Degradation Kinetics and Mechanism of Aminocephalosporins in Aqueous Solution: Cefadroxil

The degradation kinetics and mechanism of a new, orally effective cephalosporin derivative, cefadroxil, in aqueous solution were investigated at pH 2.51-11.5 at 35° and ionic strength 0.5. The degradation rates were determined by high-pressure liquid chromatography. At constant pH and temperature, t...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1981-10, Vol.70 (10), p.1120-1128
Hauptverfasser:	Tsuji, Akira, Nakashima, Emi, Deguchi, Yoshiharu, Nishide, Kazunori, Shimizu, Takayoshi, Horiuchi, Sumio, Ishikawa, Kiyoyasu, Yamana, Tsukinaka
Format:	Artikel
Sprache:	eng
Schlagworte:	buffer and temperature effects buffer and temperature effects a pH-rate profile-cefadroxil Buffers Catalysis Cefadroxil Cefadroxil-degradation kinetics and mechanism Cefadroxil—degradation kinetics and mechanism, high-pressure liquid chromatography, pH-rate profile, intramolecular aminolysis to produce piperazinediones, buffer and temperature effects Cephalexin - analogs & derivatives Cephalexin - analysis Chemical Phenomena Chemistry Chemistry, Physical degradation kinetics and mechanism Degradation kinetics-cefadroxil Degradation kinetics—cefadroxil, high-pressure liquid chromatography assay, pH-rate profile, intramolecular aminolysis to produce piperazinediones, buffer and temperature effects a pH-rate profile—cefadroxil, degradation kinetics and mechanism, intramolecular aminolysis to produce piperazinediones, buffer and temperature effects Drug Stability high-pressure liquid chromatography high-pressure liquid chromatography assay Hydrogen-Ion Concentration in-tramolecular aminolysis intramolecular aminolysis to produce piperazinediones Kinetics pH-rate profile Piperazinediones-cefadroxil degradation kinetics and mechanism Piperazinediones—cefadroxil degradation kinetics and mechanism, in-tramolecular aminolysis Temperature
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