Effects of methamphetamine on novelty-seeking behaviour by mice
The effects of several doses from 0.125-3 mg/kg of methamphetamine on the novelty-seeking behaviour of male Swiss albino mice were studied. Methamphetamine induced a dose-dependent inhibition of novelty preference. Furthermore, a dose of methamphetamine (1 mg/kg) which strongly decreased novelty pre...
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| Veröffentlicht in: | Psychopharmacology 1981-01, Vol.75 (1), p.39-43 |
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| container_title | Psychopharmacology |
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| creator | Misslin, R Ropartz, P |
| description | The effects of several doses from 0.125-3 mg/kg of methamphetamine on the novelty-seeking behaviour of male Swiss albino mice were studied. Methamphetamine induced a dose-dependent inhibition of novelty preference. Furthermore, a dose of methamphetamine (1 mg/kg) which strongly decreased novelty preference in naive mice induced a significantly lower decrease in exploration of subjects previously exposed to novelty. These data provide some support for Berlyne's (1967) suggestion that amphetamine has a disruptive effect on exploration by producing over-arousal. |
| doi_str_mv | 10.1007/BF00433499 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Psychopharmacology, 1981-01, Vol.75 (1), p.39-43 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Arousal - drug effects Exploratory Behavior - drug effects Locomotion - drug effects Male Methamphetamine - administration & dosage Methamphetamine - pharmacology Mice |
| title | Effects of methamphetamine on novelty-seeking behaviour by mice |
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