In Vitro Cell Growth in Neonates With Down’s Syndrome and Transient Myeloproliferative Disorder
Bone marrow and peripheral blood cells from three newborns with Down’s syndrome and transient myeloproliferative disorders were cultured in vitro. In the methylcellulose semiliquid system, normal colony formation with maturation and differentiation into granulocytes and monocyte-macrophages were obs...
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| Veröffentlicht in: | Blood 1981-10, Vol.58 (4), p.675-677 |
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| creator | Denegri, J.F. Rogers, P.C.J. Chan, K.W. Sadoway, J. Thomas, J.W. |
| description | Bone marrow and peripheral blood cells from three newborns with Down’s syndrome and transient myeloproliferative disorders were cultured in vitro. In the methylcellulose semiliquid system, normal colony formation with maturation and differentiation into granulocytes and monocyte-macrophages were observed in all three patients. This is different from the growth pattern usually seen in acute nonlymphocytic leukemia. A maternal serum inhibitor of both normal allogeneic GM-CFU and blast cell growth was also demonstrated, but its role in pathogenesis is uncertain. Normal in vitro granulopoiesis may help to differentiate the transient myeloproliferative syndrome from congenital leukemia in newborns with Down’s syndrome. |
| doi_str_mv | 10.1182/blood.V58.4.675.675 |
| format | Article |
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In the methylcellulose semiliquid system, normal colony formation with maturation and differentiation into granulocytes and monocyte-macrophages were observed in all three patients. This is different from the growth pattern usually seen in acute nonlymphocytic leukemia. A maternal serum inhibitor of both normal allogeneic GM-CFU and blast cell growth was also demonstrated, but its role in pathogenesis is uncertain. Normal in vitro granulopoiesis may help to differentiate the transient myeloproliferative syndrome from congenital leukemia in newborns with Down’s syndrome.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V58.4.675.675</identifier><identifier>PMID: 6456025</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blood Cells - cytology ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Colony-Forming Units Assay ; Down Syndrome - blood ; Female ; Granulocytes - cytology ; Humans ; Infant, Newborn ; Maternal-Fetal Exchange ; Monocytes - cytology ; Myeloproliferative Disorders - blood ; Pregnancy</subject><ispartof>Blood, 1981-10, Vol.58 (4), p.675-677</ispartof><rights>1981 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3145-5f769b8ba33cf4216f808a5315975aabcb441212b82d087e3e3303f7010d92543</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6456025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Denegri, J.F.</creatorcontrib><creatorcontrib>Rogers, P.C.J.</creatorcontrib><creatorcontrib>Chan, K.W.</creatorcontrib><creatorcontrib>Sadoway, J.</creatorcontrib><creatorcontrib>Thomas, J.W.</creatorcontrib><title>In Vitro Cell Growth in Neonates With Down’s Syndrome and Transient Myeloproliferative Disorder</title><title>Blood</title><addtitle>Blood</addtitle><description>Bone marrow and peripheral blood cells from three newborns with Down’s syndrome and transient myeloproliferative disorders were cultured in vitro. In the methylcellulose semiliquid system, normal colony formation with maturation and differentiation into granulocytes and monocyte-macrophages were observed in all three patients. This is different from the growth pattern usually seen in acute nonlymphocytic leukemia. A maternal serum inhibitor of both normal allogeneic GM-CFU and blast cell growth was also demonstrated, but its role in pathogenesis is uncertain. Normal in vitro granulopoiesis may help to differentiate the transient myeloproliferative syndrome from congenital leukemia in newborns with Down’s syndrome.</description><subject>Blood Cells - cytology</subject><subject>Bone Marrow Cells</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Colony-Forming Units Assay</subject><subject>Down Syndrome - blood</subject><subject>Female</subject><subject>Granulocytes - cytology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal-Fetal Exchange</subject><subject>Monocytes - cytology</subject><subject>Myeloproliferative Disorders - blood</subject><subject>Pregnancy</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1uFDEQhS0ECpPACRCSV-x6KP-13QsWaAJJpEAWCWFpudvVwqjHDnZPotnlGrkeJ8HDjFiyKJVUr95T1UfIGwZLxgx_308p-eWtMku5bLXa1TOyYIqbBoDDc7IAgLaRnWYvyXEpPwGYFFwdkaNWqha4WhB3EeltmHOiK5wmepbTw_yDhki_YopuxkK_hzo4TQ_x9-NTodfb6HNaI3XR05vsYgkYZ_pli1O6y2kKI2Y3h3ukp6Gk7DG_Ii9GNxV8fegn5NvnTzer8-by6uxi9fGyGQSTqlGjbrve9E6IYZSctaMB45RgqtPKuX7opWSc8d5wD0ajQCFAjBoY-I4rKU7Iu31uPePXBsts16EM9SkXMW2K1UKD7kxXF8V-cciplIyjvcth7fLWMrA7sPYvWFvBWmkr1F1V19tD_KZfo__nOZCs-oe9jvXH-4DZlqGiGdCHjMNsfQr_zf8DzTiLBA</recordid><startdate>198110</startdate><enddate>198110</enddate><creator>Denegri, J.F.</creator><creator>Rogers, P.C.J.</creator><creator>Chan, K.W.</creator><creator>Sadoway, J.</creator><creator>Thomas, J.W.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198110</creationdate><title>In Vitro Cell Growth in Neonates With Down’s Syndrome and Transient Myeloproliferative Disorder</title><author>Denegri, J.F. ; Rogers, P.C.J. ; Chan, K.W. ; Sadoway, J. ; Thomas, J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3145-5f769b8ba33cf4216f808a5315975aabcb441212b82d087e3e3303f7010d92543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Blood Cells - cytology</topic><topic>Bone Marrow Cells</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>Colony-Forming Units Assay</topic><topic>Down Syndrome - blood</topic><topic>Female</topic><topic>Granulocytes - cytology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal-Fetal Exchange</topic><topic>Monocytes - cytology</topic><topic>Myeloproliferative Disorders - blood</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Denegri, J.F.</creatorcontrib><creatorcontrib>Rogers, P.C.J.</creatorcontrib><creatorcontrib>Chan, K.W.</creatorcontrib><creatorcontrib>Sadoway, J.</creatorcontrib><creatorcontrib>Thomas, J.W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Denegri, J.F.</au><au>Rogers, P.C.J.</au><au>Chan, K.W.</au><au>Sadoway, J.</au><au>Thomas, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Cell Growth in Neonates With Down’s Syndrome and Transient Myeloproliferative Disorder</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1981-10</date><risdate>1981</risdate><volume>58</volume><issue>4</issue><spage>675</spage><epage>677</epage><pages>675-677</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Bone marrow and peripheral blood cells from three newborns with Down’s syndrome and transient myeloproliferative disorders were cultured in vitro. 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| ispartof | Blood, 1981-10, Vol.58 (4), p.675-677 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Blood Cells - cytology Bone Marrow Cells Cell Differentiation Cells, Cultured Colony-Forming Units Assay Down Syndrome - blood Female Granulocytes - cytology Humans Infant, Newborn Maternal-Fetal Exchange Monocytes - cytology Myeloproliferative Disorders - blood Pregnancy |
| title | In Vitro Cell Growth in Neonates With Down’s Syndrome and Transient Myeloproliferative Disorder |
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