vol.30 (18), p.2527-2530 |
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| container_title | Biochemical pharmacology |
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| creator | Young, James D. Crowley, Charles Tucker, Elizabeth M. |
| description | Both selenite and tellurite caused lysis of normal sheep erythrocytes
in vitro. GSH-deficient sheep erythrocytes were considerably more resistant to haemolysis than normal cells. This effect was independent of the biochemical lesion responsible for GSH-deficiency (amino acid transport lesion or γ-glutamyl cysteine synthetase deficiency). These and other observations directly implicate intracellular GSH in the lytic mechanism. Selenite and tellurite-induced haemolysis therefore provides a simple method for detecting GSH-deficient cells. The lytic effect of selenite may explain some of the symptoms associated with selenium poisoning. |
| doi_str_mv | 10.1016/0006-2952(81)90578-5 |
| format | Article |
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in vitro. GSH-deficient sheep erythrocytes were considerably more resistant to haemolysis than normal cells. This effect was independent of the biochemical lesion responsible for GSH-deficiency (amino acid transport lesion or γ-glutamyl cysteine synthetase deficiency). These and other observations directly implicate intracellular GSH in the lytic mechanism. Selenite and tellurite-induced haemolysis therefore provides a simple method for detecting GSH-deficient cells. The lytic effect of selenite may explain some of the symptoms associated with selenium poisoning.</description><subject>Animals</subject><subject>Erythrocytes - drug effects</subject><subject>Glucose - pharmacology</subject><subject>Glutathione - deficiency</subject><subject>Hemolysis - drug effects</subject><subject>In Vitro Techniques</subject><subject>Selenious Acid</subject><subject>Selenium - pharmacology</subject><subject>Sheep</subject><subject>Tellurium - pharmacology</subject><subject>Time Factors</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-A4WeRA_VfGyT9CKIqCsIXvTkIaTp1I20zZqkQv-9qbvs0dMwM-87Hw9CZwRfE0z4DcaY57Qs6KUkVyUuhMyLPTQjUrBU5nIfzXaSI3QcwteUSk4O0aFgmFNczNDHUkPn2jHYkLkm653vdJvpvs4-2yHquLKuh7yGxhoLfczCCmCdgR_jyjszRghZNWYBWuhthD9jhLYdfMpO0EGj2wCn2zhH748Pb_fL_OX16fn-7iU3VNCYy6pclAbXsqgNJSVLJzY1a0qjhcZFQ8uKSi04LqQAzqDhgoHmpKoqaSrDBJuji83ctXffA4SoOhtMukL34IagBBPpV0aTcLERGu9C8NCotbed9qMiWE1M1URITcCUJOqPqSqS7Xw7f6g6qHemLcTUv930IT35Y8GrMMEyUFsPJqra2f8X_AJO94da</recordid><startdate>19810915</startdate><enddate>19810915</enddate><creator>Young, James D.</creator><creator>Crowley, Charles</creator><creator>Tucker, Elizabeth M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810915</creationdate><title>Haemolysis of normal and glutathione-deficient sheep erythrocytes by selenite and tellurite</title><author>Young, James D. ; Crowley, Charles ; Tucker, Elizabeth M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-8b949c0d85dc2193686fd3f9ca7a05f29b28a760587e63ef673ea61bbb8cbc373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Erythrocytes - drug effects</topic><topic>Glucose - pharmacology</topic><topic>Glutathione - deficiency</topic><topic>Hemolysis - drug effects</topic><topic>In Vitro Techniques</topic><topic>Selenious Acid</topic><topic>Selenium - pharmacology</topic><topic>Sheep</topic><topic>Tellurium - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, James D.</creatorcontrib><creatorcontrib>Crowley, Charles</creatorcontrib><creatorcontrib>Tucker, Elizabeth M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, James D.</au><au>Crowley, Charles</au><au>Tucker, Elizabeth M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haemolysis of normal and glutathione-deficient sheep erythrocytes by selenite and tellurite</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1981-09-15</date><risdate>1981</risdate><volume>30</volume><issue>18</issue><spage>2527</spage><epage>2530</epage><pages>2527-2530</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>Both selenite and tellurite caused lysis of normal sheep erythrocytes
in vitro. GSH-deficient sheep erythrocytes were considerably more resistant to haemolysis than normal cells. This effect was independent of the biochemical lesion responsible for GSH-deficiency (amino acid transport lesion or γ-glutamyl cysteine synthetase deficiency). These and other observations directly implicate intracellular GSH in the lytic mechanism. Selenite and tellurite-induced haemolysis therefore provides a simple method for detecting GSH-deficient cells. The lytic effect of selenite may explain some of the symptoms associated with selenium poisoning.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>7306205</pmid><doi>10.1016/0006-2952(81)90578-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1981-09, Vol.30 (18), p.2527-2530 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Erythrocytes - drug effects Glucose - pharmacology Glutathione - deficiency Hemolysis - drug effects In Vitro Techniques Selenious Acid Selenium - pharmacology Sheep Tellurium - pharmacology Time Factors |
| title | Haemolysis of normal and glutathione-deficient sheep erythrocytes by selenite and tellurite |
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