Hypercalcemia in carcinoma of the breast without evidence of bone destruction: Beneficial effect of hormonal therapy
A premenopausal woman with soft tissue metastases from a carcinoma of the breast developed hypercalcemia with hypophosphatemia, reduced tubular reabsorption of phosphate, elevated urinary cyclic AMP levels and normal serum PTH levels. During the course of the disease, metastatic pleural effusion whi...
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| Veröffentlicht in: | Cancer 1981-12, Vol.48 (11), p.2383-2385 |
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| container_issue | 11 |
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| container_title | Cancer |
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| creator | Sztern, Mario Barkan, Ariel Marilus, Raphael Blum, Ilana Rakowsky, Erika Shainkin‐Kestenbaum, Ruth |
| description | A premenopausal woman with soft tissue metastases from a carcinoma of the breast developed hypercalcemia with hypophosphatemia, reduced tubular reabsorption of phosphate, elevated urinary cyclic AMP levels and normal serum PTH levels. During the course of the disease, metastatic pleural effusion which contained high PTH levels was observed. Hormonal therapy with testosterone followed by tamoxifen induced normalization of her serum calcium concomitant with the disappearance of the pleural effusion and reduction in the size of her lung metastases. The correlation between the efficacy of antitumor treatment on pleural effusion, lung metastases, and normalization of serum calcium, as well as the elevated PTH level in the pleural effusion, suggest that this breast carcinoma secreted a PTH‐like substance. |
| doi_str_mv | 10.1002/1097-0142(19811201)48:11<2383::AID-CNCR2820481108>3.0.CO;2-N |
| format | Article |
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During the course of the disease, metastatic pleural effusion which contained high PTH levels was observed. Hormonal therapy with testosterone followed by tamoxifen induced normalization of her serum calcium concomitant with the disappearance of the pleural effusion and reduction in the size of her lung metastases. The correlation between the efficacy of antitumor treatment on pleural effusion, lung metastases, and normalization of serum calcium, as well as the elevated PTH level in the pleural effusion, suggest that this breast carcinoma secreted a PTH‐like substance.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19811201)48:11<2383::AID-CNCR2820481108>3.0.CO;2-N</identifier><identifier>PMID: 7296487</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Breast Neoplasms - complications ; Breast Neoplasms - metabolism ; Female ; Hormones, Ectopic - biosynthesis ; Humans ; Hypercalcemia - drug therapy ; Hypercalcemia - etiology ; Lung Neoplasms - drug therapy ; Lung Neoplasms - secondary ; Parathyroid Hormone - metabolism ; Pleural Effusion - drug therapy ; Pleural Effusion - etiology ; Tamoxifen - therapeutic use ; Testosterone - therapeutic use</subject><ispartof>Cancer, 1981-12, Vol.48 (11), p.2383-2385</ispartof><rights>Copyright © 1981 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4188-6d4bce9b0703b1849281cab0c15f7908e24ea331cca8a49c7f017170e705210d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7296487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sztern, Mario</creatorcontrib><creatorcontrib>Barkan, Ariel</creatorcontrib><creatorcontrib>Marilus, Raphael</creatorcontrib><creatorcontrib>Blum, Ilana</creatorcontrib><creatorcontrib>Rakowsky, Erika</creatorcontrib><creatorcontrib>Shainkin‐Kestenbaum, Ruth</creatorcontrib><title>Hypercalcemia in carcinoma of the breast without evidence of bone destruction: Beneficial effect of hormonal therapy</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A premenopausal woman with soft tissue metastases from a carcinoma of the breast developed hypercalcemia with hypophosphatemia, reduced tubular reabsorption of phosphate, elevated urinary cyclic AMP levels and normal serum PTH levels. During the course of the disease, metastatic pleural effusion which contained high PTH levels was observed. Hormonal therapy with testosterone followed by tamoxifen induced normalization of her serum calcium concomitant with the disappearance of the pleural effusion and reduction in the size of her lung metastases. The correlation between the efficacy of antitumor treatment on pleural effusion, lung metastases, and normalization of serum calcium, as well as the elevated PTH level in the pleural effusion, suggest that this breast carcinoma secreted a PTH‐like substance.</description><subject>Adult</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - metabolism</subject><subject>Female</subject><subject>Hormones, Ectopic - biosynthesis</subject><subject>Humans</subject><subject>Hypercalcemia - drug therapy</subject><subject>Hypercalcemia - etiology</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - secondary</subject><subject>Parathyroid Hormone - metabolism</subject><subject>Pleural Effusion - drug therapy</subject><subject>Pleural Effusion - etiology</subject><subject>Tamoxifen - therapeutic use</subject><subject>Testosterone - therapeutic use</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkVGL1DAUhYso6-zqTxDyJPrQ8d4knaTjIqxddReWGRAFH4SQZm6dSNuMabvL_HtbZlzQB8WnkJyTcy_nS5JLhDkC8FcIuUoBJX-BuUbkgC-lXiKec6HFcnlxfZkWq-Ij1xzkqIN-I-YwL9avebp6kMzuvz9MZgCg00yKL4-T0677Pl4Vz8RJcqJ4vpBazZL-ar-j6GztqPGW-ZY5G51vQ2NZqFi_JVZGsl3P7ny_DUPP6NZvqHU0yWVoiW2o6-Pgeh_aJXtLLVXeeVszqipy_WTbhtiEdnwa46Ld7Z8kjypbd_T0eJ4ln9-_-1RcpTfrD9fFxU3qJGqdLjaydJSXoECUqGXONTpbgsOsUjlo4pKsEOic1VbmTlWAChWQgowjbMRZ8vyQu4vhxzCuaRrfOapr21IYOqOEQrnI838aMcvG5nI-Gr8ejC6GrotUmV30jY17g2Amemaq30z1m1_0jNQG0Uz0jBnpmd_pGWHAFGvDzWqMf3bcYygb2tyHH3GN-reDfudr2v_n7L-O_kMRPwFh_Lhs</recordid><startdate>19811201</startdate><enddate>19811201</enddate><creator>Sztern, Mario</creator><creator>Barkan, Ariel</creator><creator>Marilus, Raphael</creator><creator>Blum, Ilana</creator><creator>Rakowsky, Erika</creator><creator>Shainkin‐Kestenbaum, Ruth</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19811201</creationdate><title>Hypercalcemia in carcinoma of the breast without evidence of bone destruction: Beneficial effect of hormonal therapy</title><author>Sztern, Mario ; Barkan, Ariel ; Marilus, Raphael ; Blum, Ilana ; Rakowsky, Erika ; Shainkin‐Kestenbaum, Ruth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4188-6d4bce9b0703b1849281cab0c15f7908e24ea331cca8a49c7f017170e705210d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - metabolism</topic><topic>Female</topic><topic>Hormones, Ectopic - biosynthesis</topic><topic>Humans</topic><topic>Hypercalcemia - drug therapy</topic><topic>Hypercalcemia - etiology</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - secondary</topic><topic>Parathyroid Hormone - metabolism</topic><topic>Pleural Effusion - drug therapy</topic><topic>Pleural Effusion - etiology</topic><topic>Tamoxifen - therapeutic use</topic><topic>Testosterone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sztern, Mario</creatorcontrib><creatorcontrib>Barkan, Ariel</creatorcontrib><creatorcontrib>Marilus, Raphael</creatorcontrib><creatorcontrib>Blum, Ilana</creatorcontrib><creatorcontrib>Rakowsky, Erika</creatorcontrib><creatorcontrib>Shainkin‐Kestenbaum, Ruth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sztern, Mario</au><au>Barkan, Ariel</au><au>Marilus, Raphael</au><au>Blum, Ilana</au><au>Rakowsky, Erika</au><au>Shainkin‐Kestenbaum, Ruth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypercalcemia in carcinoma of the breast without evidence of bone destruction: Beneficial effect of hormonal therapy</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1981-12-01</date><risdate>1981</risdate><volume>48</volume><issue>11</issue><spage>2383</spage><epage>2385</epage><pages>2383-2385</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>A premenopausal woman with soft tissue metastases from a carcinoma of the breast developed hypercalcemia with hypophosphatemia, reduced tubular reabsorption of phosphate, elevated urinary cyclic AMP levels and normal serum PTH levels. During the course of the disease, metastatic pleural effusion which contained high PTH levels was observed. Hormonal therapy with testosterone followed by tamoxifen induced normalization of her serum calcium concomitant with the disappearance of the pleural effusion and reduction in the size of her lung metastases. The correlation between the efficacy of antitumor treatment on pleural effusion, lung metastases, and normalization of serum calcium, as well as the elevated PTH level in the pleural effusion, suggest that this breast carcinoma secreted a PTH‐like substance.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7296487</pmid><doi>10.1002/1097-0142(19811201)48:11<2383::AID-CNCR2820481108>3.0.CO;2-N</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1981-12, Vol.48 (11), p.2383-2385 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Breast Neoplasms - complications Breast Neoplasms - metabolism Female Hormones, Ectopic - biosynthesis Humans Hypercalcemia - drug therapy Hypercalcemia - etiology Lung Neoplasms - drug therapy Lung Neoplasms - secondary Parathyroid Hormone - metabolism Pleural Effusion - drug therapy Pleural Effusion - etiology Tamoxifen - therapeutic use Testosterone - therapeutic use |
| title | Hypercalcemia in carcinoma of the breast without evidence of bone destruction: Beneficial effect of hormonal therapy |
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