Combined effects of angiotensin II and ACTH on cortisol production: In vitro studies on isolated guinea-pig adrenal cells
The effects of angiotensin on cortisol production and ACTH-induced cortisol production have been studied in isolated guinea-pig adrenal cells. At pharmacological doses of μg/ml, angiotensin proved to be a stimulatory hormone for cortisol production. Its effects were additive to those of ACTH. Two-hu...
Gespeichert in:
| Veröffentlicht in: | Journal of steroid biochemistry 1981-09, Vol.14 (9), p.929-934 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 934 |
|---|---|
| container_issue | 9 |
| container_start_page | 929 |
| container_title | Journal of steroid biochemistry |
| container_volume | 14 |
| creator | Pham-Huu-Trung, Marie-T. Lombes, M. Bogyo, A. Girard, F. |
| description | The effects of angiotensin on cortisol production and ACTH-induced cortisol production have been studied in isolated guinea-pig adrenal cells. At pharmacological doses of μg/ml, angiotensin proved to be a stimulatory hormone for cortisol production. Its effects were additive to those of ACTH. Two-hundred and fifty picograms of angiotensin, which alone were ineffective in provoking any detectable cortisol output, were able to inhibit the cortisol production induced by physiological concentrations of ACTH. The decrease in cortisol was slight but significant, yet it occurred within so narrow a concentration range of angiotensin that its real physiological significance can be questioned. |
| doi_str_mv | 10.1016/0022-4731(81)90242-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73714935</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0022473181902429</els_id><sourcerecordid>73714935</sourcerecordid><originalsourceid>FETCH-LOGICAL-c272t-3bef2ace9822e1168e30588ab1662369225884cc864c25b11dc8ff91c767dce53</originalsourceid><addsrcrecordid>eNp9kE9PAyEQxTlotP75BppwMnpYBXbLsh5MmkZtExMveiYszDaYLVRgm_jtZW3To6fJzLx5PH4IXVFyTwnlD4QwVlR1SW8FvWsIq1jRHKHJYXyKzmL8IoQ2omIn6ISzmhHGJ-hn7tetdWAwdB3oFLHvsHIr6xO4aB1eLnNr8Gz-scDeYe1DstH3eBO8GXSy3j3ipcNbm4LHMQ3GQhyFo0il7Lsasr0qNnaFlQngVI819H28QMed6iNc7us5-nx5_pgvirf31-V89lbonDEVZQsdUxoawRhQygWUZCqEainnrOQNY7mrtBa80mzaUmq06LqG6prXRsO0PEc3O9-c-HuAmOTaxjGBcuCHKOuyplVTjsJqJ9TBxxigk5tg1yr8SErkSFmOOOWIUwoq_yjLJp9d7_2Hdg3mcLRHnPdPuz3kT24tBBm1BafB2JCBS-Pt_w_8Asn3jh4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73714935</pqid></control><display><type>article</type><title>Combined effects of angiotensin II and ACTH on cortisol production: In vitro studies on isolated guinea-pig adrenal cells</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Pham-Huu-Trung, Marie-T. ; Lombes, M. ; Bogyo, A. ; Girard, F.</creator><creatorcontrib>Pham-Huu-Trung, Marie-T. ; Lombes, M. ; Bogyo, A. ; Girard, F.</creatorcontrib><description>The effects of angiotensin on cortisol production and ACTH-induced cortisol production have been studied in isolated guinea-pig adrenal cells. At pharmacological doses of μg/ml, angiotensin proved to be a stimulatory hormone for cortisol production. Its effects were additive to those of ACTH. Two-hundred and fifty picograms of angiotensin, which alone were ineffective in provoking any detectable cortisol output, were able to inhibit the cortisol production induced by physiological concentrations of ACTH. The decrease in cortisol was slight but significant, yet it occurred within so narrow a concentration range of angiotensin that its real physiological significance can be questioned.</description><identifier>ISSN: 0022-4731</identifier><identifier>DOI: 10.1016/0022-4731(81)90242-9</identifier><identifier>PMID: 6272026</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adrenal Glands - drug effects ; Adrenal Glands - metabolism ; Adrenocorticotropic Hormone - pharmacology ; Angiotensin II - pharmacology ; Animals ; Cortodoxone - metabolism ; Dose-Response Relationship, Drug ; Guinea Pigs ; Hydrocortisone - biosynthesis ; Hydroxyprogesterones - metabolism ; In Vitro Techniques ; Male</subject><ispartof>Journal of steroid biochemistry, 1981-09, Vol.14 (9), p.929-934</ispartof><rights>1981</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-3bef2ace9822e1168e30588ab1662369225884cc864c25b11dc8ff91c767dce53</citedby><cites>FETCH-LOGICAL-c272t-3bef2ace9822e1168e30588ab1662369225884cc864c25b11dc8ff91c767dce53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6272026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pham-Huu-Trung, Marie-T.</creatorcontrib><creatorcontrib>Lombes, M.</creatorcontrib><creatorcontrib>Bogyo, A.</creatorcontrib><creatorcontrib>Girard, F.</creatorcontrib><title>Combined effects of angiotensin II and ACTH on cortisol production: In vitro studies on isolated guinea-pig adrenal cells</title><title>Journal of steroid biochemistry</title><addtitle>J Steroid Biochem</addtitle><description>The effects of angiotensin on cortisol production and ACTH-induced cortisol production have been studied in isolated guinea-pig adrenal cells. At pharmacological doses of μg/ml, angiotensin proved to be a stimulatory hormone for cortisol production. Its effects were additive to those of ACTH. Two-hundred and fifty picograms of angiotensin, which alone were ineffective in provoking any detectable cortisol output, were able to inhibit the cortisol production induced by physiological concentrations of ACTH. The decrease in cortisol was slight but significant, yet it occurred within so narrow a concentration range of angiotensin that its real physiological significance can be questioned.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Cortodoxone - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Guinea Pigs</subject><subject>Hydrocortisone - biosynthesis</subject><subject>Hydroxyprogesterones - metabolism</subject><subject>In Vitro Techniques</subject><subject>Male</subject><issn>0022-4731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PAyEQxTlotP75BppwMnpYBXbLsh5MmkZtExMveiYszDaYLVRgm_jtZW3To6fJzLx5PH4IXVFyTwnlD4QwVlR1SW8FvWsIq1jRHKHJYXyKzmL8IoQ2omIn6ISzmhHGJ-hn7tetdWAwdB3oFLHvsHIr6xO4aB1eLnNr8Gz-scDeYe1DstH3eBO8GXSy3j3ipcNbm4LHMQ3GQhyFo0il7Lsasr0qNnaFlQngVI819H28QMed6iNc7us5-nx5_pgvirf31-V89lbonDEVZQsdUxoawRhQygWUZCqEainnrOQNY7mrtBa80mzaUmq06LqG6prXRsO0PEc3O9-c-HuAmOTaxjGBcuCHKOuyplVTjsJqJ9TBxxigk5tg1yr8SErkSFmOOOWIUwoq_yjLJp9d7_2Hdg3mcLRHnPdPuz3kT24tBBm1BafB2JCBS-Pt_w_8Asn3jh4</recordid><startdate>198109</startdate><enddate>198109</enddate><creator>Pham-Huu-Trung, Marie-T.</creator><creator>Lombes, M.</creator><creator>Bogyo, A.</creator><creator>Girard, F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198109</creationdate><title>Combined effects of angiotensin II and ACTH on cortisol production: In vitro studies on isolated guinea-pig adrenal cells</title><author>Pham-Huu-Trung, Marie-T. ; Lombes, M. ; Bogyo, A. ; Girard, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-3bef2ace9822e1168e30588ab1662369225884cc864c25b11dc8ff91c767dce53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Cortodoxone - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Guinea Pigs</topic><topic>Hydrocortisone - biosynthesis</topic><topic>Hydroxyprogesterones - metabolism</topic><topic>In Vitro Techniques</topic><topic>Male</topic><toplevel>online_resources</toplevel><creatorcontrib>Pham-Huu-Trung, Marie-T.</creatorcontrib><creatorcontrib>Lombes, M.</creatorcontrib><creatorcontrib>Bogyo, A.</creatorcontrib><creatorcontrib>Girard, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of steroid biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pham-Huu-Trung, Marie-T.</au><au>Lombes, M.</au><au>Bogyo, A.</au><au>Girard, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined effects of angiotensin II and ACTH on cortisol production: In vitro studies on isolated guinea-pig adrenal cells</atitle><jtitle>Journal of steroid biochemistry</jtitle><addtitle>J Steroid Biochem</addtitle><date>1981-09</date><risdate>1981</risdate><volume>14</volume><issue>9</issue><spage>929</spage><epage>934</epage><pages>929-934</pages><issn>0022-4731</issn><abstract>The effects of angiotensin on cortisol production and ACTH-induced cortisol production have been studied in isolated guinea-pig adrenal cells. At pharmacological doses of μg/ml, angiotensin proved to be a stimulatory hormone for cortisol production. Its effects were additive to those of ACTH. Two-hundred and fifty picograms of angiotensin, which alone were ineffective in provoking any detectable cortisol output, were able to inhibit the cortisol production induced by physiological concentrations of ACTH. The decrease in cortisol was slight but significant, yet it occurred within so narrow a concentration range of angiotensin that its real physiological significance can be questioned.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>6272026</pmid><doi>10.1016/0022-4731(81)90242-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4731 |
| ispartof | Journal of steroid biochemistry, 1981-09, Vol.14 (9), p.929-934 |
| issn | 0022-4731 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73714935 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenocorticotropic Hormone - pharmacology Angiotensin II - pharmacology Animals Cortodoxone - metabolism Dose-Response Relationship, Drug Guinea Pigs Hydrocortisone - biosynthesis Hydroxyprogesterones - metabolism In Vitro Techniques Male |
| title | Combined effects of angiotensin II and ACTH on cortisol production: In vitro studies on isolated guinea-pig adrenal cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T17%3A43%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20effects%20of%20angiotensin%20II%20and%20ACTH%20on%20cortisol%20production:%20In%20vitro%20studies%20on%20isolated%20guinea-pig%20adrenal%20cells&rft.jtitle=Journal%20of%20steroid%20biochemistry&rft.au=Pham-Huu-Trung,%20Marie-T.&rft.date=1981-09&rft.volume=14&rft.issue=9&rft.spage=929&rft.epage=934&rft.pages=929-934&rft.issn=0022-4731&rft_id=info:doi/10.1016/0022-4731(81)90242-9&rft_dat=%3Cproquest_cross%3E73714935%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73714935&rft_id=info:pmid/6272026&rft_els_id=0022473181902429&rfr_iscdi=true |