Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes
An insulin-dependent diabetic condition was induced in male Sprague-Dawley rats by strptozotocin injection. Ten days after administration of the diabetogenic drug, tissue levels of copper, zinc, iron and manganese were determined and compared to control animals. Increased quantities of hepatic coppe...
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| Veröffentlicht in: | The Journal of nutrition 1981-11, Vol.111 (11), p.1900-1909 |
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| container_end_page | 1909 |
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| container_issue | 11 |
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| container_title | The Journal of nutrition |
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| creator | Failla, Mark L. Kiser, Rebecca A. |
| description | An insulin-dependent diabetic condition was induced in male Sprague-Dawley rats by strptozotocin injection. Ten days after administration of the diabetogenic drug, tissue levels of copper, zinc, iron and manganese were determined and compared to control animals. Increased quantities of hepatic copper, zinc and manganese, renal copper and zinc and plasma zinc were observed in the diabetic group. Intestinal, muscle and spleen contents of the metals were similar in control and diabetic rats. Elevated levels of zinc- and copper-metallothionein were found in liver and kidney of diabetic rats. The distribution of zinc among soluble proteins in the diabetic liver was also altered. Daily administration of insulin to diabetic rats returned the trace metal content of tissues, intracellular distribution of zinc and the quantity of zinc- and copper-metallothionein to normal levels. Pair-feeding copper, zinc, iron and copper-metallothionein to normal levels. Pair-feeding copper, zinc, iron and manganese to diabetic and control groups demonstrated that the enhanced food consumption of the diabetic rat was not a significant factor in the observed accumulation of trace metals in liver and kidney. These data suggest that the hormonal imbalance characteristic of the insulin-dependent diabetic condition influences trace metal metabolism. These studies also demonstrate the usefulness of the streptozotocin-diabetic rat as an animal model for investigations concerning hormone-mediated regulation of trace metal metabolism.
copper zinc manganese iron diabetes trace elements |
| doi_str_mv | 10.1093/jn/111.11.1900 |
| format | Article |
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copper zinc manganese iron diabetes trace elements</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/111.11.1900</identifier><identifier>PMID: 7028924</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; copper ; Copper - metabolism ; Cytosol - metabolism ; Diabetes Mellitus, Experimental - metabolism ; Insulin - pharmacology ; iron ; Iron - metabolism ; Kidney - metabolism ; Liver - metabolism ; Male ; manganese ; Manganese - metabolism ; Rats ; Rats, Inbred Strains ; Tissue Distribution ; zinc ; Zinc - blood ; Zinc - metabolism</subject><ispartof>The Journal of nutrition, 1981-11, Vol.111 (11), p.1900-1909</ispartof><rights>1981 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-124a5fb0f921efcda73ea73092b1809c3e43acc657635f81f73b776391df9d453</citedby><cites>FETCH-LOGICAL-c469t-124a5fb0f921efcda73ea73092b1809c3e43acc657635f81f73b776391df9d453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7028924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Failla, Mark L.</creatorcontrib><creatorcontrib>Kiser, Rebecca A.</creatorcontrib><title>Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>An insulin-dependent diabetic condition was induced in male Sprague-Dawley rats by strptozotocin injection. Ten days after administration of the diabetogenic drug, tissue levels of copper, zinc, iron and manganese were determined and compared to control animals. Increased quantities of hepatic copper, zinc and manganese, renal copper and zinc and plasma zinc were observed in the diabetic group. Intestinal, muscle and spleen contents of the metals were similar in control and diabetic rats. Elevated levels of zinc- and copper-metallothionein were found in liver and kidney of diabetic rats. The distribution of zinc among soluble proteins in the diabetic liver was also altered. Daily administration of insulin to diabetic rats returned the trace metal content of tissues, intracellular distribution of zinc and the quantity of zinc- and copper-metallothionein to normal levels. Pair-feeding copper, zinc, iron and copper-metallothionein to normal levels. Pair-feeding copper, zinc, iron and manganese to diabetic and control groups demonstrated that the enhanced food consumption of the diabetic rat was not a significant factor in the observed accumulation of trace metals in liver and kidney. These data suggest that the hormonal imbalance characteristic of the insulin-dependent diabetic condition influences trace metal metabolism. These studies also demonstrate the usefulness of the streptozotocin-diabetic rat as an animal model for investigations concerning hormone-mediated regulation of trace metal metabolism.
copper zinc manganese iron diabetes trace elements</description><subject>Animals</subject><subject>copper</subject><subject>Copper - metabolism</subject><subject>Cytosol - metabolism</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Insulin - pharmacology</subject><subject>iron</subject><subject>Iron - metabolism</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>manganese</subject><subject>Manganese - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tissue Distribution</subject><subject>zinc</subject><subject>Zinc - blood</subject><subject>Zinc - metabolism</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVpSLdpr72V6tSbNzOWbVnHsEk_ICWHbKA3IcujosVrbSW5NP8-WnbprTBCgveZGfEw9gFhjaDE9W6-RsT1sRTAK7bCtsGqQ4DXbAVQ15XArnvD3qa0AwBsVH_JLiXUvaqbFft5M2WKNPKtT2khvglzpjlzM49885xDChO_9SlHPyzZh5kHx7fRWOI_KJspcT_zu78Hin5f2swRNgNlSu_YhSs5vT_fV-zpy9128626f_j6fXNzX9mmU7nCujGtG8CpGsnZ0UhB5YCqB-xBWUGNMNZ2rexE63p0UgyyvBWOTo1NK67Y59PcQwy_F0pZ732yNE1mprAkLYXEXglRwPUJtDGkFMnpQ_m0ic8aQR9V6t2si0p9rKKyNHw8T16GPY3_8LO7kn865c4EbX5Fn_TTYw0oAJXspOwL0Z8IKgL-eIo6WU-zpdFHslmPwf9v-Qu6fYrV</recordid><startdate>198111</startdate><enddate>198111</enddate><creator>Failla, Mark L.</creator><creator>Kiser, Rebecca A.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198111</creationdate><title>Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes</title><author>Failla, Mark L. ; Kiser, Rebecca A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-124a5fb0f921efcda73ea73092b1809c3e43acc657635f81f73b776391df9d453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>copper</topic><topic>Copper - metabolism</topic><topic>Cytosol - metabolism</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Insulin - pharmacology</topic><topic>iron</topic><topic>Iron - metabolism</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>manganese</topic><topic>Manganese - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tissue Distribution</topic><topic>zinc</topic><topic>Zinc - blood</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Failla, Mark L.</creatorcontrib><creatorcontrib>Kiser, Rebecca A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Failla, Mark L.</au><au>Kiser, Rebecca A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1981-11</date><risdate>1981</risdate><volume>111</volume><issue>11</issue><spage>1900</spage><epage>1909</epage><pages>1900-1909</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>An insulin-dependent diabetic condition was induced in male Sprague-Dawley rats by strptozotocin injection. Ten days after administration of the diabetogenic drug, tissue levels of copper, zinc, iron and manganese were determined and compared to control animals. Increased quantities of hepatic copper, zinc and manganese, renal copper and zinc and plasma zinc were observed in the diabetic group. Intestinal, muscle and spleen contents of the metals were similar in control and diabetic rats. Elevated levels of zinc- and copper-metallothionein were found in liver and kidney of diabetic rats. The distribution of zinc among soluble proteins in the diabetic liver was also altered. Daily administration of insulin to diabetic rats returned the trace metal content of tissues, intracellular distribution of zinc and the quantity of zinc- and copper-metallothionein to normal levels. Pair-feeding copper, zinc, iron and copper-metallothionein to normal levels. Pair-feeding copper, zinc, iron and manganese to diabetic and control groups demonstrated that the enhanced food consumption of the diabetic rat was not a significant factor in the observed accumulation of trace metals in liver and kidney. These data suggest that the hormonal imbalance characteristic of the insulin-dependent diabetic condition influences trace metal metabolism. These studies also demonstrate the usefulness of the streptozotocin-diabetic rat as an animal model for investigations concerning hormone-mediated regulation of trace metal metabolism.
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| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 1981-11, Vol.111 (11), p.1900-1909 |
| issn | 0022-3166 1541-6100 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals copper Copper - metabolism Cytosol - metabolism Diabetes Mellitus, Experimental - metabolism Insulin - pharmacology iron Iron - metabolism Kidney - metabolism Liver - metabolism Male manganese Manganese - metabolism Rats Rats, Inbred Strains Tissue Distribution zinc Zinc - blood Zinc - metabolism |
| title | Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes |
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