Oxygen and glucose consumption related to Na+-K+ transport in canine brain
This study examines the relation between Na+-K+ transport and metabolism in the canine brain. Cerebral oxygen and glucose consumption was measured by the sagittal sinus outflow technique. Synaptic transmission and related metabolism was blocked by pentobarbital 40 mg/kg (EEG flat). Lidocaine blocked...
Gespeichert in:
| Veröffentlicht in: | Stroke (1970) 1981-11, Vol.12 (6), p.726-730 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 730 |
|---|---|
| container_issue | 6 |
| container_start_page | 726 |
| container_title | Stroke (1970) |
| container_volume | 12 |
| creator | Astrup, J Sørensen, P M Sørensen, H R |
| description | This study examines the relation between Na+-K+ transport and metabolism in the canine brain. Cerebral oxygen and glucose consumption was measured by the sagittal sinus outflow technique. Synaptic transmission and related metabolism was blocked by pentobarbital 40 mg/kg (EEG flat). Lidocaine blocked an additional 15-20%, presumable by restricting Na+-K+ leak fluxes and reducing the demand for Na+-K+ transport. Ouabain blocked an additional 20-25% of metabolism. Ouabain also inhibited the Na+-K+ sensitive ATPase associated transport and caused a net efflux of K+ from the cellular compartment as evidenced by an increasing extracellular K+ concentration in the cortex. Accordingly, a total of 40% of metabolism in te EEG-arrested barbiturate inhibited brain could be related to Na+-K+ leak fluxes and associated transport. The remaining 60% are related to processes unidentified by this study. It is concluded that cerebral metabolism may be reduced below the hitherto described barbiturate minimum. |
| doi_str_mv | 10.1161/01.str.12.6.726 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73714365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73714365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-44472b6b2759a616075c07be9b10538008df3564e8d67abe9269e786e412df3</originalsourceid><addsrcrecordid>eNo9kM1LwzAYxoMoc07PnoScvIx2bz6atEcZfg8HbveQttmotElNUnD_vZUNTw-8z-99Dj-EbgmkhAiyAJKG6FNCU5FKKs7QlGSUJ1zQ_BxNAViRUF4Ul-gqhC8AoCzPJmgiGTAQZIre1j-HvbFY2xrv26FyweDK2TB0fWycxd60OpoaR4c_9Dx5n-PotQ298xE3FlfaNtbg0uvGXqOLnW6DuTnlDG2eHrfLl2S1fn5dPqySiucQE865pKUoqcwKLYgAmVUgS1OUBDKWA-T1jmWCm7wWUo93Kgojc2E4oWMzQ_fH1d6778GEqLomVKZttTVuCEoySTgT2QgujmDlXQje7FTvm077gyKg_twpIGqz_VSEKqFGd-PH3Wl6KDtT__MnWewX6PJo6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73714365</pqid></control><display><type>article</type><title>Oxygen and glucose consumption related to Na+-K+ transport in canine brain</title><source>Journals@Ovid Ovid Autoload</source><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Astrup, J ; Sørensen, P M ; Sørensen, H R</creator><creatorcontrib>Astrup, J ; Sørensen, P M ; Sørensen, H R</creatorcontrib><description>This study examines the relation between Na+-K+ transport and metabolism in the canine brain. Cerebral oxygen and glucose consumption was measured by the sagittal sinus outflow technique. Synaptic transmission and related metabolism was blocked by pentobarbital 40 mg/kg (EEG flat). Lidocaine blocked an additional 15-20%, presumable by restricting Na+-K+ leak fluxes and reducing the demand for Na+-K+ transport. Ouabain blocked an additional 20-25% of metabolism. Ouabain also inhibited the Na+-K+ sensitive ATPase associated transport and caused a net efflux of K+ from the cellular compartment as evidenced by an increasing extracellular K+ concentration in the cortex. Accordingly, a total of 40% of metabolism in te EEG-arrested barbiturate inhibited brain could be related to Na+-K+ leak fluxes and associated transport. The remaining 60% are related to processes unidentified by this study. It is concluded that cerebral metabolism may be reduced below the hitherto described barbiturate minimum.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.str.12.6.726</identifier><identifier>PMID: 7303061</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Biological Transport ; Brain - metabolism ; Dogs ; Electroencephalography ; Glucose - metabolism ; Lidocaine - pharmacology ; Ouabain - pharmacology ; Oxygen Consumption ; Pentobarbital - pharmacology ; Potassium - metabolism ; Sodium - metabolism ; Synapses - physiology</subject><ispartof>Stroke (1970), 1981-11, Vol.12 (6), p.726-730</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-44472b6b2759a616075c07be9b10538008df3564e8d67abe9269e786e412df3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7303061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Astrup, J</creatorcontrib><creatorcontrib>Sørensen, P M</creatorcontrib><creatorcontrib>Sørensen, H R</creatorcontrib><title>Oxygen and glucose consumption related to Na+-K+ transport in canine brain</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>This study examines the relation between Na+-K+ transport and metabolism in the canine brain. Cerebral oxygen and glucose consumption was measured by the sagittal sinus outflow technique. Synaptic transmission and related metabolism was blocked by pentobarbital 40 mg/kg (EEG flat). Lidocaine blocked an additional 15-20%, presumable by restricting Na+-K+ leak fluxes and reducing the demand for Na+-K+ transport. Ouabain blocked an additional 20-25% of metabolism. Ouabain also inhibited the Na+-K+ sensitive ATPase associated transport and caused a net efflux of K+ from the cellular compartment as evidenced by an increasing extracellular K+ concentration in the cortex. Accordingly, a total of 40% of metabolism in te EEG-arrested barbiturate inhibited brain could be related to Na+-K+ leak fluxes and associated transport. The remaining 60% are related to processes unidentified by this study. It is concluded that cerebral metabolism may be reduced below the hitherto described barbiturate minimum.</description><subject>Animals</subject><subject>Biological Transport</subject><subject>Brain - metabolism</subject><subject>Dogs</subject><subject>Electroencephalography</subject><subject>Glucose - metabolism</subject><subject>Lidocaine - pharmacology</subject><subject>Ouabain - pharmacology</subject><subject>Oxygen Consumption</subject><subject>Pentobarbital - pharmacology</subject><subject>Potassium - metabolism</subject><subject>Sodium - metabolism</subject><subject>Synapses - physiology</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LwzAYxoMoc07PnoScvIx2bz6atEcZfg8HbveQttmotElNUnD_vZUNTw-8z-99Dj-EbgmkhAiyAJKG6FNCU5FKKs7QlGSUJ1zQ_BxNAViRUF4Ul-gqhC8AoCzPJmgiGTAQZIre1j-HvbFY2xrv26FyweDK2TB0fWycxd60OpoaR4c_9Dx5n-PotQ298xE3FlfaNtbg0uvGXqOLnW6DuTnlDG2eHrfLl2S1fn5dPqySiucQE865pKUoqcwKLYgAmVUgS1OUBDKWA-T1jmWCm7wWUo93Kgojc2E4oWMzQ_fH1d6778GEqLomVKZttTVuCEoySTgT2QgujmDlXQje7FTvm077gyKg_twpIGqz_VSEKqFGd-PH3Wl6KDtT__MnWewX6PJo6w</recordid><startdate>198111</startdate><enddate>198111</enddate><creator>Astrup, J</creator><creator>Sørensen, P M</creator><creator>Sørensen, H R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198111</creationdate><title>Oxygen and glucose consumption related to Na+-K+ transport in canine brain</title><author>Astrup, J ; Sørensen, P M ; Sørensen, H R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-44472b6b2759a616075c07be9b10538008df3564e8d67abe9269e786e412df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Biological Transport</topic><topic>Brain - metabolism</topic><topic>Dogs</topic><topic>Electroencephalography</topic><topic>Glucose - metabolism</topic><topic>Lidocaine - pharmacology</topic><topic>Ouabain - pharmacology</topic><topic>Oxygen Consumption</topic><topic>Pentobarbital - pharmacology</topic><topic>Potassium - metabolism</topic><topic>Sodium - metabolism</topic><topic>Synapses - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Astrup, J</creatorcontrib><creatorcontrib>Sørensen, P M</creatorcontrib><creatorcontrib>Sørensen, H R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Astrup, J</au><au>Sørensen, P M</au><au>Sørensen, H R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen and glucose consumption related to Na+-K+ transport in canine brain</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>1981-11</date><risdate>1981</risdate><volume>12</volume><issue>6</issue><spage>726</spage><epage>730</epage><pages>726-730</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>This study examines the relation between Na+-K+ transport and metabolism in the canine brain. Cerebral oxygen and glucose consumption was measured by the sagittal sinus outflow technique. Synaptic transmission and related metabolism was blocked by pentobarbital 40 mg/kg (EEG flat). Lidocaine blocked an additional 15-20%, presumable by restricting Na+-K+ leak fluxes and reducing the demand for Na+-K+ transport. Ouabain blocked an additional 20-25% of metabolism. Ouabain also inhibited the Na+-K+ sensitive ATPase associated transport and caused a net efflux of K+ from the cellular compartment as evidenced by an increasing extracellular K+ concentration in the cortex. Accordingly, a total of 40% of metabolism in te EEG-arrested barbiturate inhibited brain could be related to Na+-K+ leak fluxes and associated transport. The remaining 60% are related to processes unidentified by this study. It is concluded that cerebral metabolism may be reduced below the hitherto described barbiturate minimum.</abstract><cop>United States</cop><pmid>7303061</pmid><doi>10.1161/01.str.12.6.726</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 1981-11, Vol.12 (6), p.726-730 |
| issn | 0039-2499 1524-4628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73714365 |
| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological Transport Brain - metabolism Dogs Electroencephalography Glucose - metabolism Lidocaine - pharmacology Ouabain - pharmacology Oxygen Consumption Pentobarbital - pharmacology Potassium - metabolism Sodium - metabolism Synapses - physiology |
| title | Oxygen and glucose consumption related to Na+-K+ transport in canine brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A32%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oxygen%20and%20glucose%20consumption%20related%20to%20Na+-K+%20transport%20in%20canine%20brain&rft.jtitle=Stroke%20(1970)&rft.au=Astrup,%20J&rft.date=1981-11&rft.volume=12&rft.issue=6&rft.spage=726&rft.epage=730&rft.pages=726-730&rft.issn=0039-2499&rft.eissn=1524-4628&rft_id=info:doi/10.1161/01.str.12.6.726&rft_dat=%3Cproquest_cross%3E73714365%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73714365&rft_id=info:pmid/7303061&rfr_iscdi=true |