Stereo-dependent inhibition of human platelet function by the optical isomers of trimetoquinol

The stereoisomers of trimetoquinol [1-(3',4',5'-trimethoxybenzyl)-6–7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; TMQ] were shown to have potent and selective inhibitory effects on human platelet function in vitro. the R(+)-isomer was 12.1-, 12.3-, 39.2-, 82.9- and 36.0-fold more effect...

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Veröffentlicht in:	Biochemical pharmacology 1981-08, Vol.30 (16), p.2237-2241
Hauptverfasser:	Mayo, Joseph R., Navran, Stephen S., Huzoor-Akbar, Miller, Duane D., Feller, Dennis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Adenosine Diphosphate - antagonists & inhibitors Adenosine Diphosphate - pharmacology Blood Platelets - drug effects Humans In Vitro Techniques Isoquinolines - pharmacology Platelet Aggregation - drug effects Prostaglandin Endoperoxides, Synthetic - pharmacology Stereoisomerism Thromboxane A2 - metabolism Tretoquinol - pharmacology
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